Peptide Purification, Complementary Deoxyribonucleic Acid (DNA) and Genomic DNA Cloning, and Functional Characterization of Ghrelin in Rainbow Trout

Endocrinology

Volumn 144, Issue 12, 2003, Pages 5215-5226

  Kaiya, Hiroyuki ^a   Kojima, Masayasu ^b   Hosoda, Hiroshi ^a   Moriyama, Shunsuke ^c   Takahashi, Akiyoshi ^c   Kawauchi, Hiroshi ^c   Kangawa, Kenji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b KURUME UNIVERSITY   (Japan)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; DECANOIC ACID; GENOMIC DNA; GHRELIN; GLYCINE; GLYCYLSERYLSERYLPHENYLALANYLLEUCYLSERYLPROLYLSERYLGLUTAMINYLLYSYLPROLYLGLUT AMINYLVALYLARGINYLGLUTAMINYLGLYCYLLYSYLGLYCYLLYSYLPROLYLPROLYLARGINYLVALINAMIDE; GROWTH HORMONE; ISOPROTEIN; MESSENGER RNA; OCTANOIC ACID; PROLACTIN; SERINE; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

AMIDATION; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY GROWTH; BRAIN; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CONTROLLED STUDY; EXON; FEMALE; GENE DELETION; GROWTH HORMONE RELEASE; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; INTRON; MALE; MOLECULAR CLONING; MOLECULE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOREGULATION; PREDICTION; PRIORITY JOURNAL; PROLACTIN RELEASE; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN MODIFICATION; PROTEIN PURIFICATION; RAINBOW TROUT; RAT; REGULATOR GENE; RNA SPLICING; STOMACH; TISSUE LEVEL;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; DNA, COMPLEMENTARY; FISH PROTEINS; GENE EXPRESSION; GLYCOPROTEINS; GROWTH HORMONE; INJECTIONS, INTRAPERITONEAL; MOLECULAR SEQUENCE DATA; ONCORHYNCHUS MYKISS; PEPTIDE HORMONES; PITUITARY GLAND; PITUITARY HORMONES; PROLACTIN; RNA, MESSENGER; STOMACH;

EID: 0345688712     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1085     Document Type: Article

References (37)

