Wogonin attenuates endotoxin-induced prostaglandin E2 and nitric oxide production via Src-ERK1/2-NFκB pathway in BV-2 microglial cells

Environmental Toxicology

Volumn 29, Issue 10, 2014, Pages 1162-1170

  Yeh, Chung Hsin ^a   Yang, Ming Ling ^b   Lee, Chien Ying ^b,c   Yang, Ching Ping ^d   Li, Yi Ching ^b   Chen, Chun Jung ^e   Kuan, Yu Hsiang ^b,c  

^a SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

MEK1 2 ERK1 2; Microglia; NF B; Src; Wogonin

Indexed keywords

CELLS; MOLECULAR INTERACTIONS; NITRIC OXIDE;

ANTI-INFLAMMATORY FUNCTION; CONCENTRATION RANGES; CONCENTRATION-DEPENDENT MANNERS; MEK1/2-ERK1/2; MICROGLIA; MOLECULAR MECHANISM; PROTECTIVE EFFECTS; WOGONIN;

CYTOLOGY;

ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN TYROSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; WOGONIN; ANTIINFLAMMATORY AGENT; FLAVANONE DERIVATIVE; HERBACEOUS AGENT; LIPOPOLYSACCHARIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BV 2 CELL; CELL ACTIVATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; MICROGLIA; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; MEK1/2-ERK1/2; MOUSE; NFΚB; SRC;

MEK1/2-ERK1/2; MICROGLIA; NFΚB; SRC; WOGONIN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; DINOPROSTONE; DRUGS, CHINESE HERBAL; FLAVANONES; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84907864070     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21847     Document Type: Article

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