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Volumn 124, Issue 16, 2014, Pages 2487-2497

Bedside to bench in juvenile myelomonocytic leukemia: Insights into leukemogenesis from a rare pediatric leukemia

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; PROTEIN; PROTEIN NF 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 84908147740     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-03-300319     Document Type: Review
Times cited : (95)

References (116)
  • 1
    • 0030843626 scopus 로고    scopus 로고
    • Juvenile myelomonocytic leukemia
    • Aricò M, Biondi A, Pui CH. Juvenile myelomonocytic leukemia. Blood. 1997;90(2):479-488.
    • (1997) Blood , vol.90 , Issue.2 , pp. 479-488
    • Aricò, M.1    Biondi, A.2    Pui, C.H.3
  • 2
    • 0032851898 scopus 로고    scopus 로고
    • A population-based study of childhood myelodysplastic syndrome in British Columbia, Canada
    • Hasle H, Wadsworth LD, Massing BG, McBride M, Schultz KR. A population-based study of childhood myelodysplastic syndrome in British Columbia, Canada. Br J Haematol. 1999;106(4):1027-1032.
    • (1999) Br J Haematol , vol.106 , Issue.4 , pp. 1027-1032
    • Hasle, H.1    Wadsworth, L.D.2    Massing, B.G.3    McBride, M.4    Schultz, K.R.5
  • 3
    • 0038170405 scopus 로고    scopus 로고
    • Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia in the UK: A population-based study of incidence and survival
    • Passmore SJ, Chessells JM, Kempski H, Hann IM, Brownbill PA, Stiller CA. Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia in the UK: a population-based study of incidence and survival. Br J Haematol. 2003;121(5):758-767.
    • (2003) Br J Haematol , vol.121 , Issue.5 , pp. 758-767
    • Passmore, S.J.1    Chessells, J.M.2    Kempski, H.3    Hann, I.M.4    Brownbill, P.A.5    Stiller, C.A.6
  • 4
    • 19944428598 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): Results of the EWOG-MDS/EBMT trial
    • Locatelli F, Nöllke P, Zecca M, et al; European Working Group on Childhood MDS; European Blood and Marrow Transplantation Group. Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood. 2005;105(1):410-419.
    • (2005) Blood , vol.105 , Issue.1 , pp. 410-419
    • Locatelli, F.1    Nöllke, P.2    Zecca, M.3
  • 5
    • 0021233189 scopus 로고
    • Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors
    • Castro-Malaspina H, Schaison G, Passe S, et al. Subacute and chronic myelomonocytic leukemia in children (juvenile CML). Clinical and hematologic observations, and identification of prognostic factors. Cancer. 1984;54(4):675-686.
    • (1984) Cancer , vol.54 , Issue.4 , pp. 675-686
    • Castro-Malaspina, H.1    Schaison, G.2    Passe, S.3
  • 6
    • 34250017142 scopus 로고    scopus 로고
    • Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
    • Matsuda K, Shimada A, Yoshida N, et al. Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. Blood. 2007;109(12):5477-5480.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5477-5480
    • Matsuda, K.1    Shimada, A.2    Yoshida, N.3
  • 7
    • 38349111411 scopus 로고    scopus 로고
    • Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations
    • author reply 967-968
    • Flotho C, Kratz CP, Bergsträsser E, et al; European Working Group of Myelodysplastic Syndromes in Childhood. Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations. Blood. 2008;111(2):966-967, author reply 967-968.
    • (2008) Blood , vol.111 , Issue.2 , pp. 966-967
    • Flotho, C.1    Kratz, C.P.2    Bergsträsser, E.3
  • 8
    • 39749133834 scopus 로고    scopus 로고
    • Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: Molecular classification and treatment options
    • Niemeyer CM, Kratz CP. Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia: molecular classification and treatment options. Br J Haematol. 2008;140(6):610-624.
    • (2008) Br J Haematol , vol.140 , Issue.6 , pp. 610-624
    • Niemeyer, C.M.1    Kratz, C.P.2
  • 9
    • 79951979515 scopus 로고    scopus 로고
    • Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia
    • Loh ML. Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia. Br J Haematol. 2011;152(6):677-687.
    • (2011) Br J Haematol , vol.152 , Issue.6 , pp. 677-687
    • Loh, M.L.1
  • 10
    • 0037075886 scopus 로고    scopus 로고
    • GTPase activating proteins: Critical regulators of intracellular signaling
    • Donovan S, Shannon KM, Bollag G. GTPase activating proteins: critical regulators of intracellular signaling. Biochim Biophys Acta. 2002;1602(1):23-45.
    • (2002) Biochim Biophys Acta , vol.1602 , Issue.1 , pp. 23-45
    • Donovan, S.1    Shannon, K.M.2    Bollag, G.3
  • 11
    • 77951428717 scopus 로고    scopus 로고
    • Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit
    • Perugini M, Brown AL, Salerno DG, et al. Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit. Blood. 2010;115(16):3346-3353.
    • (2010) Blood , vol.115 , Issue.16 , pp. 3346-3353
    • Perugini, M.1    Brown, A.L.2    Salerno, D.G.3
  • 12
    • 0004586666 scopus 로고
    • Xantholeukemia in infants & Recklinghausen's neurofibromatosis
    • Royer P, Blondet C, Guihard J. [Xantholeukemia in infants & Recklinghausen's neurofibromatosis]. Sem Hop. 1958;34(24/5):1504-13/P.
    • (1958) Sem Hop , vol.34 , Issue.5-24 , pp. 1504-1513
    • Royer, P.1    Blondet, C.2    Guihard, J.3
  • 13
    • 0017880413 scopus 로고
    • Neurofibromatosis and childhood leukemia
    • Bader JL, Miller RW. Neurofibromatosis and childhood leukemia. J Pediatr. 1978;92(6):925-929.
