Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells

Biochemical Pharmacology

Volumn 92, Issue 1, 2014, Pages 142-148

  Song, Na Young ^a   Na, Hye Kyung ^b   Baek, Jeong Heum ^c   Surh, Young Joon ^a,d  

^a Seoul National University   (South Korea)

^b Sungshin Women's University   (South Korea)

^c Gachon University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Colon cancer; Cyclooxygenase 2; Docosahexaenoic acid; Hyperinsulinemia; Obesity; SIRT1; Sterol regulatory element binding protein 1

Indexed keywords

CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; INSULIN; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR NRF2; SIRT1 PROTEIN, HUMAN; SREBF1 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CANCER PREVENTION; CELL MIGRATION; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERINSULINEMIA; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN ACETYLATION; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; CELL MOTION; COLON; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; CELL MOVEMENT; COLON; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACIDS; EPITHELIAL CELLS; HUMANS; INSULIN; MICE; MICE, OBESE; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UP-REGULATION;

EID: 84908177253     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.08.030     Document Type: Article

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