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Volumn 8, Issue 5, 2014, Pages e405-e413

Physiological roles of ghrelin on obesity

Author keywords

Ghrelin; Ghrelin O acyl; Prader Willi syndrome; transferase

Indexed keywords

GHRELIN; GHRELIN O ACYL TRANSFERASE; GHRELIN RECEPTOR; OBESTATIN; UNCLASSIFIED DRUG; ACYLTRANSFERASE; GHRELIN O-ACYLTRANSFERASE, HUMAN;

EID: 84908017595     PISSN: 1871403X     EISSN: 18780318     Source Type: Journal    
DOI: 10.1016/j.orcp.2013.10.002     Document Type: Review
Times cited : (52)

References (75)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 0018899801 scopus 로고
    • Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro
    • C.Y. Bowers, F. Momany, G.A. Reynolds, D. Chang, A. Hong, and K. Chang Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro Endocrinology 106 1980 663 667
    • (1980) Endocrinology , vol.106 , pp. 663-667
    • Bowers, C.Y.1    Momany, F.2    Reynolds, G.A.3    Chang, D.4    Hong, A.5    Chang, K.6
  • 3
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
    • C.Y. Bowers, F.A. Momany, G.A. Reynolds, and A. Hong On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone Endocrinology 114 1984 1537 1545
    • (1984) Endocrinology , vol.114 , pp. 1537-1545
    • Bowers, C.Y.1    Momany, F.A.2    Reynolds, G.A.3    Hong, A.4
  • 4
    • 0027322753 scopus 로고
    • Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue
    • K. Cheng, W.W. Chan, B. Butler, L. Wei, W.R. Schoen, and M.J. Wyvratt Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue Endocrinology 132 1993 2729 2731
    • (1993) Endocrinology , vol.132 , pp. 2729-2731
    • Cheng, K.1    Chan, W.W.2    Butler, B.3    Wei, L.4    Schoen, W.R.5    Wyvratt, M.J.6
  • 5
    • 0029129652 scopus 로고
    • Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue
    • A.A. Patchett, R.P. Nargund, J.R. Tata, M.H. Chen, K.J. Barakat, and D.B. Johnston Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue Proc Natl Acad Sci USA 92 1995 7001 7005
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7001-7005
    • Patchett, A.A.1    Nargund, R.P.2    Tata, J.R.3    Chen, M.H.4    Barakat, K.J.5    Johnston, D.B.6
  • 6
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • M. Tschop, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 8
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • J. Yang, M.S. Brown, G. Liang, N.V. Grishin, and J.L. Goldstein Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone Cell 132 2008 387 396
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 9
    • 4344606222 scopus 로고    scopus 로고
    • Genomic structure and characterization of the 5′-flanking region of the human ghrelin gene
    • N. Kanamoto, T. Akamizu, T. Tagami, Y. Hataya, K. Moriyama, and K. Takaya Genomic structure and characterization of the 5′-flanking region of the human ghrelin gene Endocrinology 145 2004 4144 4153
    • (2004) Endocrinology , vol.145 , pp. 4144-4153
    • Kanamoto, N.1    Akamizu, T.2    Tagami, T.3    Hataya, Y.4    Moriyama, K.5    Takaya, K.6
  • 11
    • 0034912651 scopus 로고    scopus 로고
    • Organization of the mouse ghrelin gene and promoter: Occurrence of a short noncoding first exon
    • M. Tanaka, Y. Hayashida, T. Iguchi, N. Nakao, N. Nakai, and K. Nakashima Organization of the mouse ghrelin gene and promoter: occurrence of a short noncoding first exon Endocrinology 142 2001 3697 3700
    • (2001) Endocrinology , vol.142 , pp. 3697-3700
    • Tanaka, M.1    Hayashida, Y.2    Iguchi, T.3    Nakao, N.4    Nakai, N.5    Nakashima, K.6
  • 12
    • 2042504361 scopus 로고    scopus 로고
    • Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels
    • S.V. Angeloni, N. Glynn, G. Ambrosini, M.J. Garant, J.D. Higley, and S. Suomi Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels Endocrinology 145 2004 2197 2205
    • (2004) Endocrinology , vol.145 , pp. 2197-2205
    • Angeloni, S.V.1    Glynn, N.2    Ambrosini, G.3    Garant, M.J.4    Higley, J.D.5    Suomi, S.6
  • 13
    • 0035798584 scopus 로고    scopus 로고
    • Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue
    • H. Kaiya, M. Kojima, H. Hosoda, A. Koda, K. Yamamoto, and Y. Kitajima Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue J Biol Chem 276 2001 40441 40448
    • (2001) J Biol Chem , vol.276 , pp. 40441-40448
