메뉴 건너뛰기




Volumn 145, Issue 9, 2004, Pages 4144-4153

Genomic structure and characterization of the 5′-flanking region of the human ghrelin gene

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GHRELIN; REGULATOR PROTEIN;

EID: 4344606222     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1718     Document Type: Article
Times cited : (79)

References (71)
  • 1
    • 0033986128 scopus 로고    scopus 로고
    • Getting to the guts of enteroendocrine differentiation
    • Skipper M, Lewis J 2000 Getting to the guts of enteroendocrine differentiation. Nat Genet 24:3-4
    • (2000) Nat Genet , vol.24 , pp. 3-4
    • Skipper, M.1    Lewis, J.2
  • 2
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 3
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M 2000 Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141: 4255-4261
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 4
    • 0035097594 scopus 로고    scopus 로고
    • The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors
    • Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB 2001 The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 86:881-887
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 881-887
    • Korbonits, M.1    Bustin, S.A.2    Kojima, M.3    Jordan, S.4    Adams, E.F.5    Lowe, D.G.6    Kangawa, K.7    Grossman, A.B.8
  • 11
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 15
    • 0035143816 scopus 로고    scopus 로고
    • Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K 2001 Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50:227-232
    • (2001) Diabetes , vol.50 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3    Aizawa-Abe, M.4    Miyanaga, F.5    Takaya, K.6    Hayashi, T.7    Inoue, G.8    Hosoda, K.9    Kojima, M.10    Kangawa, K.11    Nakao, K.12
  • 21
    • 0037220691 scopus 로고    scopus 로고
    • Plasma ghrelin concentrations are not regulated by glucose or insulin: A double-blind, placebo-controlled crossover clamp study
    • Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M, Luger A 2003 Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo-controlled crossover clamp study. Diabetes 52:16-20
    • (2003) Diabetes , vol.52 , pp. 16-20
    • Schaller, G.1    Schmidt, A.2    Pleiner, J.3    Woloszczuk, W.4    Wolzt, M.5    Luger, A.6
  • 27
    • 0003128327 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma
    • Braverman LE, Utiger RD, eds. Philadelphia: Lippincott Williams & Wilkins;
    • Ball DW, Baylin SB, De Bustros AC 2000 Medullary thyroid carcinoma. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 536-553
    • (2000) Werner and Ingbar's the Thyroid. 8th Ed. , pp. 536-553
    • Ball, D.W.1    Baylin, S.B.2    De Bustros, A.C.3
  • 30
    • 0031034065 scopus 로고    scopus 로고
    • Characterisation of thyroid medullary carcinoma TT cell line
    • Zabel M, Grzeszkowiak J 1997 Characterisation of thyroid medullary carcinoma TT cell line. Histol Histopathol 12:283-289
    • (1997) Histol Histopathol , vol.12 , pp. 283-289
    • Zabel, M.1    Grzeszkowiak, J.2
  • 31
    • 0024212067 scopus 로고
    • Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer
    • Frohman MA, Dush MK, Martin GR 1988 Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc Natl Acad Sci USA 85:8998-9002
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 8998-9002
    • Frohman, M.A.1    Dush, M.K.2    Martin, G.R.3
  • 32
    • 0029152189 scopus 로고
    • cRACE: A simple method for identification of the 5′ end of mRNAs
    • Maruyama IN, Rakow TL, Maruyama HI 1995 cRACE: a simple method for identification of the 5′ end of mRNAs. Nucleic Acids Res 23:3796-3797
    • (1995) Nucleic Acids Res , vol.23 , pp. 3796-3797
