Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

RNA

Volumn 20, Issue 11, 2014, Pages 1789-1802

  Saal, Lena ^a   Briese, Michael ^a   Kneitz, Susanne ^b   Glinka, Michael ^a   Sendtner, Michael ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Axon; Compartment; Motoneuron; Spinal muscular atrophy

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; SURVIVAL MOTOR NEURON PROTEIN; TRANSCRIPTOME; VOLTAGE GATED CALCIUM CHANNEL; SMN1 PROTEIN, MOUSE; SURVIVAL MOTOR NEURON PROTEIN 1;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL ISOLATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENERGY YIELD; GENE ONTOLOGY; GENE SILENCING; GROWTH CONE; IN VITRO STUDY; INTRON; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROARRAY ANALYSIS; MICROFLUIDICS; MOTONEURON; MOUSE; MOUSE EMBRYO; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NERVE FIBER; NERVE FIBER GROWTH; NERVE FIBER TRANSPORT; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; RNA BINDING; RNA DEGRADATION; RNA EXTRACTION; RNA PROCESSING; RNA SPLICING; SPINAL MUSCULAR ATROPHY; SYNAPSE; SYNAPTOSOME; UPREGULATION; ANIMAL; ANIMAL EMBRYO; CELL CULTURE; CELL DIFFERENTIATION; CULTURE TECHNIQUE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; PATHOLOGY;

ANIMALS; AXONS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SURVIVAL OF MOTOR NEURON 1 PROTEIN; TRANSCRIPTOME;

EID: 84908122721     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.047373.114     Document Type: Article

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