Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated with Diastolic Stiffness in Type 2 Diabetes

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Hutchinson, Kirk R ^a   Lord, C Kevin ^b   West, T Aaron ^c   Stewart Jr , James A ^d  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF THE INCARNATE WORD   (United States)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; COLLAGEN TYPE 1; GELATINASE A; LEPTIN RECEPTOR; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL STIFFNESS; ARTICLE; BODY WEIGHT; CARDIOMYOPATHY; CELL ISOLATION; COLLAGEN DEGRADATION; CONTROLLED STUDY; CROSS LINKING; DIASTOLE; DIASTOLIC DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART WEIGHT; HYPERGLYCEMIA; MALE; MOUSE; MYOFIBROBLAST; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; POINT MUTATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BLOTTING, WESTERN; CARDIOMYOPATHIES; CELLS, CULTURED; COLLAGEN TYPE I; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; FIBROBLASTS; GLUCOSE; MALE; MICE; MICE, MUTANT STRAINS; MUSCLE, SMOOTH; MYOCARDIUM; MYOFIBROBLASTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFORMING GROWTH FACTOR BETA;

EID: 84882628768     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072080     Document Type: Article

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