Redox Signaling via Oxidative Inactivation of PTEN Modulates Pressure-Dependent Myogenic Tone in Rat Middle Cerebral Arteries

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Gebremedhin, Debebe ^a   Terashvili, Maia ^a   Wickramasekera, Nadi ^a   Zhang, David X ^a   Rau, Nicole ^a   Miura, Hiroto ^a   Harder, David R ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; HYDROGEN PEROXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POTASSIUM CHANNEL; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL CELL; ARTERY CONSTRICTION; ARTICLE; BLOOD PRESSURE; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HEART MUSCLE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MICROSCOPY; MIDDLE CEREBRAL ARTERY; MOLECULAR INTERACTION; MUSCLE TONE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PATCH CLAMP; POTASSIUM CURRENT; RAT; SIGNAL TRANSDUCTION; ULTRAVIOLET SPECTROSCOPY; WESTERN BLOTTING;

ANIMALS; CALCIUM; CATALASE; ENZYME ACTIVATION; HYDROGEN PEROXIDE; MALE; MIDDLE CEREBRAL ARTERY; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; OXIDATION-REDUCTION; OXIDATIVE STRESS; POLYETHYLENE GLYCOLS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PRESSURE; PTEN PHOSPHOHYDROLASE; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDES;

RATTUS; VASCONCELLEA CANDICANS;

EID: 84879802004     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068498     Document Type: Article

References (36)

1. Bayliss WM, (1902) On the local reactions of the arterial wall to changes of internal pressure. J Physiol Lond 28: 220-231.
2. Folkow B, (1964) Description of the myogenic hypothesis. Circ Res (Suppl. 1): pp. 1279-1287.
3. Ungvari Z, Csiszar A, Edwards JG, Kaminski PM, Wolin MS, et al. (2003) Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler Thromb Vasc Biol 23: 418-424.
4. Lehoux S, (2006) Redox signalling in vascular responses to shear and stretch. Cardiovasc Res 71(2): 269-79.
5. Huang A, Sun D, Kaley G, Koller A, (1998) Superoxide released to high intra-arteriolar pressure reduces nitric oxide-mediated shear stress- and agonist-induced dilations. Circ Res 83(9): 960-5.
6. Harder DR, (1984) Pressure-dependent membrane depolarization in cat middle cerebral artery. Circ Res 55: 197-202.
7. Sokoloff L (1989) Circulation and energy metabolism of the brain. In: Siegel G, Agranoff B, Albers RW, Molinoff P, editors. Basic neurochemistry 4th Ed (Raven Press). 565-590.
8. Siesjo BK, (1992a) Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 77(2): 169-184.
9. Siesjo BK, (1992b) Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment. J Neurosurg 77(3): 337-354.
10. Doppenberg EM, (1998) Correlations between brain tissue oxygen tension, carbon dioxide tension, pH, and cerebral blood flow - a better way of monitoring the severely injured brain? Surg Neurol 49(6): 650-654.
11. Oudit GY, Penninger JM, (2009) Cardiac regulation by phosphoinositide 3-kinases and PTEN.Cardiovasc Res. 82: 250-260.
12. Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, et al. (2012) PI3Kg inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism. Cardiovasc Res 93: 200-209.
13. Maehama T, Dixon JE, (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
14. Maehama T, Taylor GS, Dixon JE, (2001) PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem 70: 247-279.
15. Gebremedhin D, Yamaura K, Harder DR, (2008) Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol 294: H107-120.
16. Gebremedhin D, Weinberg B, Lourim D, Harder DR, (2010) Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb. Blood Flow Metab 30(10): 1777-90.
17. Zielonka J, Zielonka M, Sikora A, Adamus J, Joseph J, et al. (2012) Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. J Biol Chem 287(5): 2984-95.
18. Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, et al. (2003) Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Rad Biol Med 34(11): 1359-1368.
19. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ, (1981) Improved patch-clamp technique for high resolution current recording from cells and cell-free membrane patches. Eur J Physiol 391: 85-100.
20. D, Yamaura K, Zhang C, Bylund J, Koehler RC, Harder DR, (2003) Activation of metabotropic glutamate receptors enhance the activities of two types of Ca2+-activated K+ channel currents in rat hipocampal astrocytes. J Neurosci 23(5): 1678-1687.
21. Duong HQ, Kim HJ, Kang HJ, Seong YS, Bae I, (2012) ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine. Oncol Rep 27(1): 182-8.
22. Kong DX, Yamori T, (2010) ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system. Acta Pharmacol Sin 31(9): 1189-97.
23. Anzai K, Sekine-Suzuki E, Ueno M, Okamura M, Yoshimi H, et al. (2011) Effectiveness of combined treatment using X-rays and a phosphoinositide 3-kinase inhibitor, ZSTK474, on proliferation of HeLa cells in vitro and in vivo. Cancer Sci 102(6): 1176-80.
24. Schmid AC, Byrne RD, Vilar R, Woscholski R, (2004) Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Letters 566 (1-3): 35-38.
25. Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, et al. (2010) TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol 298 (2): H466-76.
26. Zagorac D, Yamaura K, Zhang C, Roman RJ, Harder DR, (2005) The effect of superoxide anion on autoregulation of cerebral blood flow. Stroke 36(12): 2589-94.
27. Lee SR, Yang KS, Kwon J, Lee C, Jeong W, Rhee SG, (2002) Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 277: 20336-20342.
28. Myers MP, Stolarov JP, Eng C, Li J, Wang SI, et al. (1997) PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 94: 9052-9057.
29. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, et al. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95: 29-39.
30. Phillips SA, Olson EB, Lombard JH, Morgan BJ, (2006) Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries. J Appl Physiol 100(4): 1117-23.
31. Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, et al. (2004) The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 37(2): 449-71.
32. Sokoloff L (1989) Circulation and energy metabolism of the brain. In: Siegel G, Agranoff B, Albers RW, Molinoff P, editors. Basic neurochemistry 4th ed (Raven Press). 565-590.
33. Siesjo BK, (1992a) Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 77(2): 169-184.
34. Siesjo BK, (1992b) Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment. J Neurosurg 77(3): 337-354.
35. Liu B, Gan L, Sun X, Zhu Y, Tong Z, et al. (2009) Enhancement of BKCa channel activity induced by hydrogen peroxide: Involvement of lipid phosphatase activity of PTEN. Biochim Biophys Acta 1788: 2174-2182.
36. Wan X, Dannis AT, Obejero-Paz C, Overholt JL, Heredia-Moya J, et al. (2011) Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome. J Biol Chem 286 (4): 2843-52.