Development and validation of a microfluidic chip-based nano-liquid chromatography-triple quadrupole tandem mass spectrometry method for a sensitive and reliable quantification of 7-ethyl-10-hydroxycamptothecin (SN38) in mouse plasma

Analytical and Bioanalytical Chemistry

Volumn 405, Issue 30, 2013, Pages 9817-9824

  Ahn, Gang ^a   Park, Dong Min ^a   Park, Jun Won ^a   Cho, Joo Youn ^b   Rhee, Su Jin ^b   Kim, Hyo Young ^c   Lee, Dae Seung ^c   Jang, In Jin ^b   Kim, Hark Kyun ^a  

^a National Cancer Center   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Agilent Technologies Korea Ltd   (South Korea)

Author keywords

Bioanalytical method validation; HPLC chip; Microfluidic chip; Nano liquid chromatography triple quadrupole mass spectrometer; Pharmacokinetic evaluation

Indexed keywords

BIOANALYTICAL METHODS; HPLC CHIP; MICROFLUIDIC CHIP; PHARMACOKINETIC EVALUATION; QUADRUPOLE MASS SPECTROMETER;

DRUG PRODUCTS; FLUIDIC DEVICES; LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS;

CALIBRATION;

CAMPTOTHECIN; DRUG DERIVATIVE; IRINOTECAN;

ANIMAL; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIQUID CHROMATOGRAPHY; MALE; METHODOLOGY; MICROFLUIDICS; MOUSE; NANOTECHNOLOGY; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANIMALS; CAMPTOTHECIN; CHROMATOGRAPHY, LIQUID; MALE; MICE; MICE, INBRED ICR; MICROFLUIDICS; NANOTECHNOLOGY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84890034399     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7411-2     Document Type: Article

References (31)