    • (1978) J Pediatr , vol.92 , Issue.6 , pp. 925-929
    • Bader, J.L.1    Miller, R.W.2
  • 14
    • 0027974256 scopus 로고
    • Neurofibromatosis and childhood leukaemia/lymphoma: A population-based UKCCSG study
    • Stiller CA, Chessells JM, Fitchett M. Neurofibromatosis and childhood leukaemia/lymphoma: a population-based UKCCSG study. Br J Cancer. 1994;70(5):969-972.
    • (1994) Br J Cancer , vol.70 , Issue.5 , pp. 969-972
    • Stiller, C.A.1    Chessells, J.M.2    Fitchett, M.3
  • 15
    • 84856374290 scopus 로고    scopus 로고
    • Neoplasms associated with germline and somatic NF1 gene mutations
    • Patil S, Chamberlain RS. Neoplasms associated with germline and somatic NF1 gene mutations. Oncologist. 2012;17(1):101-116.
    • (2012) Oncologist , vol.17 , Issue.1 , pp. 101-116
    • Patil, S.1    Chamberlain, R.S.2
  • 16
    • 0025244911 scopus 로고
    • The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
    • Xu GF, Lin B, Tanaka K, et al. The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell. 1990;63(4):835-841.
    • (1990) Cell , vol.63 , Issue.4 , pp. 835-841
    • Xu, G.F.1    Lin, B.2    Tanaka, K.3
  • 17
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
    • Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature. 1992;356(6371):713-715.
    • (1992) Nature , vol.356 , Issue.6371 , pp. 713-715
    • Basu, T.N.1    Gutmann, D.H.2    Fletcher, J.A.3    Glover, T.W.4    Collins, F.S.5    Downward, J.6
  • 18
    • 0027979146 scopus 로고
    • Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders
    • Shannon KM, O'Connell P, Martin GA, et al. Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med. 1994;330(9):597-601.
    • (1994) N Engl J Med , vol.330 , Issue.9 , pp. 597-601
    • Shannon, K.M.1    O'Connell, P.2    Martin, G.A.3
  • 19
    • 0029908346 scopus 로고    scopus 로고
    • Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders
    • Miles DK, Freedman MH, Stephens K, et al. Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders. Blood. 1996;88(11):4314-4320.
    • (1996) Blood , vol.88 , Issue.11 , pp. 4314-4320
    • Miles, D.K.1    Freedman, M.H.2    Stephens, K.3
  • 20
    • 70349249988 scopus 로고    scopus 로고
    • Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
    • Loh ML, Sakai DS, Flotho C, et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood. 2009;114(9):1859-1863.
    • (2009) Blood , vol.114 , Issue.9 , pp. 1859-1863
    • Loh, M.L.1    Sakai, D.S.2    Flotho, C.3
  • 21
    • 84984935016 scopus 로고    scopus 로고
    • Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia
    • Niemeyer CM, Kang MW, Shin DH, et al. Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet. 2010;42(9):794-800.
    • (2010) Nat Genet , vol.42 , Issue.9 , pp. 794-800
    • Niemeyer, C.M.1    Kang, M.W.2    Shin, D.H.3
  • 22
    • 68949124841 scopus 로고    scopus 로고
    • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
    • Sanada M, Suzuki T, Shih L-Y, et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature. 2009;460(7257):904-908.
    • (2009) Nature , vol.460 , Issue.7257 , pp. 904-908
    • Sanada, M.1    Suzuki, T.2    Shih, L.-Y.3
  • 23
    • 9044251606 scopus 로고    scopus 로고
    • Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
    • Bollag G, Clapp DW, Shih S, et al. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet. 1996;12(2):144-148.
    • (1996) Nat Genet , vol.12 , Issue.2 , pp. 144-148
    • Bollag, G.1    Clapp, D.W.2    Shih, S.3
  • 24
    • 18344385476 scopus 로고    scopus 로고
    • Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
    • Tartaglia M, Mehler EL, Goldberg R, et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet. 2001;29(4):465-468.
    • (2001) Nat Genet , vol.29 , Issue.4 , pp. 465-468
    • Tartaglia, M.1    Mehler, E.L.2    Goldberg, R.3
  • 26
    • 0030712155 scopus 로고    scopus 로고
    • Occurrence of myeloproliferative disorder in patients with Noonan syndrome
    • Bader-Meunier B, Tchernia G, Miélot F, et al. Occurrence of myeloproliferative disorder in patients with Noonan syndrome. J Pediatr. 1997;130(6):885-889.
    • (1997) J Pediatr , vol.130 , Issue.6 , pp. 885-889
    • Bader-Meunier, B.1    Tchernia, G.2    Miélot, F.3
  • 27
    • 0030947237 scopus 로고    scopus 로고
    • Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders
    • Side L, Taylor B, Cayouette M, et al. Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med. 1997;336(24):1713-1720.
    • (1997) N Engl J Med , vol.336 , Issue.24 , pp. 1713-1720
    • Side, L.1    Taylor, B.2    Cayouette, M.3
  • 29
    • 0038278866 scopus 로고    scopus 로고
    • Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia
    • Tartaglia M, Niemeyer CM, Fragale A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet. 2003;34(2):148-150.
    • (2003) Nat Genet , vol.34 , Issue.2 , pp. 148-150
    • Tartaglia, M.1    Niemeyer, C.M.2    Fragale, A.3
  • 30
    • 12144286410 scopus 로고    scopus 로고
    • Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
    • Loh ML, Vattikuti S, Schubbert S, et al. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood. 2004;103(6):2325-2331.
    • (2004) Blood , vol.103 , Issue.6 , pp. 2325-2331
    • Loh, M.L.1    Vattikuti, S.2    Schubbert, S.3
  • 31
    • 0038771965 scopus 로고    scopus 로고
    • The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
    • Neel BG, Gu H, Pao L. The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci. 2003;28(6):284-293.
