Lab-on-a-Chip hyphenation with mass spectrometry: Strategies for bioanalytical applications

Current Opinion in Biotechnology

Volumn 31, Issue , 2015, Pages 79-85

  Oedit, Amar ^a,b   Vulto, Paul ^a,b,c   Ramautar, Rawi ^a,b   Lindenburg, Petrus W ^a,b   Hankemeier, Thomas ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b Netherlands Metabolomics Centre   (Netherlands)

^c Mimetas BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; LAB-ON-A-CHIP; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR BIOLOGY; SPECTROMETRY;

APPLICATION RANGE; BIOANALYTICAL APPLICATIONS; BOTTOM UP APPROACH; DETECTION METHODS; HYPHENATED SYSTEMS; LABORATORY PROCESS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; MICROFLUIDIC CHIP;

DRUG PRODUCTS;

ANIMAL; DEVICES; ELECTRON; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROFLUIDIC ANALYSIS; PROCEDURES;

ANIMALS; CHROMATOGRAPHY, LIQUID; ELECTRONS; HUMANS; MASS SPECTROMETRY; MICROFLUIDIC ANALYTICAL TECHNIQUES;

EID: 84907704977     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2014.08.009     Document Type: Review

References (45)

1. Zhu Y., Fang Q. Analytical detection techniques for droplet microfluidics-a review. Anal Chim Acta 2013, 787:24-35.
2. Xue Q., Foret F., Dunayevskiy Y.M., Zavracky P.M., McGruer N.E., Karger B.L. Multichannel microchip electrospray mass spectrometry. Anal Chem 1997, 69:426-430.
3. Gao D., Liu H., Jiang Y., Lin J.M. Recent advances in microfluidics combined with mass spectrometry: technologies and applications. Lab Chip 2013, 13:3309-3322.
4. Feng X., Liu B.F., Li J., Liu X. Advances in coupling microfluidic chips to mass spectrometry. Mass Spectrom Rev 2014, Advance online publication. 10.1002/mas.21417.
5. Wang S., Chen S., Wang J., Xu P., Luo Y., Nie Z., Du W. Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry. Electrophoresis 2014, 35:2528-2533.
6. Momotenko D., Qiao L., Cortes-Salazar F., Lesch A., Wittstock G., Girault H.H. Electrochemical push-pull scanner with mass spectrometry detection. Anal Chem 2012, 84:6630-6637.
7. Mao P., Gomez-Sjoberg R., Wang D. Multinozzle emitter array chips for small-volume proteomics. Anal Chem 2013, 85:816-819.
8. Kuster S.K., Fagerer S.R., Verboket P.E., Eyer K., Jefimovs K., Zenobi R., Dittrich P.S. Interfacing droplet microfluidics with matrix-assisted laser desorption/ionization mass spectrometry: label-free content analysis of single droplets. Anal Chem 2013, 85:1285-1289.
9. Neu V., Steiner R., Muller S., Fattinger C., Zenobi R. Development and characterization of a capillary gap sampler as new microfluidic device for fast and direct analysis of low sample amounts by ESI-MS. Anal Chem 2013, 85:4628-4635.
10. Aijian A.P., Chatterjee D., Garrell R.L. Fluorinated liquid-enabled protein handling and surfactant-aided crystallization for fully in situ digital microfluidic MALDI-MS analysis. Lab Chip 2012, 12:2552-2559.
11. Sun X., Tang K., Smith R.D., Kelly R.T. Controlled dispensing and mixing of pico- to nanoliter volumes using on-demand droplet-based microfluidics. Microfluid Nanofluid 2013, 15:117-126.
12. Su Y., Zhu Y., Fang Q. A multifunctional microfluidic droplet-array chip for analysis by electrospray ionization mass spectrometry. Lab Chip 2013, 13:1876-1882.
13. Ji J., Nie L., Qiao L., Li Y., Guo L., Liu B., Yang P., Girault H.H. Proteolysis in microfluidic droplets: an approach to interface protein separation and peptide mass spectrometry. Lab Chip 2012, 12:2625-2629.