1. ICH M3(R2) (2009) Guidance on non-clinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals (step 5)
2. Takimoto CH (2009) Phase 0 clinical trials in oncology: a paradigm shift for early drug development? Cancer Chemother Pharmacol 63:703-709
3. Sugiyama Y, Yamashita S (2011) Impact of microdosing clinical study - why necessary and how useful? Adv Drug Deliv Rev 63:494-502
4. Kummar S, Kinders R, Rubinstein L, Parchment RE, Murgo AJ, Collins J et al (2007) Compressing drug development timelines in oncology using phase '0' trials. Nat Rev Cancer 7:131-139
5. Maeda K, Sugiyama Y (2011) Novel strategies for microdose studies using non-radiolabeled compounds. Adv Drug Deliv Rev 63:532-538
6. Meng Z, Veenstra TD (2011) Targeted mass spectrometry approaches for protein biomarker verification. J Proteomics 74:2650-2659
7. Hua S, Lebrilla C, An HJ (2011) Application of nano-LC-based glycomics towards biomarker discovery. Bioanalysis 3:2573-2585
8. Gibson GT, Mugo SM, Oleschuk RD (2009) Nanoelectrospray emitters: trends and perspective. Mass Spectrom Rev 28:918-936
9. Fortier MH, Bonneil E, Goodley P, Thibault P (2005) Integrated microfluidic device for mass spectrometry-based proteomics and its application to biomarker discovery programs. Anal Chem 77:1631-1640
10. Vollmer M, Hörth P, Rozing G, Couté Y, Grimm R, Hochstrasser D, Sanchez JC (2006) Multi-dimensional HPLC/MS of the nucleolar proteome using HPLC-chip/MS. J Sep Sci 29:499-509
11. Callipo L, Foglia P, Gubbiotti R, Samperi R, Laganà A (2009) HPLC-CHIP coupled to a triple quadrupole mass spectrometer for carbonic anhydrase II quantification in human serum. Anal Bioanal Chem 394:811-820
12. Lasserre JP, Nicaud JM, Pagot Y, Joubert-Caron R, Caron M, Hardouin J (2010) First complexomic study of alkane-binding protein complexes in the yeast Yarrowia lipolytica. Talanta 80:1576-1585
13. Froehlich JW, Chu CS, Tang N, Waddell K, Grimm R, Lebrilla CB (2011) Label-free liquid chromatography-tandem mass spectrometry analysis with automated phosphopeptide enrichment reveals dynamic human milk protein phosphorylation during lactation. Anal Biochem 408:136-146
14. Niñonuevo M, An H, Yin H, Killeen K, Grimm R, Ward R et al (2005) Nanoliquid chromatography-mass spectrometry of oligosaccharides employing graphitized carbon chromatography on microchip with a high-accuracy mass analyzer. Electrophoresis 26:3641-3649
15. Niñonuevo MR, Perkins PD, Francis J, Lamotte LM, LoCascio RG, Freeman SL et al (2008) Daily variations in oligosaccharides of human milk determined by microfluidic chips and mass spectrometry. J Agric Food Chem 56:618-626
16. Alley WR Jr, Madera M, Mechref Y, Novotny MV (2010) Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancer-biomarker discovery. Anal Chem 82:5095-5106
17. Zhu KY, Leung KW, Ting AK, Wong ZC, Ng WY, Choi RC et al (2012) Microfluidic chip based nano liquid chromatography coupled to tandem mass spectrometry for the determination of abused drugs and metabolites in human hair. Anal Bioanal Chem 402:2805-2815
18. Flamini R, De Rosso M, Smaniotto A, Panighel A, Vedova AD, Seraglia R et al (2009) Fast analysis of isobaric grape anthocyanins by Chip-liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 23:2891-2896
19. Liu HY, Lin SL, Chan SA, Lin TY, Fuh MR (2013) Microfluidic chip-based nano-liquid chromatography tandem mass spectrometry for quantification of aflatoxins in peanut products. Talanta 113:76-81
20. Buckenmaier S, Vollmer M, Trojer L, Emotte C (2008) A small molecule HPLC-Chip for the high-sensitivity quantification of pharmaceuticals using triple quadrupole MS. LC-GC Europe, Application Book, pp 25-27
21. Zhao C, Wu Z, Xue G, Wang J, Zhao Y, Xu Z et al (2011) Ultra-high capacity liquid chromatography chip/quadrupole time-of-flight mass spectrometry for pharmaceutical analysis. J Chromatogr A 1218:3669-3674
22. Bai HY, Lin SL, Chan SA, Fuh MR (2010) Characterization and evaluation of two-dimensional microfluidic chip-HPLC coupled to tandem mass spectrometry for quantitative analysis of 7-aminoflunitrazepam in human urine. Analyst 135:2737-2742
23. Zhu KY, Leung KW, Ting AK, Wong ZC, Fu Q, Ng WY et al (2011) The establishment of a highly sensitive method in detecting ketamine and norketamine simultaneously in human hairs by HPLC-Chip-MS/MS. Forensic Sci Int 208:53-58
24. Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A (2001) Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin Cancer Res 7:2182-2194
25. Ramesh M, Ahlawat P, Srinivas NR (2010) Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr 24:104-123
26. Chen X, Peer CJ, Alfaro R, Tian T, Spencer SD, Figg WD (2012) Quantification of irinotecan, SN38, and SN38G in human and porcine plasma by ultra high-performance liquid chromatography-tandem mass spectrometry and its application to hepatic chemoembolization. J Pharm Biomed Anal 62:140-148
27. Goldwirt L, Lemaitre F, Zahr N, Farinotti R, Fernandez C (2012) A new UPLC-MS/MS method for the determination of irinotecan and 7-ethyl-10- hydroxycamptothecin (SN-38) in mice: application to plasma and brain pharmacokinetics. J Pharm Biomed Anal 66:325-333
28. Kummar S, Kinders R, Gutierrez ME, Rubinstein L, Parchment RE, Phillips LR et al (2009) Phase 0 clinical trial of the poly(ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies. J Clin Oncol 27:2705-2711
29. Yin H, Killeen K (2007) The fundamental aspects and applications of Agilent HPLC-Chip. J Sep Sci 30:1427-1434
30. Lappin G, Garner RC (2008) The utility of microdosing over the past 5 years. Expert Opin Drug Metab Toxicol 4:1499-1506
31. Guichard S, Chatelut E, Lochon I, Bugat R, Mahjoubi M, Canal P (1998) Comparison of the pharmacokinetics and efficacy of irinotecan after administration by the intravenous versus intraperitoneal route in mice. Cancer Chemother Pharmacol 42:165-170