    • (2003) Trends Biochem Sci , vol.28 , Issue.6 , pp. 284-293
    • Neel, B.G.1    Gu, H.2    Pao, L.3
  • 32
    • 33846402073 scopus 로고    scopus 로고
    • The role of Shp2 (PTPN11) in cancer
    • Mohi MG, Neel BG. The role of Shp2 (PTPN11) in cancer. Curr Opin Genet Dev. 2007;17(1):23-30.
    • (2007) Curr Opin Genet Dev , vol.17 , Issue.1 , pp. 23-30
    • Mohi, M.G.1    Neel, B.G.2
  • 33
  • 34
    • 24744465207 scopus 로고    scopus 로고
    • Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes
    • Keilhack H, David FS, McGregor M, Cantley LC, Neel BG. Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J Biol Chem. 2005;280(35):30984-30993.
    • (2005) J Biol Chem , vol.280 , Issue.35 , pp. 30984-30993
    • Keilhack, H.1    David, F.S.2    McGregor, M.3    Cantley, L.C.4    Neel, B.G.5
  • 35
    • 0037064549 scopus 로고    scopus 로고
    • Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
    • Qu C-K. Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response. Biochim Biophys Acta. 2002;1592(3):297-301.
    • (2002) Biochim Biophys Acta , vol.1592 , Issue.3 , pp. 297-301
    • Qu, C.-K.1
  • 36
    • 1842525884 scopus 로고    scopus 로고
    • SHP-2 regulates the phosphatidylinositide 39-kinase/Akt pathway and suppresses caspase 3′-mediated apoptosis
    • Ivins Zito C, Kontaridis MI, Fornaro M, Feng G-S, Bennett AM. SHP-2 regulates the phosphatidylinositide 39-kinase/Akt pathway and suppresses caspase 3′-mediated apoptosis. J Cell Physiol. 2004;199(2):227-236.
    • (2004) J Cell Physiol , vol.199 , Issue.2 , pp. 227-236
    • Ivins Zito, C.1    Kontaridis, M.I.2    Fornaro, M.3    Feng, G.-S.4    Bennett, A.M.5
  • 37
    • 0032932203 scopus 로고    scopus 로고
    • Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    • Oh ES, Gu H, Saxton TM, et al. Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol. 1999;19(4):3205-3215.
    • (1999) Mol Cell Biol , vol.19 , Issue.4 , pp. 3205-3215
    • Oh, E.S.1    Gu, H.2    Saxton, T.M.3
  • 38
    • 24744455046 scopus 로고    scopus 로고
    • The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
    • Kratz CP, Niemeyer CM, Castleberry RP, et al. The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. Blood. 2005;106(6):2183-2185.
    • (2005) Blood , vol.106 , Issue.6 , pp. 2183-2185
    • Kratz, C.P.1    Niemeyer, C.M.2    Castleberry, R.P.3
  • 39
    • 22044452124 scopus 로고    scopus 로고
    • Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells
    • Schubbert S, Lieuw K, Rowe SL, et al. Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood. 2005;106(1):311-317.
    • (2005) Blood , vol.106 , Issue.1 , pp. 311-317
    • Schubbert, S.1    Lieuw, K.2    Rowe, S.L.3
  • 40
    • 13844265841 scopus 로고    scopus 로고
    • Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations
    • Mohi MG, Williams IR, Dearolf CR, et al. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell. 2005;7(2):179-191.
    • (2005) Cancer Cell , vol.7 , Issue.2 , pp. 179-191
    • Mohi, M.G.1    Williams, I.R.2    Dearolf, C.R.3
  • 41
    • 84864019022 scopus 로고    scopus 로고
    • A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation
    • Huang H, Woo AJ, Waldon Z, et al. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 2012;26(14):1587-1601.
    • (2012) Genes Dev , vol.26 , Issue.14 , pp. 1587-1601
    • Huang, H.1    Woo, A.J.2    Waldon, Z.3
  • 42
    • 84908141853 scopus 로고    scopus 로고
    • Potential Role of RUNX1 in the Pathogenesis of Juvenile Myelomonocytic Leukemia (JMML)
    • Huang H, Bauer DE, Loh ML, et al. Potential Role of RUNX1 in the Pathogenesis of Juvenile Myelomonocytic Leukemia (JMML). Blood. 2013;122(21):45.
    • (2013) Blood , vol.122 , Issue.21 , pp. 45
    • Huang, H.1    Bauer, D.E.2    Loh, M.L.3
  • 43
    • 0028125213 scopus 로고
    • Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras
    • Kalra R, Paderanga DC, Olson K, Shannon KM. Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras. Blood. 1994;84(10):3435-3439.
    • (1994) Blood , vol.84 , Issue.10 , pp. 3435-3439
    • Kalra, R.1    Paderanga, D.C.2    Olson, K.3    Shannon, K.M.4
  • 44
    • 0028344097 scopus 로고
    • Mutations of the N-ras gene in juvenile chronic myelogenous leukemia
    • Miyauchi J, Asada M, Sasaki M, Tsunematsu Y, Kojima S, Mizutani S. Mutations of the N-ras gene in juvenile chronic myelogenous leukemia. Blood. 1994;83(8):2248-2254.
    • (1994) Blood , vol.83 , Issue.8 , pp. 2248-2254
    • Miyauchi, J.1    Asada, M.2    Sasaki, M.3    Tsunematsu, Y.4    Kojima, S.5    Mizutani, S.6
  • 45
    • 0345743699 scopus 로고    scopus 로고
    • Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder
    • Braun BS, Tuveson DA, Kong N, et al. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc Natl Acad Sci USA. 2004;101(2):597-602.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.2 , pp. 597-602
    • Braun, B.S.1    Tuveson, D.A.2    Kong, N.3
  • 46
    • 63849313577 scopus 로고    scopus 로고
    • Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis
    • Chan G, Kalaitzidis D, Usenko T, et al. Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis. Blood. 2009;113(18):4414-4424.
