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Volumn 45, Issue 6, 2014, Pages 2475-2485

Possible contribution of aminopeptidase N (APN/CD13) to migration and invasion of human osteosarcoma cell lines

Author keywords

Aminopeptidase N; Matrix metalloproteinase; Metastasis; Osteosarcoma

Indexed keywords

BESTATIN; LEUCINE; MESSENGER RNA; MICROSOMAL AMINOPEPTIDASE;

EID: 84907701405     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2664     Document Type: Article
Times cited : (28)

References (56)
  • 1
    • 77953669219 scopus 로고    scopus 로고
    • The epidemiology of osteosarcoma
    • Ottaviani G and Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res 152:3-13, 2009.
    • (2009) Cancer Treat Res , vol.152 , pp. 3-13
    • Ottaviani, G.1    Jaffe, N.2
  • 2
    • 3843144251 scopus 로고    scopus 로고
    • Soft Tissue Sarcoma Committee of the Children's Oncology Group: Late events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: A report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
    • Sung L, Anderson JR, Donaldson SS, Spunt SL, Crist WM, Pappo AS; Soft Tissue Sarcoma Committee of the Children's Oncology Group: Late events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. Eur J Cancer 40:1878-1885, 2004.
    • (2004) Eur J Cancer , vol.40 , pp. 1878-1885
    • Sung, L.1    Anderson, J.R.2    Donaldson, S.S.3    Spunt, S.L.4    Crist, W.M.5    Pappo, A.S.6
  • 3
    • 1942454714 scopus 로고    scopus 로고
    • Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines
    • Cheng YY, Huang L, Lee KM, Li K and Kumta SM: Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines. Pediatr Blood Cancer 42:410-415, 2004.
    • (2004) Pediatr Blood Cancer , vol.42 , pp. 410-415
    • Cheng, Y.Y.1    Huang, L.2    Lee, K.M.3    Li, K.4    Kumta, S.M.5
  • 4
    • 36949040617 scopus 로고    scopus 로고
    • Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression
    • Cho HJ, Lee TS, Park JB, et al: Disulfiram suppresses invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. J Biochem Mol Biol 40:1069-1076, 2007.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 1069-1076
    • Cho, H.J.1    Lee, T.S.2    Park, J.B.3
  • 5
    • 69249136273 scopus 로고    scopus 로고
    • Risedronate inhibits human osteosarcoma cell invasion
    • Xin ZF, Kim YK and Jung ST: Risedronate inhibits human osteosarcoma cell invasion. J Exp Clin Cancer Res 28:105, 2009.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 105
    • Xin, Z.F.1    Kim, Y.K.2    Jung, S.T.3
  • 6
    • 71549169276 scopus 로고    scopus 로고
    • Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells
    • Fan DG, Dai JY, Tang J, et al: Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells. Cell Biol Int 33:1263-1267, 2009.
    • (2009) Cell Biol Int , vol.33 , pp. 1263-1267
    • Fan, D.G.1    Dai, J.Y.2    Tang, J.3
  • 7
    • 33747473703 scopus 로고    scopus 로고
    • Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma
    • Dass CR, Nadesapillai AP, Robin D, et al: Downregulation of uPAR confirms link in growth and metastasis of osteosarcoma. Clin Exp Metastasis 22:643-652, 2005.
    • (2005) Clin Exp Metastasis , vol.22 , pp. 643-652
    • Dass, C.R.1    Nadesapillai, A.P.2    Robin, D.3
  • 8
    • 70349440966 scopus 로고    scopus 로고
    • Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin
    • Wan X, Kim SY, Guenther LM, et al: Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin. Oncogene 28:3401-3411, 2009.
    • (2009) Oncogene , vol.28 , pp. 3401-3411
    • Wan, X.1    Kim, S.Y.2    Guenther, L.M.3
  • 9
    • 0036888309 scopus 로고    scopus 로고
    • Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma
    • Haydon RC, Deyrup A, Ishikawa A, et al: Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer 102:338-342, 2002.
