Obesity, metabolic dysfunction, and cardiac fibrosis: Pathophysiological pathways, molecular mechanisms, and therapeutic opportunities

Translational Research

Volumn 164, Issue 4, 2014, Pages 323-335

  Cavalera, Michele ^a   Wang, Junhong ^a   Frangogiannis, Nikolaos G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

(PAI) 1 = Plasminogen activator inhibitor 1; (PPAR) = Peroxisome proliferator activated receptor ; (TGF) 1 = Transforming Growth Factor 1; (TSP) 1 = Thrombospondin 1; ACE = Angiotensin converting enzyme; AGEs = Advanced glycation end products; AT1 = Angiotensin type 1; BMI = Body mass index; EndMT = Endothelial mesenchymal transition; ET 1 = Endothelin 1; MMP = Matrix metalloproteinase; RAAS = Renin angiotensin aldosterone system; RAGEs = Receptor for advanced glycation end products; RhoA = Ras homolog gene family member A; ROCK = Rho kinase; ROS = Reactive oxygen species; WT = Wildtype; SMA = smooth muscle actin

Indexed keywords

ADIPONECTIN; ADVANCED GLYCATION END PRODUCT; ENDOTHELIN 1; LEPTIN; RHO KINASE; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

CELLS; FIBROBLAST; FIBROSIS; HEART ATRIUM ARRHYTHMIA; HEART FAILURE; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HYPERVOLEMIA; INCIDENCE; INFLAMMATION; INFLAMMATORY CELL; INSULIN RESISTANCE; LYMPHOCYTE; MACROPHAGE; METABOLIC DISORDER; MOLECULAR MECHANICS; MOLECULAR PATHOLOGY; MONOCYTE; OBESITY; OXIDATIVE STRESS; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; SUDDEN CARDIAC DEATH; UPREGULATION; ANIMAL; HEART DISEASE; HUMAN; PATHOLOGY;

ANIMALS; FIBROSIS; HEART DISEASES; HUMANS; OBESITY;

EID: 84908053819     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2014.05.001     Document Type: Review

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