    • (2009) Blood , vol.113 , Issue.18 , pp. 4414-4424
    • Chan, G.1    Kalaitzidis, D.2    Usenko, T.3
  • 47
    • 84865155361 scopus 로고    scopus 로고
    • Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
    • Doisaki S, Muramatsu H, Shimada A, et al. Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia. Blood. 2012;120(7):1485-1488.
    • (2012) Blood , vol.120 , Issue.7 , pp. 1485-1488
    • Doisaki, S.1    Muramatsu, H.2    Shimada, A.3
  • 48
    • 84880573567 scopus 로고    scopus 로고
    • Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS due to acquired uniparental disomy
    • Kato M, Yasui N, Seki M, et al. Aggressive transformation of juvenile myelomonocytic leukemia associated with duplication of oncogenic KRAS due to acquired uniparental disomy. J Pediatr. 2013;162(6):1285-1288.
    • (2013) J Pediatr , vol.162 , Issue.6 , pp. 1285-1288
    • Kato, M.1    Yasui, N.2    Seki, M.3
  • 49
    • 79953124749 scopus 로고    scopus 로고
    • Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation
    • Takagi M, Shinoda K, Piao J, et al. Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation. Blood. 2011;117(10):2887-2890.
    • (2011) Blood , vol.117 , Issue.10 , pp. 2887-2890
    • Takagi, M.1    Shinoda, K.2    Piao, J.3
  • 50
    • 79953113625 scopus 로고    scopus 로고
    • Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
    • Niemela JE, Lu L, Fleisher TA, et al. Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. Blood. 2011;117(10):2883-2886.
    • (2011) Blood , vol.117 , Issue.10 , pp. 2883-2886
    • Niemela, J.E.1    Lu, L.2    Fleisher, T.A.3
  • 51
    • 34547461299 scopus 로고    scopus 로고
    • NRAS mutation causes a human autoimmune lymphoproliferative syndrome
    • Oliveira JB, Bidère N, Niemela JE, et al. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci USA. 2007;104(21):8953-8958.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.21 , pp. 8953-8958
    • Oliveira, J.B.1    Bidère, N.2    Niemela, J.E.3
  • 52
    • 77950382457 scopus 로고    scopus 로고
    • Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia
    • Muramatsu H, Makishima H, Jankowska AM, et al. Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia. Blood. 2010;115(10):1969-1975.
    • (2010) Blood , vol.115 , Issue.10 , pp. 1969-1975
    • Muramatsu, H.1    Makishima, H.2    Jankowska, A.M.3
  • 53
    • 57749114621 scopus 로고    scopus 로고
    • 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
    • Dunbar AJ, Gondek LP, O'Keefe CL, et al. 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res. 2008;68(24):10349-10357.
    • (2008) Cancer Res , vol.68 , Issue.24 , pp. 10349-10357
    • Dunbar, A.J.1    Gondek, L.P.2    O'Keefe, C.L.3
  • 54
    • 67650401377 scopus 로고    scopus 로고
    • Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
    • Grand FH, Hidalgo-Curtis CE, Ernst T, et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood. 2009;113(24):6182-6192.
    • (2009) Blood , vol.113 , Issue.24 , pp. 6182-6192
    • Grand, F.H.1    Hidalgo-Curtis, C.E.2    Ernst, T.3
  • 55
    • 74949108515 scopus 로고    scopus 로고
    • Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies
    • Makishima H, Cazzolli H, Szpurka H, et al. Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies. J Clin Oncol. 2009;27(36):6109-6116.
    • (2009) J Clin Oncol , vol.27 , Issue.36 , pp. 6109-6116
    • Makishima, H.1    Cazzolli, H.2    Szpurka, H.3
  • 56
    • 28844490931 scopus 로고    scopus 로고
    • The Cbl interactome and its functions
    • Schmidt MHH, Dikic I. The Cbl interactome and its functions. Nat Rev Mol Cell Biol. 2005;6(12):907-918.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.12 , pp. 907-918
    • Schmidt, M.H.H.1    Dikic, I.2
  • 57
    • 84877630975 scopus 로고    scopus 로고
    • Oncogenic signaling by leukemia-associated mutant Cbl proteins
    • Nadeau S, An W, Palermo N, et al. Oncogenic signaling by leukemia-associated mutant Cbl proteins. Biochem Anal Biochem. 2012;Suppl 6(1):7921.
    • (2012) Biochem Anal Biochem , Issue.1 , pp. 7921
    • Nadeau, S.1    An, W.2    Palermo, N.3
  • 58
    • 84880062396 scopus 로고    scopus 로고
    • CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN
    • Javadi M, Richmond TD, Huang K, Barber DL. CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN. J Biol Chem. 2013;288(27):19459-19470.
    • (2013) J Biol Chem , vol.288 , Issue.27 , pp. 19459-19470
    • Javadi, M.1    Richmond, T.D.2    Huang, K.3    Barber, D.L.4
  • 59
    • 77957809576 scopus 로고    scopus 로고
    • Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukaemia
    • Pérez B, Mechinaud F, Galambrun C, et al. Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukaemia. J Med Genet. 2010;47(10):686-691.
    • (2010) J Med Genet , vol.47 , Issue.10 , pp. 686-691
    • Pérez, B.1    Mechinaud, F.2    Galambrun, C.3
  • 60
    • 84890439281 scopus 로고    scopus 로고
    • In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia
    • Strullu M, Caye A, Cassinat B, et al. In hematopoietic cells with a germline mutation of CBL, loss of heterozygosity is not a signature of juvenile myelo-monocytic leukemia. Leukemia. 2013;27(12):2404-2407.
