Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response

Journal of Virology

Volumn 84, Issue 24, 2010, Pages 12761-12770

  Steidle, Sabine ^a   Martínez Sobrido, Luis ^b   Mordstein, Markus ^a   Lienenklaus, Stefan ^c   García Sastre, Adolfo ^d   Stäheli, Peter ^a   Kochs, Georg ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; GLYCINE; INTERFERON; NONSTRUCTURAL PROTEIN 1;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE RESPONSE; EMBRYO; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; VIRUS MUTANT; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; GLYCINE; IMMUNOPRECIPITATION; INFLUENZA A VIRUS; INTERFERONS; LUCIFERASES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; RNA, VIRAL; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE; VIRUS REPLICATION;

INFLUENZA A VIRUS; MUS;

EID: 78649414629     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00701-10     Document Type: Article

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