Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 48, 2013, Pages 19348-19353

  Zhang, Zhenxi ^a   Pinto, Anna Maria ^a   Wan, Lili ^a   Wang, Wei ^b   Berg, Michael G ^a   Oliva, Isabela ^a   Singh, Larry N ^a   Dengler, Christopher ^a   Wei, Zhi ^b   Dreyfuss, Gideon ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b University Heights   (United States)

Author keywords

C1q complex; Transcriptome perturbations; Z+ (neuronal) agrin

Indexed keywords

AGRIN; CHOLINE ACETYLTRANSFERASE; COMPLEMENT COMPONENT C1Q; SMALL NUCLEAR RIBONUCLEOPROTEIN; SURVIVAL MOTOR NEURON PROTEIN; TRANSCRIPTION FACTOR ER81; TRANSCRIPTOME;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR HORN CELL DISEASE; ARTICLE; ASTROCYTE; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; EXON; GENE CONTROL; MICROGLIA; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SPINAL MUSCULAR ATROPHY; SYNAPSE; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; UPREGULATION; WHITE MATTER;

C1Q COMPLEX; TRANSCRIPTOME PERTURBATIONS; Z+ (NEURONAL) AGRIN;

ANIMALS; BASE SEQUENCE; COMPLEMENT C1Q; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; NEUROGLIA; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA; SMN COMPLEX PROTEINS; SYNAPSES; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84888375636     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1319280110     Document Type: Article

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