    • (2013) Leukemia , vol.27 , Issue.12 , pp. 2404-2407
    • Strullu, M.1    Caye, A.2    Cassinat, B.3
  • 61
    • 84908135678 scopus 로고    scopus 로고
    • Clinical and genetic characterization of patients with C-CBL mutated juvenile myelomonocytic leukemia by whole-exome/deep sequencing
    • abstract
    • Muramatsu H, Sakaguchi H, Wang X, et al. Clinical and genetic characterization of patients with C-CBL mutated juvenile myelomonocytic leukemia by whole-exome/deep sequencing [abstract]. Blood. 2013;122(21). Abstract 1565.
    • (2013) Blood , vol.122 , Issue.21
    • Muramatsu, H.1    Sakaguchi, H.2    Wang, X.3
  • 62
    • 78349249756 scopus 로고    scopus 로고
    • Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia
    • Pérez B, Kosmider O, Cassinat B, et al. Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia. Br J Haematol. 2010;151(5):460-468.
    • (2010) Br J Haematol , vol.151 , Issue.5 , pp. 460-468
    • Pérez, B.1    Kosmider, O.2    Cassinat, B.3
  • 63
    • 77953485589 scopus 로고    scopus 로고
    • Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations
    • Sugimoto Y, Muramatsu H, Makishima H, et al. Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations. Br J Haematol. 2010;150(1):83-87.
    • (2010) Br J Haematol , vol.150 , Issue.1 , pp. 83-87
    • Sugimoto, Y.1    Muramatsu, H.2    Makishima, H.3
  • 64
  • 65
    • 84858672060 scopus 로고    scopus 로고
    • Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML
    • Hirabayashi S, Flotho C, Moetter J, et al; European Working Group of MDS in Childhood. Spliceosomal gene aberrations are rare, coexist with oncogenic mutations, and are unlikely to exert a driver effect in childhood MDS and JMML. Blood. 2012;119(11):e96-e99.
    • (2012) Blood , vol.119 , Issue.11 , pp. e96-e99
    • Hirabayashi, S.1    Flotho, C.2    Moetter, J.3
  • 66
    • 84881020319 scopus 로고    scopus 로고
    • Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
    • Sakaguchi H, Okuno Y, Muramatsu H, et al. Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet. 2013;45(8):937-941.
    • (2013) Nat Genet , vol.45 , Issue.8 , pp. 937-941
    • Sakaguchi, H.1    Okuno, Y.2    Muramatsu, H.3
  • 67
    • 84871988651 scopus 로고    scopus 로고
    • Recurrent SETBP1 mutations in atypical chronic myeloid leukemia
    • Piazza R, Valletta S, Winkelmann N, et al. Recurrent SETBP1 mutations in atypical chronic myeloid leukemia. Nat Genet. 2013;45(1):18-24.
    • (2013) Nat Genet , vol.45 , Issue.1 , pp. 18-24
    • Piazza, R.1    Valletta, S.2    Winkelmann, N.3
  • 68
    • 77952888699 scopus 로고    scopus 로고
    • De novo mutations of SETBP1 cause Schinzel-Giedion syndrome
    • Hoischen A, van Bon BWM, Gilissen C, et al. De novo mutations of SETBP1 cause Schinzel-Giedion syndrome. Nat Genet. 2010;42(6):483-485.
    • (2010) Nat Genet , vol.42 , Issue.6 , pp. 483-485
    • Hoischen, A.1    Van Bon, B.W.M.2    Gilissen, C.3
  • 69
    • 84862734488 scopus 로고    scopus 로고
    • Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
    • Oakley K, Han Y, Vishwakarma BA, et al. Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10. Blood. 2012;119(25):6099-6108.
    • (2012) Blood , vol.119 , Issue.25 , pp. 6099-6108
    • Oakley, K.1    Han, Y.2    Vishwakarma, B.A.3
  • 71
    • 84884982828 scopus 로고    scopus 로고
    • Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression
    • Fernandez-Mercado M, Pellagatti A, Di Genua C, et al. Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression. Br J Haematol. 2013;163(2):235-239.
    • (2013) Br J Haematol , vol.163 , Issue.2 , pp. 235-239
    • Fernandez-Mercado, M.1    Pellagatti, A.2    Di Genua, C.3
  • 72
    • 33645960451 scopus 로고    scopus 로고
    • Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance
    • Calin GA, Croce CM. Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. Semin Oncol. 2006;33(2):167-173.
    • (2006) Semin Oncol , vol.33 , Issue.2 , pp. 167-173
    • Calin, G.A.1    Croce, C.M.2
  • 73
    • 54249117763 scopus 로고    scopus 로고
    • A SNP in a let-7 microRNA complementary site in the KRAS 3′ untranslated region increases non-small cell lung cancer risk
    • Chin LJ, Ratner E, Leng S, et al. A SNP in a let-7 microRNA complementary site in the KRAS 3′ untranslated region increases non-small cell lung cancer risk. Cancer Res. 2008;68(20):8535-8540.
    • (2008) Cancer Res , vol.68 , Issue.20 , pp. 8535-8540
    • Chin, L.J.1    Ratner, E.2    Leng, S.3
  • 74
    • 77956802199 scopus 로고    scopus 로고
    • Mutations in the let-7 binding site - A mechanism of RAS activation in juvenile myelomonocytic leukemia?
    • Steinemann D, Tauscher M, Praulich I, Niemeyer CM, Flotho C, Schlegelberger B. Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia? Haematologica. 2010;95(9):1616.
    • (2010) Haematologica , vol.95 , Issue.9 , pp. 1616
    • Steinemann, D.1    Tauscher, M.2    Praulich, I.3    Niemeyer, C.M.4    Flotho, C.5    Schlegelberger, B.6
  • 75
    • 84880264101 scopus 로고    scopus 로고
    • Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia
    • Liu YL, Lensing SY, Yan Y, Cooper TM, Loh ML, Emanuel PD. Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia. Leukemia. 2013;27(7):1585-1588.
