Nucleosides and oligonucleotides containing 1,2,3-triazole residues with nucleobase tethers: Synthesis via the azide-alkyne 'click' reaction

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 18, 2008, Pages 8427-8439

  Chittepu, Padmaja ^a,b   Sirivolu, Venkata Ramana ^a,b   Seela, Frank ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF OSNABRÜCK   (Germany)

Author keywords

1,2,3 Triazole nucleosides; Base pairing; Fluorescence; Huisgen Meldal Sharpless cycloaddition; Oligonucleotides; Propargylated nucleobases

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ADENINE; ALKYNE; AZIDE; COUMARIN; NUCLEOSIDE DERIVATIVE; OLIGONUCLEOTIDE; URACIL;

ARTICLE; BASE MISPAIRING; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE; MOLECULAR MODEL; MOLECULAR STABILITY; REACTION ANALYSIS; SOLID PHASE SYNTHESIS;

ALKYNES; AZIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA; FLUORESCENT DYES; MODELS, CHEMICAL; NUCLEIC ACID CONFORMATION; NUCLEOSIDES; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; TRIAZOLES;

RNA VIRUSES;

EID: 51449095749     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.026     Document Type: Article

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