Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin

Journal of Ethnopharmacology

Volumn 137, Issue 3, 2011, Pages 1373-1380

  Dong, Ping ^a   Zhang, Yong ^a   Gu, Jun ^a   Wu, Wenguang ^b   Li, Maolan ^a   Yang, Jiahua ^a   Zhang, Lin ^a   Lu, Jianhua ^a   Mu, Jiasheng ^a   Chen, Lei ^a   Li, Songgang ^a   Wang, Jianwei ^b   Liu, Yingbin ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Human gallbladder carcinoma; Maspin; Metastasis; Scutellaria baicalensis; Wogonin

Indexed keywords

ANTIMETASTATIC AGENT; GELATINASE A; GELATINASE B; LIPOCORTIN 5; MASPIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SCUTELLARIA BAICALENSIS EXTRACT; SMALL INTERFERING RNA; WOGONIN;

APOPTOSIS; ARTICLE; CANCER INVASION; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL VIABILITY; CHEMOPROPHYLAXIS; CHINESE HERB; CONTROLLED STUDY; GALLBLADDER CARCINOMA; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKEMIA; METASTASIS INHIBITION; PROSTATE CARCINOMA; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; GALLBLADDER NEOPLASMS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PLANT EXTRACTS; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SCUTELLARIA BAICALENSIS; SERPINS; TIME FACTORS; UP-REGULATION;

SCUTELLARIA BAICALENSIS;

EID: 80054952939     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.08.005     Document Type: Article

References (32)

