Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels

Cell Metabolism

Volumn 20, Issue 4, 2014, Pages 650-661

  Srivastava, Nishi ^a   Kollipara, Rahul K ^a   Singh, Dinesh K ^a,c   Sudderth, Jessica ^a   Hu, Zeping ^a   Nguyen, Hien ^a,d   Wang, Shan ^a   Humphries, Caroline G ^a   Carstens, Ryan ^a   Huffman, Kenneth E ^a   Deberardinis, Ralph J ^a,b   Kittler, Ralf ^a,b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; GLUTATHIONE; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PYRUVATE DEHYDROGENASE KINASE 4; REACTIVE OXYGEN METABOLITE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC AGENT; PROTEIN KINASE; RETINOBLASTOMA PROTEIN; TRIMETAZIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FATTY ACID OXIDATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; RETINOBLASTOMA; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE CHECKPOINT; CHEMISTRY; DRUG EFFECTS; HUMAN; LIPID PEROXIDATION; METABOLISM; NEOPLASMS; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SCID MOUSE; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; FATTY ACIDS; HUMANS; LIPID PEROXIDATION; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASMS; PHOSPHORYLATION; PPAR GAMMA; PROTEIN INTERACTION MAPS; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RETINOBLASTOMA PROTEIN; THIAZOLIDINEDIONES; TRANSPLANTATION, HETEROLOGOUS; TRIMETAZIDINE;

EID: 84907977011     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.08.003     Document Type: Article

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