    • (2013) Leukemia , vol.27 , Issue.7 , pp. 1585-1588
    • Liu, Y.L.1    Lensing, S.Y.2    Yan, Y.3    Cooper, T.M.4    Loh, M.L.5    Emanuel, P.D.6
  • 76
    • 78649910285 scopus 로고    scopus 로고
    • MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration
    • Sarver AL, Li L, Subramanian S. MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration. Cancer Res. 2010;70(23):9570-9580.
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9570-9580
    • Sarver, A.L.1    Li, L.2    Subramanian, S.3
  • 77
    • 61949288688 scopus 로고    scopus 로고
    • Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia
    • Yoshida N, Yagasaki H, Xu Y, et al. Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. Pediatr Res. 2009;65(3):334-340.
    • (2009) Pediatr Res , vol.65 , Issue.3 , pp. 334-340
    • Yoshida, N.1    Yagasaki, H.2    Xu, Y.3
  • 78
    • 84860825966 scopus 로고    scopus 로고
    • Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia
    • Park H-D, Lee SH, Sung KW, et al. Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia. Ann Hematol. 2012;91(4):511-517.
    • (2012) Ann Hematol , vol.91 , Issue.4 , pp. 511-517
    • Park, H.-D.1    Lee, S.H.2    Sung, K.W.3
  • 79
    • 84887600939 scopus 로고    scopus 로고
    • Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: A EUROCORD, EBMT, EWOG-MDS, CIBMTR study
    • Locatelli F, Crotta A, Ruggeri A, et al. Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study. Blood. 2013;122(12):2135-2141.
    • (2013) Blood , vol.122 , Issue.12 , pp. 2135-2141
    • Locatelli, F.1    Crotta, A.2    Ruggeri, A.3
  • 80
    • 77951644021 scopus 로고    scopus 로고
    • Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia
    • Bresolin S, Zecca M, Flotho C, et al. Gene expression-based classification as an independent predictor of clinical outcome in juvenile myelomonocytic leukemia. J Clin Oncol. 2010;28(11):1919-1927.
    • (2010) J Clin Oncol , vol.28 , Issue.11 , pp. 1919-1927
    • Bresolin, S.1    Zecca, M.2    Flotho, C.3
  • 81
    • 79955968990 scopus 로고    scopus 로고
    • Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome
    • Olk-Batz C, Poetsch AR, Nöllke P, et al; European Working Group of Myelodysplastic Syndromes in Childhood (EWOG-MDS). Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome. Blood. 2011;117(18):4871-4880.
    • (2011) Blood , vol.117 , Issue.18 , pp. 4871-4880
    • Olk-Batz, C.1    Poetsch, A.R.2    Nöllke, P.3
  • 82
    • 2542457470 scopus 로고    scopus 로고
    • Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder
    • Le DT, Kong N, Zhu Y, et al. Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder. Blood. 2004;103(11):4243-4250.
    • (2004) Blood , vol.103 , Issue.11 , pp. 4243-4250
    • Kong N, L.D.T.1    Zhu, Y.2
  • 83
    • 84873844410 scopus 로고    scopus 로고
    • Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice
    • Chang T, Krisman K, Theobald EH, et al. Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest. 2013;123(1):335-339.
    • (2013) J Clin Invest , vol.123 , Issue.1 , pp. 335-339
    • Chang, T.1    Krisman, K.2    Theobald, E.H.3
  • 84
    • 79953252390 scopus 로고    scopus 로고
    • A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice
    • Lyubynska N, Gorman MF, Lauchle JO, et al. A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice. Sci Transl Med. 2011;3(76):76ra27.
    • (2011) Sci Transl Med , vol.3 , Issue.76 , pp. 76ra27
    • Lyubynska, N.1    Gorman, M.F.2    Lauchle, J.O.3
  • 85
    • 79951472496 scopus 로고    scopus 로고
    • Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus
    • Li Q, Haigis KM, McDaniel A, et al. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011;117(6):2022-2032.
    • (2011) Blood , vol.117 , Issue.6 , pp. 2022-2032
    • Li, Q.1    Haigis, K.M.2    McDaniel, A.3
  • 86
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • Wilson A, Laurenti E, Oser G, et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell. 2008;135(6):1118-1129.
    • (2008) Cell , vol.135 , Issue.6 , pp. 1118-1129
    • Wilson, A.1    Laurenti, E.2    Oser, G.3
  • 87
    • 65949123563 scopus 로고    scopus 로고
    • Oncogenic Kras initiates leukemia in hematopoietic stem cells
    • Sabnis AJ, Cheung LS, Dail M, et al. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009;7(3):e59.
    • (2009) PLoS Biol , vol.7 , Issue.3 , pp. e59
    • Sabnis, A.J.1    Cheung, L.S.2    Dail, M.3
  • 88
    • 84889598519 scopus 로고    scopus 로고
    • Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness
    • Li Q, Bohin N, Wen T, et al. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature. 2013;504(7478):143-147.
    • (2013) Nature , vol.504 , Issue.7478 , pp. 143-147
    • Li, Q.1    Bohin, N.2    Wen, T.3
  • 89
    • 70449364013 scopus 로고    scopus 로고
    • Germ-line mutation of the NRAS gene may be responsible for the development of juvenile myelomonocytic leukaemia
    • De Filippi P, Zecca M, Lisini D, et al. Germ-line mutation of the NRAS gene may be responsible for the development of juvenile myelomonocytic leukaemia. Br J Haematol. 2009;147(5):706-709.
    • (2009) Br J Haematol , vol.147 , Issue.5 , pp. 706-709
    • De Filippi, P.1    Zecca, M.2    Lisini, D.3
  • 90
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, et al. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008;14(4):335-343.
    • (2008) Cancer Cell , vol.14 , Issue.4 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3
  • 91
    • 4043056497 scopus 로고    scopus 로고
    • Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
    • Araki T, Mohi MG, Ismat FA, et al. Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. Nat Med. 2004;10(8):849-857.
