-
1
-
-
22344452893
-
The natural history of nonalcoholic fatty liver disease: A population-based cohort study
-
Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, et al. (2005) The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 129: 113-121.
-
(2005)
Gastroenterology
, vol.129
, pp. 113-121
-
-
Adams, L.A.1
Lymp, J.F.2
St Sauver, J.3
Sanderson, S.O.4
Lindor, K.D.5
-
2
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
Malhi H, Gores GJ (2008) Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Seminars in liver disease 28: 360-369.
-
(2008)
Seminars in Liver Disease
, vol.28
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
3
-
-
0042165989
-
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
-
Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, et al. (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125: 437-443.
-
(2003)
Gastroenterology
, vol.125
, pp. 437-443
-
-
Feldstein, A.E.1
Canbay, A.2
Angulo, P.3
Taniai, M.4
Burgart, L.J.5
-
4
-
-
0034755341
-
Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
-
Nehra V, Angulo P, Buchman AL, Lindor KD (2001) Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 46: 2347-2352.
-
(2001)
Dig Dis Sci
, vol.46
, pp. 2347-2352
-
-
Nehra, V.1
Angulo, P.2
Buchman, A.L.3
Lindor, K.D.4
-
5
-
-
0037203345
-
Lipoapoptosis: Its mechanism and its diseases
-
Unger RH, Orci L (2002) Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta 1585: 202-212.
-
(2002)
Biochim Biophys Acta
, vol.1585
, pp. 202-212
-
-
Unger, R.H.1
Orci, L.2
-
6
-
-
77955902024
-
The widespread regulation of microRNA biogenesis, function and decay
-
Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of microRNA biogenesis, function and decay. Nature reviews Genetics 11: 597-610.
-
(2010)
Nature Reviews Genetics
, vol.11
, pp. 597-610
-
-
Krol, J.1
Loedige, I.2
Filipowicz, W.3
-
7
-
-
79551592245
-
Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease
-
Alisi A, Da Sacco L, Bruscalupi G, Piemonte F, Panera N, et al. (2011) Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. Laboratory investigation; a journal of technical methods and pathology 91: 283-293.
-
(2011)
Laboratory Investigation; a Journal of Technical Methods and Pathology
, vol.91
, pp. 283-293
-
-
Alisi, A.1
Da Sacco, L.2
Bruscalupi, G.3
Piemonte, F.4
Panera, N.5
-
8
-
-
58149386462
-
Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression
-
Cheung O, Puri P, Eicken C, Contos MJ, Mirshahi F, et al. (2008) Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. Hepatology 48: 1810-1820.
-
(2008)
Hepatology
, vol.48
, pp. 1810-1820
-
-
Cheung, O.1
Puri, P.2
Eicken, C.3
Contos, M.J.4
Mirshahi, F.5
-
9
-
-
79960685445
-
A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA
-
Cazanave SC, Mott JL, Elmi NA, Bronk SF, Masuoka HC, et al. (2011) A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA. Journal of lipid research 52: 1517-1525.
-
(2011)
Journal of Lipid Research
, vol.52
, pp. 1517-1525
-
-
Cazanave, S.C.1
Mott, J.L.2
Elmi, N.A.3
Bronk, S.F.4
Masuoka, H.C.5
-
10
-
-
77954370584
-
CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
-
Cazanave SC, Elmi NA, Akazawa Y, Bronk SF, Mott JL, et al. (2010) CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis. American journal of physiology Gastrointestinal and liver physiology 299: G236-243.
-
(2010)
American Journal of Physiology Gastrointestinal and Liver Physiology
, vol.299
, pp. G236-G243
-
-
Cazanave, S.C.1
Elmi, N.A.2
Akazawa, Y.3
Bronk, S.F.4
Mott, J.L.5
-
11
-
-
33845575826
-
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
-
Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, et al. (2006) Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. Journal of lipid research 47: 2726-2737.