    • Kaiya, H.1    Kojima, M.2    Hosoda, H.3    Koda, A.4    Yamamoto, K.5    Kitajima, Y.6
  • 14
    • 0345688712 scopus 로고    scopus 로고
    • Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout
    • H. Kaiya, M. Kojima, H. Hosoda, S. Moriyama, A. Takahashi, and H. Kawauchi Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout Endocrinology 144 2003 5215 5226
    • (2003) Endocrinology , vol.144 , pp. 5215-5226
    • Kaiya, H.1    Kojima, M.2    Hosoda, H.3    Moriyama, S.4    Takahashi, A.5    Kawauchi, H.6
  • 15
    • 0037357065 scopus 로고    scopus 로고
    • Amidated fish ghrelin: Purification, cDNA cloning in the Japanese eel and its biological activity
    • H. Kaiya, M. Kojima, H. Hosoda, L.G. Riley, T. Hirano, and E.G. Grau Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity J Endocrinol 176 2003 415 423
    • (2003) J Endocrinol , vol.176 , pp. 415-423
    • Kaiya, H.1    Kojima, M.2    Hosoda, H.3    Riley, L.G.4    Hirano, T.5    Grau, E.G.6
  • 16
    • 0037860963 scopus 로고    scopus 로고
    • Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus
    • H. Kaiya, M. Kojima, H. Hosoda, L.G. Riley, T. Hirano, and E.G. Grau Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus Comp Biochem Physiol B Biochem Mol Biol 135 2003 421 429
    • (2003) Comp Biochem Physiol B Biochem Mol Biol , vol.135 , pp. 421-429
    • Kaiya, H.1    Kojima, M.2    Hosoda, H.3    Riley, L.G.4    Hirano, T.5    Grau, E.G.6
  • 18
    • 0035755428 scopus 로고    scopus 로고
    • Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus
    • C. Tomasetto, C. Wendling, M.C. Rio, and P. Poitras Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus Peptides 22 2001 2055 2059
    • (2001) Peptides , vol.22 , pp. 2055-2059
    • Tomasetto, C.1    Wendling, C.2    Rio, M.C.3    Poitras, P.4
  • 19
    • 77955174183 scopus 로고    scopus 로고
    • Purification and characterization of caprine ghrelin and its effect on growth hormone release
    • T. Ida, M. Miyazato, X.Z. Lin, H. Kaiya, T. Sato, and K. Nakahara Purification and characterization of caprine ghrelin and its effect on growth hormone release J Mol Neurosci 42 2010 99 105
    • (2010) J Mol Neurosci , vol.42 , pp. 99-105
    • Ida, T.1    Miyazato, M.2    Lin, X.Z.3    Kaiya, H.4    Sato, T.5    Nakahara, K.6
  • 20
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • H. Hosoda, M. Kojima, H. Matsuo, and K. Kangawa Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue Biochem Biophys Res Commun 279 2000 909 913
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 21
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • M. Kojima, and K. Kangawa Ghrelin: structure and function Physiol Rev 85 2005 495 522
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 25
    • 0033867587 scopus 로고    scopus 로고
    • Identification and characterization of a novel gastric peptide hormone: The motilin-related peptide
    • C. Tomasetto, S.M. Karam, S. Ribieras, R. Masson, O. Lefebvre, and A. Staub Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide Gastroenterology 119 2000 395 405
    • (2000) Gastroenterology , vol.119 , pp. 395-405
    • Tomasetto, C.1    Karam, S.M.2    Ribieras, S.3    Masson, R.4    Lefebvre, O.5    Staub, A.6
  • 26
    • 67649210216 scopus 로고    scopus 로고
    • Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor
    • H. Ohgusu, K. Shirouzu, Y. Nakamura, Y. Nakashima, T. Ida, and T. Sato Ghrelin O-acyltransferase (GOAT) has a preference for n-hexanoyl-CoA over n-octanoyl-CoA as an acyl donor Biochem Biophys Res Commun 386 2009 153 158
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 153-158
    • Ohgusu, H.1    Shirouzu, K.2    Nakamura, Y.3    Nakashima, Y.4    Ida, T.5    Sato, T.6
  • 27
    • 20244366719 scopus 로고    scopus 로고
    • Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin
    • Y. Nishi, H. Hiejima, H. Hosoda, H. Kaiya, K. Mori, and Y. Fukue Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin Endocrinology 146 2005 2255 2264
    • (2005) Endocrinology , vol.146 , pp. 2255-2264
    • Nishi, Y.1    Hiejima, H.2    Hosoda, H.3    Kaiya, H.4    Mori, K.5    Fukue, Y.6
  • 28
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • J.V. Zhang, P.G. Ren, O. Avsian-Kretchmer, C.W. Luo, R. Rauch, and C. Klein Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake Science 310 2005 996 999