    • Maruyama, I.N.1    Rakow, T.L.2    Maruyama, H.I.3
  • 36
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • Hosoda H, Kojima M, Matsuo H, Kangawa K 2000 Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279:909-913
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 37
    • 0037011171 scopus 로고    scopus 로고
    • Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
    • Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, Jensen J, Kedinger M, Gradwohl G 2002 Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J 21:6338-6347
    • (2002) EMBO J , vol.21 , pp. 6338-6347
    • Jenny, M.1    Uhl, C.2    Roche, C.3    Duluc, I.4    Guillermin, V.5    Guillemot, F.6    Jensen, J.7    Kedinger, M.8    Gradwohl, G.9
  • 38
    • 0034912651 scopus 로고    scopus 로고
    • Organization of the mouse ghrelin gene and promoter: Occurrence of a short noncoding first exon
    • Tanaka M, Hayashida Y, Iguchi T, Nakao N, Nakai N, Nakashima K 2001 Organization of the mouse ghrelin gene and promoter: occurrence of a short noncoding first exon. Endocrinology 142:3697-3700
    • (2001) Endocrinology , vol.142 , pp. 3697-3700
    • Tanaka, M.1    Hayashida, Y.2    Iguchi, T.3    Nakao, N.4    Nakai, N.5    Nakashima, K.6
  • 41
    • 0018570080 scopus 로고
    • Morphology and function of the entero-endocrine cells
    • Grube D, Forssmann WG 1979 Morphology and function of the entero-endocrine cells. Horm Metab Res 11:589-606
    • (1979) Horm Metab Res , vol.11 , pp. 589-606
    • Grube, D.1    Forssmann, W.G.2
  • 43
    • 0022585306 scopus 로고
    • Secretion of chromogranin a by peptide-producing endocrine neoplasms
    • O'Connor DT, Deftos LJ 1986 Secretion of chromogranin A by peptide-producing endocrine neoplasms. N Engl J Med 314:1145-1151
    • (1986) N Engl J Med , vol.314 , pp. 1145-1151
    • O'Connor, D.T.1    Deftos, L.J.2
  • 45
    • 0025793164 scopus 로고
    • Chromogranin A: Its role in endocrine function and as an endocrine and neuroendocrine tumor marker
    • Deftos LJ 1991 Chromogranin A: its role in endocrine function and as an endocrine and neuroendocrine tumor marker. Endocr Rev 12:181-187
    • (1991) Endocr Rev , vol.12 , pp. 181-187
    • Deftos, L.J.1
  • 46
    • 0033883069 scopus 로고    scopus 로고
    • Doing the MATH: Is the mouse a good model for fly development?
    • Hassan BA, Bellen HJ 2000 Doing the MATH: is the mouse a good model for fly development? Genes Dev 14:1852-1865
    • (2000) Genes Dev , vol.14 , pp. 1852-1865
    • Hassan, B.A.1    Bellen, H.J.2
  • 47
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • Massari ME, Murre C 2000 Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20:429-440
    • (2000) Mol Cell Biol , vol.20 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 48
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M, Guillemot F 2000 Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    Lemeur, M.3    Guillemot, F.4
  • 50
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY 2001 Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294:2155-2158
    • (2001) Science , vol.294 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3    Zoghbi, H.Y.4
  • 51
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    • Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ 1997 Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11:2323-2334
    • (1997) Genes Dev , vol.11 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.P.2    Qiu, Y.3    Mutoh, H.4    Demayo, F.J.5    Leiter, A.B.6    Tsai, M.J.7
  • 52
    • 0032521448 scopus 로고    scopus 로고
    • The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells
