Evaluation of the absorption of methotrexate on cells and its cytotoxicity assay by using an integrated microfluidic device coupled to a mass spectrometer

Analytical Chemistry

Volumn 84, Issue 21, 2012, Pages 9230-9237

  Gao, Dan ^a   Li, Haifang ^a   Wang, Niejun ^a   Lin, Jin Ming ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC CELLS; CACO-2 CELLS; COMBINATION SYSTEMS; CULTURE CHAMBERS; CYTOTOXICITY ASSAYS; DOSE-DEPENDENT; DRUG ABSORPTION; DRUG CONCENTRATION; DRUG SCREENING; HIGH SENSITIVITY; HIGH-THROUGHPUT; INTEGRATED MICROFLUIDIC DEVICES; MASS ANALYSIS; MICRO-SCALES; ON CHIPS; QUADRUPOLES; SAMPLE PRETREATMENT; SINGLE-STEP; SOLID-PHASE EXTRACTION COLUMNS; TIME-OF-FLIGHT MASS SPECTROMETERS;

CELL CULTURE; CYTOTOXICITY; ELECTROSPRAY IONIZATION; FLUIDIC DEVICES; MASS SPECTROMETERS;

DRUG DOSAGE;

ANTINEOPLASTIC AGENT; METHOTREXATE;

ABSORPTION; APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL STRAIN HEPG2; DRUG EFFECT; EQUIPMENT; HUMAN; INTRACELLULAR SPACE; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MICROFLUIDIC ANALYSIS; ORAL DRUG ADMINISTRATION; SYSTEM ANALYSIS; THEORETICAL MODEL;

ABSORPTION; ADMINISTRATION, ORAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HEP G2 CELLS; HUMANS; INTRACELLULAR SPACE; MASS SPECTROMETRY; METHOTREXATE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, THEORETICAL; SYSTEMS INTEGRATION;

EID: 84868531310     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac301966c     Document Type: Article

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