A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Suzuki, Teruhiko ^a   Kazuki, Yasuhiro ^b   Oshimura, Mitsuo ^b   Hara, Takahiko ^a,c  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; ENHANCED GREEN FLUORESCENT PROTEIN; INTEGRASE; RECOMBINASE;

ANIMAL CELL; ARTICLE; CHO CELL LINE; CONTROLLED STUDY; DNA RECOMBINATION; EGFP GENE; GENE CASSETTE; GENE DELIVERY SYSTEM; GENE INSERTION; GENE LOADING VECTOR; GENE TRANSFER; GENE VECTOR; GENETIC PROCEDURES; HUMAN ARTIFICIAL CHROMOSOME; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TDTOMATO GENE; VENUS GENE; ANIMAL; CELL LINE; GENE EXPRESSION; GENE ORDER; HOMOLOGOUS RECOMBINATION; HUMAN; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REPORTER GENE; SEQUENCE ALIGNMENT; TRANSGENE;

ANIMALS; BASE SEQUENCE; CELL LINE; CHROMOSOMES, ARTIFICIAL, HUMAN; GENE EXPRESSION; GENE ORDER; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; HOMOLOGOUS RECOMBINATION; HUMANS; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; TRANSGENES;

EID: 84907817055     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110404     Document Type: Article

References (30)

1. Kuroiwa Y, Tomizuka K, Shinohara T, Kazuki Y, Yoshida H, et al. (2000) Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts. Nat Biotechnol 18: 1086-1090.
2. Hoshiya H, Kazuki Y, Abe S, Takiguchi M, Kajitani N, et al. (2009) A highly stable and nonintegrated human artificial chromosome (HAC) containing the 2.4 Mb entire human dystrophin gene. Mol Ther 17: 309-317.
3. Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, et al. (2010) Complete genetic correction of ips cells from Duchenne muscular dystrophy. Mol Ther 18: 386-393.
4. Tomizuka K, Yoshida H, Uejima H, Kugoh H, Sato K, et al. (1997) Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nat Genet 16: 133-143.
5. Kuroiwa Y, Kasinathan P, Choi YJ, Naeem R, Tomizuka K, et al. (2002) Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol 20: 889-894.
6. Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, et al. (2011) Integrationfree iPS cells engineered using human artificial chromosome vectors. PLoS One 6: e25961.
7. Kakeda M, Nagata K, Osawa K, Matsuno H, Hiratsuka M, et al. (2011) A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells. Biochem Biophys Res Commun 415: 439-444.
8. Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, et al. (2010) Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res 17: 293-301.
9. Nakano M, Cardinale S, Noskov VN, Gassmann R, Vagnarelli P, et al. (2008) Inactivation of a human kinetochore by specific targeting of chromatin modifiers. Dev Cell 14: 507-522.
10. Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, et al. (2011) Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A 108: 20048-20053.
11. Iida Y, Kazuki Y, Hayashi M, Ueda Y, Hasegawa M, et al. (2014) Bi-HAC vector system toward gene and cell therapy. ACS Synth Biol 3: 83-90.
12. Du Y, Wang J, Jia J, Song N, Xiang C, et al. (2014) Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell 14: 394-403.
13. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, et al. (2011) Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 9: 205-218.
14. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, et al. (2014) Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell 157: 549-564.
15. Tóth A, Fodor K, Praznovszky T, Tubak V, Udvardy A, et al. (2014) Novel method to load multiple genes onto a mammalian artificial chromosome. PLoS One 9: e85565.
16. Yamaguchi S, Kazuki Y, Nakayama Y, Nanba E, Oshimura M, et al. (2011) A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector. PLoS One 6: e17267.
17. Voet T, Vermeesch J, Carens A, Dürr J, Labaere C, et al. (2001) Efficient male and female germline transmission of a human chromosomal vector in mice. Genome Res 11: 124-136.
18. Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, et al. (2011) Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Ther 18: 384-393.
19. Takiguchi M, Kazuki Y, Hiramatsu K, Abe S, Iida Y, et al. (2012) A Novel and Stable Mouse Artificial Chromosome Vector. ACS Synth Biol.
20. Kurosaki H, Hiratsuka M, Imaoka N, Iida Y, Uno N, et al. (2011) Integrationfree and stable expression of FVIII using a human artificial chromosome. J Hum Genet 56: 727-733.
21. Branda CS, Dymecki SM (2004) Talking about a revolution: The impact of sitespecific recombinases on genetic analyses in mice. Dev Cell 6: 7-28.
22. Esposito D, Scocca JJ (1997) The integrase family of tyrosine recombinases: evolution of a conserved active site domain. Nucleic Acids Res 25: 3605-3614.
23. Brown WR, Lee NC, Xu Z, Smith MC (2011) Serine recombinases as tools for genome engineering. Methods 53: 372-379.
24. Thyagarajan B, Olivares EC, Hollis RP, Ginsburg DS, Calos MP (2001) Sitespecific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol Cell Biol 21: 3926-3934.
25. Groth AC, Olivares EC, Thyagarajan B, Calos MP (2000) A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A 97: 5995-6000.
26. Kouprina N, Tomilin AN, Masumoto H, Earnshaw WC, Larionov V (2014) Human artificial chromosome-based gene delivery vectors for biomedicine and biotechnology. Expert Opin Drug Deliv 11: 517-535.
27. Miyamoto K, Suzuki N, Sakai K, Asakawa S, Okazaki T, et al. (2014) A novel mouse model for Down syndrome that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21. Transgenic Res 23: 317-329.
28. Robberson BL, Cote GJ, Berget SM (1990) Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol Cell Biol 10: 84-94.
29. Kouprina N, Samoshkin A, Erliandri I, Nakano M, Lee HS, et al. (2012) Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere. ACS Synth Biol 1: 590-601.
30. Kitajima K, Minehata K, Sakimura K, Nakano T, Hara T (2011) In vitro generation of HSC-like cells from murine ESCs/iPSCs by enforced expression of LIM-homeobox transcription factor Lhx2. Blood 117: 3748-3758.