    • Mutoh H, Naya FJ, Tsai MJ, Leiter AB 1998 The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev 12:820-830
    • (1998) Genes Dev , vol.12 , pp. 820-830
    • Mutoh, H.1    Naya, F.J.2    Tsai, M.J.3    Leiter, A.B.4
  • 53
    • 0037088594 scopus 로고    scopus 로고
    • Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD
    • Ratineau C, Petry MW, Mutoh H, Leiter AB 2002 Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem 277:8847-8853
    • (2002) J Biol Chem , vol.277 , pp. 8847-8853
    • Ratineau, C.1    Petry, M.W.2    Mutoh, H.3    Leiter, A.B.4
  • 54
    • 0022374891 scopus 로고
    • Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region
    • Sawadogo M, Roeder RG 1985 Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell 43:165-175
    • (1985) Cell , vol.43 , pp. 165-175
    • Sawadogo, M.1    Roeder, R.G.2
  • 55
    • 0022427811 scopus 로고
    • Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter
    • Miyamoto NG, Moncollin V, Egly JM, Chambon P 1985 Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter. EMBO J 4:3563-3570
    • (1985) EMBO J , vol.4 , pp. 3563-3570
    • Miyamoto, N.G.1    Moncollin, V.2    Egly, J.M.3    Chambon, P.4
  • 56
    • 0023752096 scopus 로고
    • Multiple forms of the human gene-specific transcription factor USF. I. Complete purification and identification of USF from HeLa cell nuclei
    • Sawadogo M, Van Dyke MW, Gregor PD, Roeder RG 1988 Multiple forms of the human gene-specific transcription factor USF. I. Complete purification and identification of USF from HeLa cell nuclei. J Biol Chem 263:11985-11993
    • (1988) J Biol Chem , vol.263 , pp. 11985-11993
    • Sawadogo, M.1    Van Dyke, M.W.2    Gregor, P.D.3    Roeder, R.G.4
  • 57
    • 0025084602 scopus 로고
    • The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer
    • Gregor PD, Sawadogo M, Roeder RG 1990 The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer. Genes Dev 4:1730-1740
    • (1990) Genes Dev , vol.4 , pp. 1730-1740
    • Gregor, P.D.1    Sawadogo, M.2    Roeder, R.G.3
  • 58
    • 0028050025 scopus 로고
    • 2 on specificity and comparison with binding of Myc family members
    • 2 on specificity and comparison with binding of Myc family members. Nucleic Acids Res 22:2801-2810
    • (1994) Nucleic Acids Res , vol.22 , pp. 2801-2810
    • Bendall, A.J.1    Molloy, P.L.2
  • 59
    • 23444453049 scopus 로고
    • Ubiquitous expression of the 43-and 44-kDa forms of transcription factor USF in mammalian cells
    • Sirito M, Lin Q, Maity T, Sawadogo M 1994 Ubiquitous expression of the 43-and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res 22:427-433
    • (1994) Nucleic Acids Res , vol.22 , pp. 427-433
    • Sirito, M.1    Lin, Q.2    Maity, T.3    Sawadogo, M.4
  • 60
    • 0030850183 scopus 로고    scopus 로고
    • Binding of upstream stimulatory factor and a cell-specific activator to the calcitonin/calcitonin gene-related peptide enhancer
    • Lanigan TM, Russo AF 1997 Binding of upstream stimulatory factor and a cell-specific activator to the calcitonin/calcitonin gene-related peptide enhancer. J Biol Chem 272:18316-18324
    • (1997) J Biol Chem , vol.272 , pp. 18316-18324
    • Lanigan, T.M.1    Russo, A.F.2
  • 61
    • 0029731416 scopus 로고    scopus 로고
    • Transcription of the transforming growth factor-β2 gene is dependent on an E-box located between an essential cAMP response element/activating transcription factor motif and the TATA box of the gene
    • Scholtz B, Kingsley-Kallesen M, Rizzino A 1996 Transcription of the transforming growth factor-β2 gene is dependent on an E-box located between an essential cAMP response element/activating transcription factor motif and the TATA box of the gene. J Biol Chem 271:32375-32380