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3    Luo, C.W.4    Rauch, R.5    Klein, C.6
  • 29
    • 33751019166 scopus 로고    scopus 로고
    • Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents
    • G. Gourcerol, M. Million, D.W. Adelson, Y. Wang, L. Wang, and J. Rivier Lack of interaction between peripheral injection of CCK and obestatin in the regulation of gastric satiety signaling in rodents Peptides 27 2006 2811 2819
    • (2006) Peptides , vol.27 , pp. 2811-2819
    • Gourcerol, G.1    Million, M.2    Adelson, D.W.3    Wang, Y.4    Wang, L.5    Rivier, J.6
  • 31
    • 33846008423 scopus 로고    scopus 로고
    • Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats
    • D. Yamamoto, N. Ikeshita, R. Daito, E.H. Herningtyas, K. Toda, and K. Takahashi Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats Regul Pept 138 2007 141 144
    • (2007) Regul Pept , vol.138 , pp. 141-144
    • Yamamoto, D.1    Ikeshita, N.2    Daito, R.3    Herningtyas, E.H.4    Toda, K.5    Takahashi, K.6
  • 32
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Y. Date, M. Kojima, H. Hosoda, A. Sawaguchi, M.S. Mondal, and T. Suganuma Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans Endocrinology 141 2000 4255 4261
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6
  • 33
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Y. Date, M. Nakazato, S. Hashiguchi, K. Dezaki, M.S. Mondal, and H. Hosoda Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion Diabetes 51 2002 124 129
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3    Dezaki, K.4    Mondal, M.S.5    Hosoda, H.6
  • 34
    • 18844421372 scopus 로고    scopus 로고
    • Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration
    • T. Sato, Y. Fukue, H. Teranishi, Y. Yoshida, and M. Kojima Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration Endocrinology 146 2005 2510 2516
    • (2005) Endocrinology , vol.146 , pp. 2510-2516
    • Sato, T.1    Fukue, Y.2    Teranishi, H.3    Yoshida, Y.4    Kojima, M.5
  • 35
    • 0033784980 scopus 로고    scopus 로고
    • Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats
    • A.K. Hewson, and S.L. Dickson Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats J Neuroendocrinol 12 2000 1047 1049
    • (2000) J Neuroendocrinol , vol.12 , pp. 1047-1049
    • Hewson, A.K.1    Dickson, S.L.2
  • 36
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Y. Date, N. Murakami, K. Toshinai, S. Matsukura, A. Niijima, and H. Matsuo The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats Gastroenterology 123 2002 1120 1128
    • (2002) Gastroenterology , vol.123 , pp. 1120-1128
    • Date, Y.1    Murakami, N.2    Toshinai, K.3    Matsukura, S.4    Niijima, A.5    Matsuo, H.6
  • 37
    • 0344394289 scopus 로고    scopus 로고
    • Vagotomy dissociates short- and long-term controls of circulating ghrelin
    • D.L. Williams, H.J. Grill, D.E. Cummings, and J.M. Kaplan Vagotomy dissociates short- and long-term controls of circulating ghrelin Endocrinology 144 2003 5184 5187
    • (2003) Endocrinology , vol.144 , pp. 5184-5187
    • Williams, D.L.1    Grill, H.J.2    Cummings, D.E.3    Kaplan, J.M.4
  • 38
    • 33748946416 scopus 로고    scopus 로고
    • Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus
    • Y. Date, T. Shimbara, S. Koda, K. Toshinai, T. Ida, and N. Murakami Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus Cell Metab 4 2006 323 331
    • (2006) Cell Metab , vol.4 , pp. 323-331
    • Date, Y.1    Shimbara, T.2    Koda, S.3    Toshinai, K.4    Ida, T.5    Murakami, N.6
  • 39
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • M.A. Cowley, R.G. Smith, S. Diano, M. Tschop, N. Pronchuk, and K.L. Grove The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 37 2003 649 661
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6
  • 40
    • 0842324779 scopus 로고    scopus 로고
    • Obesity wars: Molecular progress confronts an expanding epidemic
    • J.S. Flier Obesity wars: molecular progress confronts an expanding epidemic Cell 116 2004 337 350
    • (2004) Cell , vol.116 , pp. 337-350
    • Flier, J.S.1
  • 41
    • 0036083399 scopus 로고    scopus 로고
    • Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats
    • E. Adeghate, and A.S. Ponery Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats J Neuroendocrinol 14 2002 555 560
    • (2002) J Neuroendocrinol , vol.14 , pp. 555-560
    • Adeghate, E.1    Ponery, A.S.2
  • 42
    • 0036141195 scopus 로고    scopus 로고
    • Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: Enteric distribution, ontogeny, influence of endocrine, and dietary manipulations
    • H.M. Lee, G. Wang, E.W. Englander, M. Kojima, and G.H. Greeley Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations Endocrinology 143 2002 185 190
    • (2002) Endocrinology , vol.143 , pp. 185-190
    • Lee, H.M.1    Wang, G.2    Englander, E.W.3    Kojima, M.4    Greeley, G.H.5
  • 43
    • 0037372044 scopus 로고    scopus 로고
    • Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    • M.K. Reimer, G. Pacini, and B. Ahren Dose-dependent inhibition by ghrelin of insulin secretion in the mouse Endocrinology 144 2003 916 921
    • (2003) Endocrinology , vol.144 , pp. 916-921
    • Reimer, M.K.1    Pacini, G.2    Ahren, B.3
  • 44
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • F. Broglio, E. Arvat, A. Benso, C. Gottero, G. Muccioli, and M. Papotti Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans J Clin Endocrinol Metab 86 2001 5083 5086
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3    Gottero, C.4    Muccioli, G.5    Papotti, M.6
  • 45
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    • K. Dezaki, H. Sone, M. Koizumi, M. Nakata, M. Kakei, and H. Nagai Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance Diabetes 55 2006 3486 3493
    • (2006) Diabetes , vol.55 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6
  • 46
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 48
    • 2642570058 scopus 로고    scopus 로고
    • Optimum collection and storage conditions for ghrelin measurements: Octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples
    • H. Hosoda, K. Doi, N. Nagaya, H. Okumura, E. Nakagawa, and M. Enomoto Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples Clin Chem 50 2004 1077 1080
    • (2004) Clin Chem , vol.50 , pp. 1077-1080
    • Hosoda, H.1    Doi, K.2    Nagaya, N.3    Okumura, H.4    Nakagawa, E.5    Enomoto, M.6
  • 50
    • 0021351281 scopus 로고
    • Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP)
    • K. Kangawa, and H. Matsuo Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP) Biochem Biophys Res Commun 118 1984 131 139
    • (1984) Biochem Biophys Res Commun , vol.118 , pp. 131-139
    • Kangawa, K.1    Matsuo, H.2
  • 51
    • 0023867456 scopus 로고
    • A new natriuretic peptide in porcine brain
    • T. Sudoh, K. Kangawa, N. Minamino, and H. Matsuo A new natriuretic peptide in porcine brain Nature 332 1988 78 81
    • (1988) Nature , vol.332 , pp. 78-81
    • Sudoh, T.1    Kangawa, K.2    Minamino, N.3    Matsuo, H.4
  • 53
    • 2442515963 scopus 로고    scopus 로고
    • Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes
    • M.J. Iglesias, R. Pineiro, M. Blanco, R. Gallego, C. Dieguez, and O. Gualillo Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes Cardiovasc Res 62 2004 481 488
    • (2004) Cardiovasc Res , vol.62 , pp. 481-488
    • Iglesias, M.J.1    Pineiro, R.2    Blanco, M.3    Gallego, R.4    Dieguez, C.5    Gualillo, O.6
  • 57
    • 1042267409 scopus 로고    scopus 로고
    • Prader-Willi syndrome: Advances in genetics, pathophysiology and treatment
    • A.P. Goldstone Prader-Willi syndrome: advances in genetics, pathophysiology and treatment Trends Endocrinol Metab 15 2004 12 20
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 12-20
    • Goldstone, A.P.1
  • 58
    • 77957274035 scopus 로고    scopus 로고
    • Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
    • D.I. Briggs, P.J. Enriori, M.B. Lemus, M.A. Cowley, and Z.B. Andrews Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons Endocrinology 151 2002 4745 4755
    • (2002) Endocrinology , vol.151 , pp. 4745-4755
    • Briggs, D.I.1    Enriori, P.J.2    Lemus, M.B.3    Cowley, M.A.4    Andrews, Z.B.5
  • 59
    • 0035777024 scopus 로고    scopus 로고
    • Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes
    • R.D. Nicholls, and J.L. Knepper Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes Annu Rev Genomics Hum Genet 2 2001 153 175
    • (2001) Annu Rev Genomics Hum Genet , vol.2 , pp. 153-175