    • (2004) Nat Med , vol.10 , Issue.8 , pp. 849-857
    • Araki, T.1    Mohi, M.G.2    Ismat, F.A.3
  • 92
    • 77958001789 scopus 로고    scopus 로고
    • Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells
    • 14
    • Naramura M, Nandwani N, Gu H, Band V, Band H. Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells. Proc Natl Acad Sci U S A. 2010 14;107(37):16274-16279.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.37 , pp. 16274-16279
    • Naramura, M.1    Nandwani, N.2    Gu, H.3    Band, V.4    Band, H.5
  • 93
    • 84863505092 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples
    • Kumano K, Arai S, Hosoi M, et al. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood. 2012;119(26):6234-6242.
    • (2012) Blood , vol.119 , Issue.26 , pp. 6234-6242
    • Kumano, K.1    Arai, S.2    Hosoi, M.3
  • 94
    • 84881286879 scopus 로고    scopus 로고
    • Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia
    • Gandre-Babbe S, Paluru P, Aribeana C, et al. Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. Blood. 2013;121(24):4925-4929.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4925-4929
    • Gandre-Babbe, S.1    Paluru, P.2    Aribeana, C.3
  • 95
    • 0026063878 scopus 로고
    • Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors
    • Emanuel PD, Bates LJ, Castleberry RP, Gualtieri RJ, Zuckerman KS. Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood. 1991;77(5):925-929.
    • (1991) Blood , vol.77 , Issue.5 , pp. 925-929
    • Emanuel, P.D.1    Bates, L.J.2    Castleberry, R.P.3    Gualtieri, R.J.4    Zuckerman, K.S.5
  • 96
    • 58549090093 scopus 로고    scopus 로고
    • Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium
    • Chan RJ, Cooper T, Kratz CP, Weiss B, Loh ML. Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium. Leuk Res. 2009;33(3):355-362.
    • (2009) Leuk Res , vol.33 , Issue.3 , pp. 355-362
    • Chan, R.J.1    Cooper, T.2    Kratz, C.P.3    Weiss, B.4    Loh, M.L.5
  • 97
    • 38949143672 scopus 로고    scopus 로고
    • Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia
    • Archambeault S, Flores NJ, Yoshimi A, et al. Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia. Blood. 2008;111(3):1124-1127.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1124-1127
    • Archambeault, S.1    Flores, N.J.2    Yoshimi, A.3
  • 98
    • 84888407334 scopus 로고    scopus 로고
    • Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia
    • Hasegawa D, Bugarin C, Giordan M, et al. Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia. Blood Cancer J. 2013;3(11):e160.
    • (2013) Blood Cancer J , vol.3 , Issue.11 , pp. e160
    • Hasegawa, D.1    Bugarin, C.2    Giordan, M.3
  • 99
    • 0028138595 scopus 로고
    • A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia
    • Castleberry RP, Emanuel PD, Zuckerman KS, et al. A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia. N Engl J Med. 1994;331(25):1680-1684.
    • (1994) N Engl J Med , vol.331 , Issue.25 , pp. 1680-1684
    • Castleberry, R.P.1    Emanuel, P.D.2    Zuckerman, K.S.3
  • 100
    • 85014195924 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group
    • Manabe A, Okamura J, Yumura-Yagi K, et al; MDS Committee of the Japanese Society of Pediatric Hematology. Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the International JMML Working Group. Leukemia. 2002;16(4):645-649.
    • (2002) Leukemia , vol.16 , Issue.4 , pp. 645-649
    • Manabe, A.1    Okamura, J.2    Yumura-Yagi, K.3
  • 101
    • 84876704034 scopus 로고    scopus 로고
    • Increased risk of gastrointestinal acute GVHD following the addition of melphalan to busulfan/ cyclophosphamide conditioning
    • Ma˚rtensson T, Priftakis P, Casswall T, et al. Increased risk of gastrointestinal acute GVHD following the addition of melphalan to busulfan/ cyclophosphamide conditioning. Pediatr Transplant. 2013;17(3):285-293.
    • (2013) Pediatr Transplant , vol.17 , Issue.3 , pp. 285-293
    • Ma˚rtensson, T.1    Priftakis, P.2    Casswall, T.3
  • 102
    • 84896853949 scopus 로고    scopus 로고
    • Fludarabine and exposure-targeted busulfan compares favorably with busulfan/cyclophosphamide-based regimens in pediatric hematopoietic cell transplantation: Maintaining efficacy with less toxicity
    • Bartelink IH, van Reij EML, Gerhardt CE, et al. Fludarabine and exposure-targeted busulfan compares favorably with busulfan/cyclophosphamide-based regimens in pediatric hematopoietic cell transplantation: maintaining efficacy with less toxicity. Biol Blood Marrow Transplant. 2014;20(3):345-353.
    • (2014) Biol Blood Marrow Transplant , vol.20 , Issue.3 , pp. 345-353
    • Bartelink, I.H.1    Van Reij, E.M.L.2    Gerhardt, C.E.3
  • 103
    • 84870232539 scopus 로고    scopus 로고
    • Outcomes of immunological interventions for mixed chimerism following allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia
    • Inagaki J, Fukano R, Nishikawa T, et al. Outcomes of immunological interventions for mixed chimerism following allogeneic stem cell transplantation in children with juvenile myelomonocytic leukemia. Pediatr Blood Cancer. 2013;60(1):116-120.
    • (2013) Pediatr Blood Cancer , vol.60 , Issue.1 , pp. 116-120
    • Inagaki, J.1    Fukano, R.2    Nishikawa, T.3
  • 104
    • 63949085142 scopus 로고    scopus 로고
    • Feasibility study of preemptive withdrawal of immunosuppression based on chimerism testing in children undergoing myeloablative allogeneic transplantation for hematologic malignancies
    • Horn B, Soni S, Khan S, et al. Feasibility study of preemptive withdrawal of immunosuppression based on chimerism testing in children undergoing myeloablative allogeneic transplantation for hematologic malignancies. Bone Marrow Transplant. 2009;43(6):469-476.