    • (1996) J Biol Chem , vol.271 , pp. 32375-32380
    • Scholtz, B.1    Kingsley-Kallesen, M.2    Rizzino, A.3
  • 62
    • 0030060942 scopus 로고    scopus 로고
    • Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF
    • Sharma S, Leonard J, Lee S, Chapman HD, Leiter EH, Montminy MR 1996 Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF. J Biol Chem 271:2294-2299
    • (1996) J Biol Chem , vol.271 , pp. 2294-2299
    • Sharma, S.1    Leonard, J.2    Lee, S.3    Chapman, H.D.4    Leiter, E.H.5    Montminy, M.R.6
  • 63
    • 0033565925 scopus 로고    scopus 로고
    • Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic β-cells
    • Qian J, Kaytor EN, Towle HC, Olson LK 1999 Upstream stimulatory factor regulates Pdx-1 gene expression in differentiated pancreatic β-cells. Biochem J 341:315-322
    • (1999) Biochem J , vol.341 , pp. 315-322
    • Qian, J.1    Kaytor, E.N.2    Towle, H.C.3    Olson, L.K.4
  • 64
    • 0023448190 scopus 로고
    • The major late transcription factor binds to and activates the mouse metallothionein I promoter
    • Carthew RW, Chodosh LA, Sharp PA 1987 The major late transcription factor binds to and activates the mouse metallothionein I promoter. Genes Dev 1:973-980
    • (1987) Genes Dev , vol.1 , pp. 973-980
    • Carthew, R.W.1    Chodosh, L.A.2    Sharp, P.A.3
  • 65
    • 0023619655 scopus 로고
    • The adenovirus major late transcription factor activates the rat γ-fibrinogen promoter
    • Chodosh LA, Carthew RW, Morgan JG, Sharp PA 1987 The adenovirus major late transcription factor activates the rat γ-fibrinogen promoter. Science 238: 684-688
    • (1987) Science , vol.238 , pp. 684-688
    • Chodosh, L.A.1    Carthew, R.W.2    Morgan, J.G.3    Sharp, P.A.4
  • 66
    • 0033002078 scopus 로고    scopus 로고
    • Differential activation of the SMαA promoter in smooth vs. skeletal muscle cells by bHLH factors
    • Johnson AD, Owens GK 1999 Differential activation of the SMαA promoter in smooth vs. skeletal muscle cells by bHLH factors. Am J Physiol 276:C1420-C1431
    • (1999) Am J Physiol , vol.276
    • Johnson, A.D.1    Owens, G.K.2
  • 67
    • 0027235826 scopus 로고
    • Evidence that the transcription factor USF is a component of the human β-globin locus control region heteromeric protein complex
    • Bresnick EH, Felsenfeld G 1993 Evidence that the transcription factor USF is a component of the human β-globin locus control region heteromeric protein complex. J Biol Chem 268:18824-18834
    • (1993) J Biol Chem , vol.268 , pp. 18824-18834
    • Bresnick, E.H.1    Felsenfeld, G.2
  • 68
    • 0003875303 scopus 로고    scopus 로고
    • Cloning and characterization of the 5′-flanking region for the human topoisomerase III gene
    • Kim JC, Yoon JB, Koo HS, Chung IK 1998 Cloning and characterization of the 5′-flanking region for the human topoisomerase III gene. J Biol Chem 273: 26130-26137
    • (1998) J Biol Chem , vol.273 , pp. 26130-26137
    • Kim, J.C.1    Yoon, J.B.2    Koo, H.S.3    Chung, I.K.4
  • 69
    • 1842375053 scopus 로고    scopus 로고
    • Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter
    • Wang D, Sul HS 1997 Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter. J Biol Chem 272:26367-26374
    • (1997) J Biol Chem , vol.272 , pp. 26367-26374
    • Wang, D.1    Sul, H.S.2
  • 71
    • 0026680845 scopus 로고
    • Interaction cloning: Identification of a helix-loop-helix zipper protein that interacts with c-Fos
    • Blanar MA, Rutter WJ 1992 Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science 256:1014-1018
    • (1992) Science , vol.256 , pp. 1014-1018
    • Blanar, M.A.1    Rutter, W.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.