Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity

Tetrahedron

Volumn 70, Issue 45, 2014, Pages 8462-8473

  Thakur, Ravi Kumar ^a   Mishra, Akansha ^a   Ramakrishna, K K G ^a   Mahar, Rohit ^a   Shukla, Sanjeev K ^a,b   Srivastava, A K ^a,b   Tripathi, Rama P ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

Azido sugars; Pyrimidine nucleosides; Triazoles; Glucosidase

Indexed keywords

1 [[1' (2",3",4",6" TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (2",3",4",6" TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (5" DEOXY 1",2" O ISOPROPYLIDENE ALPHA DEXTRO XYLOFURANOS 5" YL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (6" DEOXY 1",2":3",4" DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6" YL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (BETA DEXTRO GALACTOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL] 5 METHYL PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (BETA DEXTRO GALACTOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL] METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[1' (BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL] 5 METHYL PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[[[1' (1",6" DIDEOXY 2",3",4" TRI O ACETYL BETA DEXTRO GALACTOPYRANOS 1" YL)PROPAN 2"' ONE] 6" YL] 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1 [[[[1' (1",6" DIDEOXY BETA DEXTRO GLUCOPYRANOS 1" YL)PROPAN 2"' ONE] 6" YL] 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (2",3",4",6" TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL] 5 METHYL PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (2",3",4",6" TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (2",3",4",6" TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL] 5 METHYL PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (2",3",4",6" TETRA O ACETYL BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (5" DEOXY 1",2" O ISOPROPYLIDENE ALPHA DEXTRO XYLOFURANOS 5" YL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (6" DEOXY 1",2";3",4" DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6" YL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (BETA DEXTRO GALACTOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL] 5 METHYL PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[1' (BETA DEXTRO GLUCOPYRANOSYL) 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[[[1' (1",6" DIDEOXY 2",3",4" TRI O ACETYL BETA DEXTRO GALACTOPYRANOS 1" YL) PROPAN 2"' ONE] 6" YL] 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; 1,3 BIS [[[[1' (1",6" DIDEOXY BETA DEXTRO GLUCOPYRANOS 1" YL)PROPAN 2"'ONE] 6" YL] 1'H 1',2',3' TRIAZOL 4' YL]METHYL]PYRIMIDINE 2,4(1H,3H)DIONE; ACARBOSE; ALPHA GLUCOSIDASE; ALPHA GLUCOSIDASE INHIBITOR; ANTIDIABETIC AGENT; CARBOHYDRATE; PYRIMIDINE DERIVATIVE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY;

EID: 84907978671     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2014.09.078     Document Type: Article

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