Deletion of aryl hydrocarbon receptor AHR in mice leads to subretinal accumulation of microglia and RPE atrophy

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 9, 2014, Pages 6031-6040

  Kim, Soo Young ^a   Chang, Yi Sheng ^a,b   Kim, Jung Woong ^a   Brooks, Matthew ^a   Chew, Emily Y ^a   Wong, Wai T ^a   Fariss, Robert N ^a   Rachel, Rivka A ^a   Cogliati, Tiziana ^a   Qian, Haohua ^a   Swaroop, Anand ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Microglia; Orphan nuclear receptor; Retinal degeneration; RPE atrophy; Subretinal deposits

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; COMPLEMENT FACTOR H; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN; AHR PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ORPHAN NUCLEAR RECEPTOR; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; EYE FUNDUS; FLUORESCENCE ACTIVATED CELL SORTING; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIGHT EXPOSURE; MICROGLIA; MOUSE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHENOTYPE; PIGMENT EPITHELIUM ATROPHY; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; RETINA DEGENERATION; RETINA DETACHMENT; RETINA DISEASE; RETINA ROD; RNA SEQUENCE; SEQUENCE ANALYSIS; SUBRETINAL ACCUMULATION; UPREGULATION; ANIMAL; ATROPHY; C57BL MOUSE; DISEASE MODEL; GENE DELETION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PIGMENT EPITHELIUM; RETINITIS; RPE ATROPHY; SUBRETINAL DEPOSITS;

MICROGLIA; ORPHAN NUCLEAR RECEPTOR; RETINAL DEGENERATION; RPE ATROPHY; SUBRETINAL DEPOSITS;

ANIMALS; ATROPHY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DISEASE MODELS, ANIMAL; FUNDUS OCULI; GENE DELETION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; RECEPTORS, ARYL HYDROCARBON; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS; TOMOGRAPHY, OPTICAL COHERENCE; TRANSCRIPTOME;

EID: 84908093478     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-15091     Document Type: Article

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