-
(2006)
Journal of Lipid Research
, vol.47
, pp. 2726-2737
-
-
Borradaile, N.M.1
Han, X.2
Harp, J.D.3
Gale, S.E.4
Ory, D.S.5
-
13
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
-
Cunha DA, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, et al. (2008) Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. Journal of cell science 121: 2308-2318.
-
(2008)
Journal of Cell Science
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
Bazarra-Castro, A.4
Ortis, F.5
-
14
-
-
8944259440
-
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
-
Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, et al. (1996) Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Molecular and cellular biology 16: 4273-4280.
-
(1996)
Molecular and Cellular Biology
, vol.16
, pp. 4273-4280
-
-
Wang, X.Z.1
Lawson, B.2
Brewer, J.W.3
Zinszner, H.4
Sanjay, A.5
-
15
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, et al. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes & development 12: 982-995.
-
(1998)
Genes & Development
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
-
16
-
-
84877578475
-
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
-
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, et al. (2013) ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature cell biology 15: 481-490.
-
(2013)
Nature Cell Biology
, vol.15
, pp. 481-490
-
-
Han, J.1
Back, S.H.2
Hur, J.3
Lin, Y.H.4
Gildersleeve, R.5
-
17
-
-
84903749341
-
Cell death. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
-
Lu M, Lawrence DA, Marsters S, Acosta-Alvear D, Kimmig P, et al. (2014) Cell death. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 345: 98-101.
-
(2014)
Science
, vol.345
, pp. 98-101
-
-
Lu, M.1
Lawrence, D.A.2
Marsters, S.3
Acosta-Alvear, D.4
Kimmig, P.5
-
18
-
-
84906569010
-
Bcl-xL Protein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation
-
Gaudette BT, Iwakoshi NN, Boise LH (2014) Bcl-xL Protein Protects from C/EBP Homologous Protein (CHOP)-dependent Apoptosis during Plasma Cell Differentiation. The Journal of biological chemistry 289: 23629-23640.
-
(2014)
The Journal of Biological Chemistry
, vol.289
, pp. 23629-23640
-
-
Gaudette, B.T.1
Iwakoshi, N.N.2
Boise, L.H.3
-
19
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, et al. (2007) ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129: 1337-1349.
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
-
20
-
-
84868525253
-
IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
-
Upton JP, Wang L, Han D, Wang ES, Huskey NE, et al. (2012) IRE1alpha cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science 338: 818-822.
-
(2012)
Science
, vol.338
, pp. 818-822
-
-
Upton, J.P.1
Wang, L.2
Han, D.3
Wang, E.S.4
Huskey, N.E.5
-
21
-
-
79953794116
-
The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis
-
Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, et al. (2011) The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. The EMBO journal 30: 1357-1375.
-
(2011)
The EMBO Journal
, vol.30
, pp. 1357-1375
-
-
Zhang, K.1
Wang, S.2
Malhotra, J.3
Hassler, J.R.4
Back, S.H.5
-
22
-
-
0027227827
-
Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
-
Spivey JR, Bronk SF, Gores GJ (1993) Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. The Journal of clinical investigation 92: 17-24.
-
(1993)
The Journal of Clinical Investigation
, vol.92
, pp. 17-24
-
-
Spivey, J.R.1
Bronk, S.F.2
Gores, G.J.3
-
23
-
-
34547193134
-
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
-
Malhi H, Barreyro FJ, Isomoto H, Bronk SF, Gores GJ (2007) Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity. Gut 56: 1124-1131.
-
(2007)
Gut
, vol.56
, pp. 1124-1131
-
-
Malhi, H.1
Barreyro, F.J.2
Isomoto, H.3
Bronk, S.F.4
Gores, G.J.5
-
25
-
-
80255127234
-
Cutadapt removes adapter sequences from high-throughput sequencing reads
-
Martin M (2011) Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnetjournal 17.
-
(2011)
EMBnetjournal
, vol.17
-
-
Martin, M.1
-
26
-
-
62349130698
-
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
-
Langmead B, Trapnell C, Pop M, Salzberg SL (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome biology 10: R25.