14. Rob T., Liuni P., Gill P.K., Zhu S., Balachandran N., Berti P.J., Wilson D.J. Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry. Anal Chem 2012, 84:3771-3779.
15. Rob T., Gill P.K., Golemi-Kotra D., Wilson D.J. An electrospray MS-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition. Lab Chip 2013, 13:2528-2532.
16. Shih S.C., Yang H., Jebrail M.J., Fobel R., McIntosh N., Al-Dirbashi O.Y., Chakraborty P., Wheeler A.R. Dried blood spot analysis by digital microfluidics coupled to nanoelectrospray ionization mass spectrometry. Anal Chem 2012, 84:3731-3738.
17. Serb A.F., Sisu E., Vukelic Z., Zamfir A.D. Profiling and sequencing of gangliosides from human caudate nucleus by chip-nanoelectrospray mass spectrometry. J Mass Spectrom 2012, 47:1561-1570.
18. Flangea C., Mosoarca C., Cozma C., Galusca M., Przybylski M., Zamfir A.D. Testing the feasibility of fully automated chip-based nanoelectrospray ionization mass spectrometry as a novel tool for rapid diagnosis of Fabry disease. Electrophoresis 2013, 34:1572-1580.
19. Flangea C., Petrescu A.J., Seidler D.G., Munteanu C.V., Zamfir A.D. Identification of an unusually sulfated tetrasaccharide chondroitin/dermatan motif in mouse brain by combining chip-nanoelectrospray multistage MS2-MS4 and high resolution MS. Electrophoresis 2013, 34:1581-1592.
20. Sainiemi L., Nissila T., Kostiainen R., Franssila S., Ketola R.A. A microfabricated micropillar liquid chromatographic chip monolithically integrated with an electrospray ionization tip. Lab Chip 2012, 12:325-332.
21. Houbart V., Servais A.C., Charlier T.D., Pawluski J.L., Abts F., Fillet M. A validated microfluidics-based LC-chip-MS/MS method for the quantitation of fluoxetine and norfluoxetine in rat serum. Electrophoresis 2012, 33:3370-3379.
22. Ahn G., Park D.M., Park J.W., Cho J.Y., Rhee S.J., Kim H.Y., Lee D.S., Jang I.J., Kim H.K. Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma. Anal Bioanal Chem 2013, 405:9817-9824.
23. Gallagher R., Dillon L., Grimsley A., Murphy J., Samuelsson K., Douce D. The application of a new microfluidic device for the simultaneous identification and quantitation of midazolam metabolites obtained from a single micro-litre of chimeric mice blood. Rapid Commun Mass Spectrom 2014, 28:1293-1302.
24. Liu H.Y., Lin S.L., Chan S.A., Lin T.Y., Fuh M.R. Microfluidic chip-based nano-liquid chromatography tandem mass spectrometry for quantification of aflatoxins in peanut products. Talanta 2013, 113:76-81.
25. Lee H., Lerno L.A., Choe Y., Chu C.S., Gillies L.A., Grimm R., Lebrilla C.B., German J.B. Multiple precursor ion scanning of gangliosides and sulfatides with a reversed-phase microfluidic chip and quadrupole time-of-flight mass spectrometry. Anal Chem 2012, 84:5905-5912.
26. Hua S., Williams C.C., Dimapasoc L.M., Ro G.S., Ozcan S., Miyamoto S., Lebrilla C.B., An H.J., Leiserowitz G.S. Isomer-specific chromatographic profiling yields highly sensitive and specific potential N-glycan biomarkers for epithelial ovarian cancer. J Chromatogr A 2013, 1279:58-67.
27. Franciosi L., Govorukhina N., Fusetti F., Poolman B., Lodewijk M.E., Timens W., Postma D., ten Hacken N., Bischoff R. Proteomic analysis of human epithelial lining fluid by microfluidics-based nanoLC-MS/MS: a feasibility study. Electrophoresis 2013, 34:2683-2694.
28. Prely L.M., Paal K., Hermans J., van der Heide S., van Oosterhout A.J., Bischoff R. Quantification of matrix metalloprotease-9 in bronchoalveolar lavage fluid by selected reaction monitoring with microfluidics nano-liquid-chromatography-mass spectrometry. J Chromatogr A 2012, 1246:103-110.