    • (2009) Bone Marrow Transplant , vol.43 , Issue.6 , pp. 469-476
    • Horn, B.1    Soni, S.2    Khan, S.3
  • 105
    • 20044376886 scopus 로고    scopus 로고
    • Chimaerism analyses and subsequent immunological intervention after stem cell transplantation in patients with juvenile myelomonocytic leukaemia
    • Yoshimi A, Niemeyer CM, Bohmer V, et al. Chimaerism analyses and subsequent immunological intervention after stem cell transplantation in patients with juvenile myelomonocytic leukaemia. Br J Haematol. 2005;129(4):542-549.
    • (2005) Br J Haematol , vol.129 , Issue.4 , pp. 542-549
    • Yoshimi, A.1    Niemeyer, C.M.2    Bohmer, V.3
  • 106
    • 33847184613 scopus 로고    scopus 로고
    • Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia
    • Yoshimi A, Mohamed M, Bierings M, et al. Second allogeneic hematopoietic stem cell transplantation (HSCT) results in outcome similar to that of first HSCT for patients with juvenile myelomonocytic leukemia. Leukemia. 2007;21(3):556-560.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 556-560
    • Yoshimi, A.1    Mohamed, M.2    Bierings, M.3
  • 107
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 2003;3(1):11-22.
    • (2003) Nat Rev Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 108
    • 0033214846 scopus 로고    scopus 로고
    • In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
    • Mahgoub N, Taylor BR, Gratiot M, et al. In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. Blood. 1999;94(7):2469-2476.
    • (1999) Blood , vol.94 , Issue.7 , pp. 2469-2476
    • Mahgoub, N.1    Taylor, B.R.2    Gratiot, M.3
  • 109
    • 84908128334 scopus 로고    scopus 로고
    • Window study of the farnesyltransferase inhibitor R115777 (Zarnestra(R)) in untreated juvenile myelomonocytic leukemia (JMML): A Children's Oncology Group Study
    • abstract
    • Castleberry RP, Loh ML, Jayaprakash N, et al. Window study of the farnesyltransferase inhibitor R115777 (Zarnestra(R)) in untreated juvenile myelomonocytic leukemia (JMML): a Children's Oncology Group Study [abstract]. Blood. 2005;106. Abstract 2587.
    • (2005) Blood , vol.106
    • Castleberry, R.P.1    Loh, M.L.2    Jayaprakash, N.3
  • 110
    • 84885224619 scopus 로고    scopus 로고
    • Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation
    • Xu J, Haigis KM, Firestone AJ, et al. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov. 2013;3(9):993-1001.
    • (2013) Cancer Discov , vol.3 , Issue.9 , pp. 993-1001
    • Xu, J.1    Haigis, K.M.2    Firestone, A.J.3
  • 111
    • 84863967243 scopus 로고    scopus 로고
    • Genetic disruption of the PI3K regulatory subunits, p85a, p55a, and p50a, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF
    • Goodwin CB, Yang Z, Yin F, Yu M, Chan RJ. Genetic disruption of the PI3K regulatory subunits, p85a, p55a, and p50a, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF. Haematologica. 2012;97(7):1042-1047.
    • (2012) Haematologica , vol.97 , Issue.7 , pp. 1042-1047
    • Goodwin, C.B.1    Yang, Z.2    Yin, F.3    Yu, M.4    Chan, R.J.5
  • 112
    • 84876931998 scopus 로고    scopus 로고
    • Inhibition of SRC corrects GM-CSF hypersensitivity that underlies juvenile myelomonocytic leukemia
    • Bunda S, Kang MW, Sybingco SS, et al. Inhibition of SRC corrects GM-CSF hypersensitivity that underlies juvenile myelomonocytic leukemia. Cancer Res. 2013;73(8):2540-2550.
    • (2013) Cancer Res , vol.73 , Issue.8 , pp. 2540-2550
    • Bunda, S.1    Kang, M.W.2    Sybingco, S.S.3
  • 113
    • 85027914373 scopus 로고    scopus 로고
    • Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway
    • Bunda S, Qin K, Kommaraju K, Heir P, Ohh M. Juvenile myelomonocytic leukaemia-associated mutation in Cbl promotes resistance to apoptosis via the Lyn-PI3K/AKT pathway. Oncogene. 2014;2014:1-9.
    • (2014) Oncogene , vol.2014 , pp. 1-9
    • Bunda, S.1    Qin, K.2    Kommaraju, K.3    Heir, P.4    Ohh, M.5
  • 114
    • 64849114262 scopus 로고    scopus 로고
    • Aberrant GM-CSF signal transduction pathway in juvenile myelomonocytic leukemia assayed by flow cytometric intracellular STAT5 phosphorylation measurement
    • Gaipa G, Bugarin C, Longoni D, et al. Aberrant GM-CSF signal transduction pathway in juvenile myelomonocytic leukemia assayed by flow cytometric intracellular STAT5 phosphorylation measurement. Leukemia. 2009;23(4):791-793.
    • (2009) Leukemia , vol.23 , Issue.4 , pp. 791-793
    • Gaipa, G.1    Bugarin, C.2    Longoni, D.3
  • 115
    • 84902135612 scopus 로고    scopus 로고
    • Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm
    • Kong G, Wunderlich M, Yang D, et al. Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. J Clin Invest. 2014;124(6):2762-2773.
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2762-2773
    • Kong, G.1    Wunderlich, M.2    Yang, D.3
  • 116
    • 63849095591 scopus 로고    scopus 로고
    • Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7
    • Furlan I, Batz C, Flotho C, et al. Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7. Blood. 2009;113(12):2867-2868.
    • (2009) Blood , vol.113 , Issue.12 , pp. 2867-2868
    • Furlan, I.1    Batz, C.2    Flotho, C.3


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