-
(2009)
Genome Biology
, vol.10
, pp. R25
-
-
Langmead, B.1
Trapnell, C.2
Pop, M.3
Salzberg, S.L.4
-
27
-
-
41849084855
-
Discovering microRNAs from deep sequencing data using miRDeep
-
Friedlander MR, Chen W, Adamidi C, Maaskola J, Einspanier R, et al. (2008) Discovering microRNAs from deep sequencing data using miRDeep. Nature biotechnology 26: 407-415.
-
(2008)
Nature Biotechnology
, vol.26
, pp. 407-415
-
-
Friedlander, M.R.1
Chen, W.2
Adamidi, C.3
Maaskola, J.4
Einspanier, R.5
-
28
-
-
75249087100
-
edgeR: A Bioconductor package for differential expression analysis of digital gene expression data
-
Robinson MD, McCarthy DJ, Smyth GK (2010) edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26: 139-140.
-
(2010)
Bioinformatics
, vol.26
, pp. 139-140
-
-
Robinson, M.D.1
McCarthy, D.J.2
Smyth, G.K.3
-
29
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
-
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
30
-
-
80055026523
-
Fast food diet mouse: Novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
-
Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, et al. (2011) Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. American journal of physiology Gastrointestinal and liver physiology 301: G825-834.
-
(2011)
American Journal of Physiology Gastrointestinal and Liver Physiology
, vol.301
, pp. G825-G834
-
-
Charlton, M.1
Krishnan, A.2
Viker, K.3
Sanderson, S.4
Cazanave, S.5
-
31
-
-
4644237189
-
Fast and effective prediction of microRNA/target duplexes
-
Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R (2004) Fast and effective prediction of microRNA/target duplexes. RNA 10: 1507-1517.
-
(2004)
RNA
, vol.10
, pp. 1507-1517
-
-
Rehmsmeier, M.1
Steffen, P.2
Hochsmann, M.3
Giegerich, R.4
-
32
-
-
77950821179
-
Linking endoplasmic reticulum stress to cell death in hepatocytes: Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
-
Pfaffenbach KT, Gentile CL, Nivala AM, Wang D, Wei Y, et al. (2010) Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. American journal of physiology Endocrinology and metabolism 298: E1027-1035.
-
(2010)
American Journal of Physiology Endocrinology and Metabolism
, vol.298
, pp. E1027-E1035
-
-
Pfaffenbach, K.T.1
Gentile, C.L.2
Nivala, A.M.3
Wang, D.4
Wei, Y.5
-
33
-
-
84879568119
-
C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis
-
Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, et al. (2013) C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. The Journal of biological chemistry 288: 18624-18642.
-
(2013)
The Journal of Biological Chemistry
, vol.288
, pp. 18624-18642
-
-
Malhi, H.1
Kropp, E.M.2
Clavo, V.F.3
Kobrossi, C.R.4
Han, J.5
-
35
-
-
84869087503
-
miR-211 is a prosurvival microRNA that regulates chop expression in a PERKdependent manner
-
Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, et al. (2012) miR-211 is a prosurvival microRNA that regulates chop expression in a PERKdependent manner. Molecular cell 48: 353-364.
-
(2012)
Molecular Cell
, vol.48
, pp. 353-364
-
-
Chitnis, N.S.1
Pytel, D.2
Bobrovnikova-Marjon, E.3
Pant, D.4
Zheng, H.5
-
36
-
-
84863484585
-
Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis
-
Gupta S, Read DE, Deepti A, Cawley K, Gupta A, et al. (2012) Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis. Cell death & disease 3: e333.
-
(2012)
Cell Death & Disease
, vol.3
, pp. e333
-
-
Gupta, S.1
Read, D.E.2
Deepti, A.3
Cawley, K.4
Gupta, A.5
-
37
-
-
69149087790
-
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
-
Barres R, Osler ME, Yan J, Rune A, Fritz T, et al. (2009) Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell metabolism 10: 189-198.
-
(2009)
Cell Metabolism
, vol.10
, pp. 189-198
-
-
Barres, R.1
Osler, M.E.2
Yan, J.3
Rune, A.4
Fritz, T.5
|