    • Nicholls, R.D.1    Knepper, J.L.2
  • 62
    • 24344441965 scopus 로고    scopus 로고
    • Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome
    • Y.H. Choe, S.Y. Song, K.H. Paik, Y.J. Oh, S.H. Chu, and S.H. Yeo Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome J Clin Endocrinol Metab 90 2005 5441 5445
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5441-5445
    • Choe, Y.H.1    Song, S.Y.2    Paik, K.H.3    Oh, Y.J.4    Chu, S.H.5    Yeo, S.H.6
  • 63
    • 1542300099 scopus 로고    scopus 로고
    • Molecular screening of the ghrelin gene in Italian obese children: The Leu72Met variant is associated with an earlier onset of obesity
    • E. Miraglia del Giudice, N. Santoro, G. Cirillo, P. Raimondo, A. Grandone, and A. D'Aniello Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity Int J Obes Relat Metab Disord 28 2004 447 450
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 447-450
    • Miraglia Del Giudice, E.1    Santoro, N.2    Cirillo, G.3    Raimondo, P.4    Grandone, A.5    D'Aniello, A.6
  • 64
    • 0037955956 scopus 로고    scopus 로고
    • Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects
    • S. Poykko, O. Ukkola, H. Kauma, M.J. Savolainen, and Y.A. Kesaniemi Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects Diabetologia 46 2003 455 458
    • (2003) Diabetologia , vol.46 , pp. 455-458
    • Poykko, S.1    Ukkola, O.2    Kauma, H.3    Savolainen, M.J.4    Kesaniemi, Y.A.5
  • 69
    • 36949026161 scopus 로고    scopus 로고
    • The anti-ghrelin Spiegelmer NOX-B11-3 blocks ghrelin- but not fasting-induced neuronal activation in the hypothalamic arcuate nucleus
    • C. Becskei, K.U. Bilik, S. Klussmann, F. Jarosch, T.A. Lutz, and T. Riediger The anti-ghrelin Spiegelmer NOX-B11-3 blocks ghrelin- but not fasting-induced neuronal activation in the hypothalamic arcuate nucleus J Neuroendocrinol 20 2008 85 92
    • (2008) J Neuroendocrinol , vol.20 , pp. 85-92
    • Becskei, C.1    Bilik, K.U.2    Klussmann, S.3    Jarosch, F.4    Lutz, T.A.5    Riediger, T.6
  • 70
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • A. Asakawa, A. Inui, T. Kaga, G. Katsuura, M. Fujimiya, and M.A. Fujino Antagonism of ghrelin receptor reduces food intake and body weight gain in mice Gut 52 2003 947 952
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6
  • 71
    • 7644219561 scopus 로고    scopus 로고
    • Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats
    • B. Beck, S. Richy, and A. Stricker-Krongrad Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats Life Sci 76 2004 473 478
    • (2004) Life Sci , vol.76 , pp. 473-478
    • Beck, B.1    Richy, S.2    Stricker-Krongrad, A.3
  • 72
    • 35348825010 scopus 로고    scopus 로고
    • Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity
    • J. Rudolph, W.P. Esler, S. O'Connor, P.D. Coish, P.L. Wickens, and M. Brands Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity J Med Chem 50 2007 5202 5216
    • (2007) J Med Chem , vol.50 , pp. 5202-5216
    • Rudolph, J.1    Esler, W.P.2    O'Connor, S.3    Coish, P.D.4    Wickens, P.L.5    Brands, M.6
  • 73
    • 35548949948 scopus 로고    scopus 로고
    • Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss
    • W.P. Esler, J. Rudolph, T.H. Claus, W. Tang, N. Barucci, and S.E. Brown Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss Endocrinology 148 2007 5175 5185
    • (2007) Endocrinology , vol.148 , pp. 5175-5185
    • Esler, W.P.1    Rudolph, J.2    Claus, T.H.3    Tang, W.4    Barucci, N.5    Brown, S.E.6
  • 74
    • 1342264249 scopus 로고    scopus 로고
    • Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
    • B. Holst, and T.W. Schwartz Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation Trends Pharmacol Sci 25 2004 113 117
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 113-117
    • Holst, B.1    Schwartz, T.W.2
  • 75
    • 78650304822 scopus 로고    scopus 로고
    • Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor
    • B.P. Barnett, Y. Hwang, M.S. Taylor, H. Kirchner, P.T. Pfluger, and V. Bernard Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor Science 330 2010 1689 1692
    • (2010) Science , vol.330 , pp. 1689-1692
    • Barnett, B.P.1    Hwang, Y.2    Taylor, M.S.3    Kirchner, H.4    Pfluger, P.T.5    Bernard, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.