1. C.M. Bailey, Z. Khalkhali-Ellis, E.A. Seftor, and M.J. Hendrix Biological functions of maspin Journal of Cell Physiology 209 2006 617 624
2. S. Baumann, S.C. Fas, M. Giaisi, W.W. Muller, A. Merling, K. Gulow, L. Edler, P.H. Krammer, and M. Li-Weber Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis Blood 111 2008 2354 2363
3. A.B. Beshir, G. Ren, A.N. Magpusao, L.M. Barone, K.C. Yeung, and G. Fenteany Raf kinase inhibitor protein suppresses nuclear factor-kappaB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression Cancer Letter 299 2010 137 149
4. Y.S. Chi, B.S. Cheon, and H.P. Kim Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells Biochemical Pharmacology 61 2001 1195 1203
5. Z. Gao, K. Huang, X. Yang, and H. Xu Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi Biochimica et Biophysica Acta 1472 1999 643 650
6. Q. Guo, L. Zhao, Q. You, Y. Yang, H. Gu, G. Song, N. Lu, and J. Xin Anti-hepatitis B virus activity of wogonin in vitro and in vivo Antiviral Research 74 2007 16 24
7. S.N. Hong, J.K. Lee, W.H. Choe, H.Y. Ha, K. Park, I.K. Sung, K.T. Lee, J.J. Kim, and J.C. Rhee The effect of aberrant maspin expression on the invasive ability of pancreatic ductal adenocarcinoma cells Oncology Reports 21 2009 425 430
8. K.M. Hui, M.S. Huen, H.Y. Wang, H. Zheng, E. Sigel, R. Baur, H. Ren, Z.W. Li, J.T. Wong, and H. Xue Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi Biochemical Pharmacology 64 2002 1415 1424
9. N. Jiang, Y. Meng, S. Zhang, E. Mensah-Osman, and S. Sheng Maspin sensitizes breast carcinoma cells to induced apoptosis Oncogene 21 2002 4089 4098
10. Z. Khalkhali-Ellis Maspin: the new frontier Clinical Cancer Research 12 2006 7279 7283
11. C.A. Klein Cancer. The metastasis cascade Science 321 2008 1785 1787
12. T. Kumagai, C.I. Muller, J.C. Desmond, Y. Imai, D. Heber, and H.P. Koeffler Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines Leukemia Research 31 2007 523 530
13. H. Lee, Y.O. Kim, H. Kim, S.Y. Kim, H.S. Noh, S.S. Kang, G.J. Cho, W.S. Choi, and K. Suk Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia The FASEB Journal 17 2003 1943 1944
14. S.O. Lee, Y.J. Jeong, M.H. Yu, J.W. Lee, M.H. Hwangbo, C.H. Kim, and I.S. Lee Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells Biochemical and Biophysical Research Communications 351 2006 118 125
15. D.H. Lee, C. Kim, L. Zhang, and Y.J. Lee Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells Biochemical Pharmacology 75 2008 2020 2033
16. D.C. Lev, A. Onn, V.O. Melinkova, C. Miller, V. Stone, M. Ruiz, E.C. McGary, H.N. Ananthaswamy, J.E. Price, and M. Bar-Eli Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo Journal of Clinical Oncology 22 2004 2092 2100
17. J.S. Lim, M. Yoo, H.J. Kwon, H. Kim, and Y.K. Kwon Wogonin induces differentiation and neurite outgrowth of neural precursor cells Biochemical and Biophysical Research Communications 402 2010 42 47
18. M. Li-Weber New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin Cancer Treatment Reviews 35 2009 57 68
19. J. Lockett, S. Yin, X. Li, Y. Meng, and S. Sheng Tumor suppressive maspin and epithelial homeostasis Journal of Cellular Biochemistry 97 2006 651 660
20. F. Lonardo, X. Li, A. Kaplun, A. Soubani, S. Sethi, S. Gadgeel, and S. Sheng The natural tumor suppressor protein maspin and potential application in non small cell lung cancer Current Pharmaceutical Design 16 2010 1877 1881
21. N. Lu, Y. Gao, Y. Ling, Y. Chen, Y. Yang, H.Y. Gu, Q. Qi, W. Liu, X.T. Wang, Q.D. You, and Q.L. Guo Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2 Life Sciences 82 2008 956 963
22. S. Nozaki, S. Sissons, D.S. Chien, and G.W. Sledge Jr. Activity of biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in a human breast cancer orthotopic model Clinical and Experimental Metastasis 20 2003 407 412
23. H.G. Park, S.Y. Yoon, J.Y. Choi, G.S. Lee, J.H. Choi, C.Y. Shin, K.H. Son, Y.S. Lee, W.K. Kim, and J.H. Ryu Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis The European Journal of Pharmacology 574 2007 112 119
24. Z. Quan, J. Gu, P. Dong, J. Lu, X. Wu, W. Wu, X. Fei, S. Li, Y. Wang, and J. Wang Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to cirsimaritin-induced apoptosis in human gallbladder carcinoma GBC-SD cells Cancer Letter 295 2010 252 259
25. X. Shang, X. He, M. Li, R. Zhang, P. Fan, Q. Zhang, and Z. Jia The genus Scutellaria an ethnopharmacological and phytochemical review The Journal of Ethnopharmacology 128 2010 279 313
26. H.Y. Shi, W. Zhang, R. Liang, S. Abraham, F.S. Kittrell, D. Medina, and M. Zhang Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model Cancer Research 61 2001 6945 6951
27. W. Wang, Q.L. Guo, Q.D. You, K. Zhang, Y. Yang, J. Yu, W. Liu, L. Zhao, H.Y. Gu, and Y. Hu The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo Biological and Pharmaceutical Bulletin 29 2006 1132 1137
28. J.W. Wang, S.Y. Peng, J.T. Li, Y. Wang, Z.P. Zhang, Y. Cheng, D.Q. Cheng, W.H. Weng, X.S. Wu, and X.Z. Fei Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1 Cancer Letter 281 2009 71 81
29. F. Ye, L. Xui, J. Yi, W. Zhang, and D.Y. Zhang Anticancer activity of Scutellaria baicalensis and its potential mechanism The Journal of Alternative and Complementary Medicine 8 2002 567 572
30. S.Y. Yeom, H.L. Jang, S.J. Lee, E. Kim, H.J. Son, B.G. Kim, and C. Park Interaction of testisin with maspin and its impact on invasion and cell death resistance of cervical cancer cells FEBS Letters 584 2010 1469 1475
31. H.W. Zhang, Y. Yang, K. Zhang, L. Qiang, L. Yang, Y. Hu, X.T. Wang, Q.D. You, and Q.L. Guo Wogonin induced differentiation and G1 phase arrest of human U-937 leukemia cells via PKCdelta phosphorylation European Journal of Pharmacology 591 2008 7 12
32. Z. Zou, A. Anisowicz, M.J. Hendrix, A. Thor, M. Neveu, S. Sheng, K. Rafidi, E. Seftor, and R. Sager Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells Science 263 1994 526 529