Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice

FASEB Journal

Volumn 28, Issue 10, 2014, Pages 4312-4323

  Yan, Jian ^a   Ginsberg, Stephen D ^b,c   Powers, Brian ^a   Alldred, Melissa J ^b,c   Saltzman, Arthur ^b   Strupp, Barbara J ^a   Caudill, Marie A ^a  

^a Division of Nutritional Sciences Cornell University 228 Savage Hall ^*  (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Docosahexaenoic acid; Down syndrome; Fetal programming; Phosphatidylcholine

Indexed keywords

ACETYLCHOLINE; BETAINE; CHOLINE; CHOLINE DERIVATIVE; CITICOLINE; DOCOSAHEXAENOIC ACID; DRUG METABOLITE; METHYL D9 CHOLINE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE METHYLTRANSFERASE; UNCLASSIFIED DRUG; PEMT PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CEREBELLUM; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISOMY; ENZYME ACTIVITY; FEMALE; FOREBRAIN; GENOTYPE; HIPPOCAMPUS; LIVER; LIVER METABOLISM; NEOCORTEX; NONHUMAN; PERINATAL PERIOD; PLASMA; RAT; TRISOMY; UPREGULATION; ANIMAL; C57BL MOUSE; DOWN SYNDROME; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; MOUSE; PREGNANCY; PRENATAL EXPOSURE; TISSUE DISTRIBUTION;

ANIMALS; CHOLINE; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOWN SYNDROME; FEMALE; LIPID METABOLISM; MICE; MICE, INBRED C57BL; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TISSUE DISTRIBUTION;

EID: 84907709157     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-251736     Document Type: Article

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