29. Polat A.N., Kraiczek K., Heck A.J., Raijmakers R., Mohammed S. Fully automated isotopic dimethyl labeling and phosphopeptide enrichment using a microfluidic HPLC phosphochip. Anal Bioanal Chem 2012, 404:2507-2512.
30. Ahonen L., Keski-Rahkonen P., Saarelainen T., Paviala J., Ketola R.A., Auriola S., Poutanen M., Kostiainen R. Comparison of liquid chromatography-microchip/mass spectrometry to conventional liquid chromatography-mass spectrometry for the analysis of steroids. Anal Chim Acta 2012, 721:115-121.
31. Broccardo C.J., Schauer K.L., Kohrt W.M., Schwartz R.S., Murphy J.P., Prenni J.E. Multiplexed analysis of steroid hormones in human serum using novel microflow tile technology and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2013, 934:16-21.
32. Lazar I.M., Kabulski J.L. Microfluidic LC device with orthogonal sample extraction for on-chip MALDI-MS detection. Lab Chip 2013, 13:2055-2065.
33. Zhou H., Castro-Perez J., Lassman M.E., Thomas T., Li W., McLaughlin T., Dan X., Jumes P., Wagner J.A., Gutstein D.E., et al. Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry. Rapid Commun Mass Spectrom 2013, 27:1294-1302.
34. Zhu K.Y., Leung K.W., Ting A.K., Wong Z.C., Ng W.Y., Choi R.C., Dong T.T., Wang T., Lau D.T., Tsim K.W. Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair. Anal Bioanal Chem 2012, 402:2805-2815.
35. Sainiemi L., Sikanen T., Kostiainen R. Integration of fully microfabricated, three-dimensionally sharp electrospray ionization tips with microfluidic glass chips. Anal Chem 2012, 84:8973-8979.
36. Li X., Xiao D., Sanders T., Tchounwou P.B., Liu Y.M. Fast quantification of amino acids by microchip electrophoresis-mass spectrometry. Anal Bioanal Chem 2013, 405:8131-8136.
37. Li X., Zhao S., Liu Y.M. Evaluation of a microchip electrophoresis-mass spectrometry platform deploying a pressure-driven make-up flow. J Chromatogr A 2013, 1285:159-164.
38. Schwarzkopf F., Scholl T., Ohla S., Belder D. Improving sensitivity in microchip electrophoresis coupled to ESI-MS/MS on the example of a cardiac drug mixture. Electrophoresis 2014, 35:1880-1886.
39. Batz N.G., Mellors J.S., Alarie J.P., Ramsey J.M. Chemical vapor deposition of aminopropyl silanes in microfluidic channels for highly efficient microchip capillary electrophoresis-electrospray ionization-mass spectrometry. Anal Chem 2014, 86:3493-3500.
40. Li X., Xiao D., Ou X.M., McCullm C., Liu Y.M. A microchip electrophoresis-mass spectrometric platform for fast separation and identification of enantiomers employing the partial filling technique. J Chromatogr A 2013, 1318:251-256.
41. Mao S., Gao D., Liu W., Wei H., Lin J.M. Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection. Lab Chip 2012, 12:219-226.
42. Chen Q., Wu J., Zhang Y., Lin J.M. Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry. Anal Chem 2012, 84:1695-1701.
43. Gao D., Li H., Wang N., Lin J.M. Evaluation of the absorption of methotrexate on cells and its cytotoxicity assay by using an integrated microfluidic device coupled to a mass spectrometer. Anal Chem 2012, 84:9230-9237.
44. Gao D., Liu H., Lin J.M., Wang Y., Jiang Y. Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device. Lab Chip 2013, 13:978-985.
45. Mao S., Zhang J., Li H., Lin J.M. Strategy for signaling molecule detection by using an integrated microfluidic device coupled with mass spectrometry to study cell-to-cell communication. Anal Chem 2013, 85:868-876.