Improving sensitivity in microchip electrophoresis coupled to ESI-MS/MS on the example of a cardiac drug mixture

Electrophoresis

Volumn 35, Issue 12-13, 2014, Pages 1880-1886

  Schwarzkopf, Fabian ^a   Scholl, Tobias ^a   Ohla, Stefan ^a   Belder, Detlev ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Glass chip; Mass spectrometry; Microchip electrophoresis; Monolithic emitter; Sensitivity

Indexed keywords

DRUG PRODUCTS; ELECTROPHORESIS; GLASS; MASS SPECTROMETERS; MICROPROCESSOR CHIPS;

CARDIAC DRUGS; ESI-MS-MS; GLASS CHIPS; MASS SPECTROMETRIC DETECTION; MICROCHIP ELECTROPHORESIS; MONOLITHIC EMITTER; MONOLITHICS; SENSITIVITY; SENSITIVITY OPTIMIZATION; SHEATH FLOWS;

MASS SPECTROMETRY;

BISOPROLOL; CARDIOVASCULAR AGENT; LIDOCAINE; PROCAINE; PROPRANOLOL; SPARFLOXACIN;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG MIXTURE; ELECTRIC FIELD; ELECTROSPRAY MASS SPECTROMETRY; FLUORESCENCE MICROSCOPY; IONIZATION; LIMIT OF DETECTION; MASS SPECTROMETER; MICROCHIP ELECTROPHORESIS; PH; SEPARATION TECHNIQUE; URINALYSIS; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; HUMAN; PROCEDURES; TANDEM MASS SPECTROMETRY; URINE;

CARDIOVASCULAR AGENTS; ELECTROPHORESIS, MICROCHIP; EQUIPMENT DESIGN; HUMANS; LIMIT OF DETECTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84903637511     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201300615     Document Type: Article

References (40)

1. Abgrall, P., Gué, A.-M., J. Micromech. Microeng. 2007, 17, R15-R49.
2. Kovarik, M. L., Ornoff, D. M., Melvin, A. T., Dobes, N. C., Wang, Y., Dickinson, A. J., Gach, P. C., Shah, P.K., Allbritton, N. L., Anal. Chem. 2013, 85, 451-472.
3. Whitesides, G. M., Nature 2006, 442, 368-373.
4. Nge, P. N., Rogers, C. I., Woolley, A. T., Chem. Rev. 2013, 113, 2550-2583.
5. Belder, D., Angew. Chem. Int. Ed. 2009, 48, 3736-3737.
6. Janasek, D., Franzke, J., Manz, A., Nature 2006, 442, 374-380.
7. Chao, T.-C., Hansmeier, N., Proteomics 2013, 13, 467-479.
8. Freire, S. L. S., Wheeler, A. R., Lab Chip 2006, 6, 1415-1423.
9. Trouillon, R., Passarelli, M. K., Wang, J., Kurczy, M. E., Ewing, A. G., Anal. Chem. 2013, 85, 522-542.
10. Neužil, P., Giselbrecht, S., Länge, K., Huang, T. J., Manz, A., Nat. Rev. Drug Discovery 2012, 11, 620-632.
11. Shang, F., Guihen, E., Glennon, J. D., Electrophoresis 2012, 33, 105-116.
12. Al-Hetlani, E., Electrophoresis 2013, 34, 1262-1272.
13. Jokerst, J. C., Emory, J. M., Henry, C. S., Analyst 2012, 137, 24-34.
14. Asensio-Ramos, M., Hernández-Borges, J., Rocco, A., Fanali, S., J. Sep. Sci. 2009, 32, 3764-3800.
15. Escarpa, A., González, M. C., Gil, M. A. L., Crevillén, A. G., Hervás, M., García, M., Electrophoresis 2008, 29, 4852-4861.
16. de Kort, B. J., de Jong, G. J., Somsen, G. W., Anal. Chim. Acta 2013, 766, 13-33.
17. Mogensen, K. B., Kutter, J. P., Electrophoresis 2009, 30, S92-S100.
18. Schulze, P., Belder, D., Anal. Bioanal. Chem. 2009, 393, 515-525.
19. Craig, D. B., Dovichi, N. J., Anal. Chem. 1998, 70, 2493-2494.
20. Gibson, G. T. T., Mugo, S. M., Oleschuk, R. D., Mass Spec. Rev. 2009, 28, 918-936.
21. Wilm, M. S., Mann, M., Int. J. Mass Spectrom. Ion Processes 1994, 136, 167-180.
22. Karas, M., Bahr, U., Dülcks, T., Fresenius J. Anal. Chem. 2000, 366, 669-676.
23. Schmidt, A., Karas, M., Dülcks, T., J. Am. Soc. Mass Spectrom. 2003, 14, 492-500.
24. Ohla, S., Belder, D. Curr. Opin. Chem. Biol. 2012, 16, 453-459.
25. Sikanen, T., Franssila, S., Kauppila, T., J., Kostiainen, R., Kotiaho, T., Ketola, R. A., Mass Spectrom. Rev. 2010, 29, 351-391.
26. Prudent, M., Girault, H. H., Analyst 2009, 134, 2189-2203.
27. Foret, F., Kusy, P., Electrophoresis 2006, 27, 4877-4887.
28. Gao, D., Liu, H., Jiang, Y., Lin, J.-M., Lab Chip 2013, 13, 3309-3322.
29. Lazar, I. M., Grym, J., Foret, F., Mass Spec. Rev. 2006, 25, 573-594.
30. Mellors, J. S., Gorbounov, V., Ramsey, R. S., Ramsey J. M., Anal. Chem. 2008, 80, 6881-6887.
31. Licklider, L., Wang, X., Desai, A., Tai, Y.-C., Lee, T., Anal. Chem. 2000, 72, 367-375.
32. Kelly, R. T., Page, J. P., Quanzhou, L., Moore, R. J., Orton, D. J., Tang, K., Smith, R. D., Anal. Chem. 2006, 78, 7796-7801.
33. Arscott, S., Le Gac, S., Rolando, C., Sens. Actuat. B 2005, 106, 741-749.
34. Schilling, M., Nigge, W., Rudzinski, A., Neyer, A., Hergenroder, R., Lab Chip 2004, 4, 220-224.
35. Kitagawa, F., Otsuka, K., J. Pharm. Biomed. Anal. 2001, 55, 668-678.
36. Hoffmann, P., Häusig, U., Schulze, P., Belder, D., Angew. Chem. Int. Ed. 2007, 46, 4913-4916.
37. Hoffmann, P., Eschner, M., Fritzsche, S., Belder, D., Anal. Chem. 2009, 81, 7256-7261.
38. Fritzsche, S., Hoffmann, P., Belder, D., Lab Chip 2010, 10, 1227-1230.
39. Jacobson, S. C., Hergenröder, R., Koutny, L. B., Warmack, R. J., Ramsey, J. M., Anal. Chem. 1994, 66, 1107-1113.
40. Seller, K., Fan, Z. H., Fluri, K., Harrison, D. J., Anal. Chem. 1994, 66, 3485-3491.