1. Kojima M, Hosoda H, Date Y, Nakazato, M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
2. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchtt AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
3. McKee KK, Palyha OC, Feighner SD, Hreniuk DL, Tan CP, Phillips MS, Smith RG, Van der Ploeg LH, Howard AD 1997 Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol 11:415-423
4. 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. J Endocrinol Invest 24:RC7-RC9
5. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
6. Seoane LM, Tovar S, Baldelli R, Arvat E, Ghigo E, Casanueva FF, Dieguez C 2000 Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats. Eur J Endocrinol 143:R7-R9
7. Tolle V, Zizzari P, Tomasetto C, Rio MC, Epelbaum J, Bluet-Pajot MT 2001 In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 73:54-61
8. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M 2000 Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 275:477-480
9. Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K, Arvat E, Ghigo E, Dieguez C, Casanueva FF 2000 Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 143:R11-R14
10. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K 2000 Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908-4911
11. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M 2002 The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gasrroenterology 123:1120-1128
12. Tamura H, Kamegai J, Shimizu T, Ishii S, Sugihara H, Oikawa S 2002 Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology 143:3268-3275
13. Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H, Kamegai J, Sugihara H, Oikawa S, Wakabayashi I 2002 Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. J Clin Invest 109:1429-1436
14. Peng C, Peter RE 1997 Neuroendocrine regulation of growth hormone secretion and growth in fish. Zool Studies 36:79-89
15. Montero M, Yon L, Rousseau K, Arimura A, Fournier A, Dufour S, Vaudry H 1998 Distribution, characterization, and growth hormone-releasing activity of pituitary adenylate cyclase-activating polypeptide in the European eel, Anguilla anguilla. Endocrinology 139:4300-4310
16. Shepherd BS, Eckert SM, Parhar IS, Vijayan MM, Wakabayashi I, Hirano T, Grau EG, Chen TT 2000 The hexapeptide KP-102 (D-Ala-D-B-Nal-Ala-Trp-D-Phe-Lys- NH2) stimulates growth hormone release in a cichlid fish (Oreochromis mossambicus). J Endocrinol 167:R7-R10
17. Unniappan S, Lin X, Cervini L, Rivier J, Kaiya H, Kangawa K, Peter RE 2002 Goldfish ghrelin: molecular characterization of the complementary deoxyribonucleic acid, partial gene structure and evidence for its stimulatory role in food intake. Endocrinology 143:4143-4146
18. Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, Kangawa K 2003 Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity. J Endocrinol 176:415-423
19. Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, Kangawa K 2003 Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol B 135:421-429
20. Kaiya H, Kojima M, Hosoda H, Koda A, Yamamoto K, Kitajima Y, Matsumoto M, Minamitake Y, Kikuyama S, Kangawa K 2001 Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Biol Chem 276: 40441-40448
21. Kaiya H, Van Der Geyten S, Kojima M, Hosoda H, Kitajima Y, Matsumoto M, Geelissen S, Darras VM, Kangawa K 2002 Chicken ghrelin: purification, cDNA cloning and biological activity. Endocrinology 143:3454-3463
22. Riley LG, Hirano T, Grau EG 2002 Rat ghrelin stimulates growth hormone and prolactin release in the tilapia, Oreochromis mossambicus. Zoolog Sci 19:797-800
23. Matsumoto M, Hosoda H, Kitajima Y, Morozumi N, Minamitake Y, Tanaka S, Matsuo H, Kojima M, Hayashi Y, Kangawa K 2001 Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. Biochem Biophys Res Commun 287:142-146
24. Moriyama S, Ho T, Takahashi A, Amano M, Sower SA, Hirano T, Yamamori K, Kawauchi H 2002 A homolog of mammalian PRL-releasing peptide (fish arginyl-phenylalanyl-amide peptide) is a major hypothalamic peptide of PRL release in teleost fish. Endocrinology 143:2071-2079
25. Bolton JP, Takahashi A, Kawauchi H, Kubota J, Hirano T 1986 Development and validation of a salmon growth hormone radioimmunoassay. Gen Comp Endocrinol 62:230-238
26. Hirano T, Prunet P, Kawauchi H, Takahashi A, Ogasawara T, Kubota J, Nishioka RS, Bern HA, Takada K, Ishii S 1985 Development and validation of a salmon prolactin radioimmunoassay. Gen Comp Endocrinol 59:266-276
27. Kakizawa S, Kaneko T, Hasegawa S, Hirano T 1993 Activation of somatolactin cells in the pituitary of the rainbow trout Oncorhynchus mykiss by low environmental calcium. Gen Comp Endocrinol 91:298-306
28. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K 2003 Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem 278:64-70
29. Hosoda H, Kojima M, Matsuo H, Kangawa K 2000 Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem 275:21995-22000
30. Tanaka M, Hayashida Y, Iguchi T, Nakao N, Nakai N, Nakashima K 2001 Organization of the mouse ghrelin gene and promoter: occurrence of a short noncoding first exon. Endocrinology 142:3697-3700
31. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001 A role for ghrelin in the central regulation of feeding. Nature 409:194-198
32. Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H, Yahata K, Mukoyama M, Sugawara A, Hosoda H, Kojima M, Kangawa K, Nakao K 2000 Kidney produces a novel acylated peptide, ghrelin. FEBS Lett 486:213-216
33. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M 2002 The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87:2988-2991
34. Sakamoto T, Uchida K, Yokota S 2001 Regulation of the ion-transporting mitochondrion-rich cell during adaptation of teleost fishes to different salinities. Zoolog Sci 18:1163-1174
35. McCormick SD 2001 Endocrine control of osmoregulation in teleost fish. Amer Zool 41:781-794
36. Kozaka T, Fujii Y, Ando M 2003 Central effects of various ligands on drinking behavior in eels acclimated to seawater. J Exp Biol 206:687-692
37. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K 2001 Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol 280:R1483-R1487