    • (2002) Int J Cancer , vol.102 , pp. 338-342
    • Haydon, R.C.1    Deyrup, A.2    Ishikawa, A.3
  • 10
    • 0142029993 scopus 로고    scopus 로고
    • Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis
    • Iwaya K, Ogawa H, Kuroda M, Izumi M, Ishida T and Mukai K: Cytoplasmic and/or nuclear staining of beta-catenin is associated with lung metastasis. Clin Exp Metastasis 20:525-529, 2003.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 525-529
    • Iwaya, K.1    Ogawa, H.2    Kuroda, M.3    Izumi, M.4    Ishida, T.5    Mukai, K.6
  • 11
    • 64549149292 scopus 로고    scopus 로고
    • Notch signaling contributes to the pathogenesis of human osteosarcomas
    • Engin F, Bertin T, Ma O, et al: Notch signaling contributes to the pathogenesis of human osteosarcomas. Hum Mol Genet 18:1464-1470, 2009.
    • (2009) Hum Mol Genet , vol.18 , pp. 1464-1470
    • Engin, F.1    Bertin, T.2    Ma, O.3
  • 12
    • 77953674754 scopus 로고    scopus 로고
    • How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize
    • Hughes DP: How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. Cancer Treat Res 152:479-496, 2009.
    • (2009) Cancer Treat Res , vol.152 , pp. 479-496
    • Hughes, D.P.1
  • 13
    • 77954375987 scopus 로고    scopus 로고
    • Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/ß-catenin antagonists against human osteosarcoma cells
    • Leow PC, Tian Q, Ong ZY, Yang Z and Ee PL: Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/ß-catenin antagonists against human osteosarcoma cells. Invest New Drugs 28:766-782, 2010.
    • (2010) Invest New Drugs , vol.28 , pp. 766-782
    • Leow, P.C.1    Tian, Q.2    Ong, Z.Y.3    Yang, Z.4    Ee, P.L.5
  • 14
    • 84861910687 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling
    • Li Y, Zhang J, Ma D, et al: Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling. FEBS J 279:2247-2259, 2012.
    • (2012) FEBS J , vol.279 , pp. 2247-2259
    • Li, Y.1    Zhang, J.2    Ma, D.3
  • 15
    • 84868455967 scopus 로고    scopus 로고
    • IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma
    • Lin YM, Chang ZL, Liao YY, Chou MC and Tang CH: IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. Cancer Lett 328:135-143, 2013.
    • (2013) Cancer Lett , vol.328 , pp. 135-143
    • Lin, Y.M.1    Chang, Z.L.2    Liao, Y.Y.3    Chou, M.C.4    Tang, C.H.5
  • 16
    • 77953574880 scopus 로고    scopus 로고
    • Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration
    • Berdiaki A, Datsis GA, Nikitovic D, et al: Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration. IUBMB Life 62:377-386, 2010.
    • (2010) IUBMB Life , vol.62 , pp. 377-386
    • Berdiaki, A.1    Datsis, G.A.2    Nikitovic, D.3
  • 17
    • 34547131814 scopus 로고    scopus 로고
    • Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma
    • Yang R, Hoang BH, Kubo T, et al: Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma. Int J Cancer 121:943-954, 2007.
    • (2007) Int J Cancer , vol.121 , pp. 943-954
    • Yang, R.1    Hoang, B.H.2    Kubo, T.3
  • 18
    • 29744454928 scopus 로고    scopus 로고
    • Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours
    • Dobashi Y, Watanabe H, Matsubara M, et al: Autocrine motility factor/glucose-6-phosphate isomerase is a possible predictor of metastasis in bone and soft tissue tumours. J Pathol 208:44-53, 2006.
    • (2006) J Pathol , vol.208 , pp. 44-53
    • Dobashi, Y.1    Watanabe, H.2    Matsubara, M.3
  • 19
    • 78549268818 scopus 로고    scopus 로고
    • Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis
    • Niinaka Y, Harada K, Fujimuro M, et al: Silencing of autocrine motility factor induces mesenchymal-to-epithelial transition and suppression of osteosarcoma pulmonary metastasis. Cancer Res 70:9483-9493, 2010.
    • (2010) Cancer Res , vol.70 , pp. 9483-9493
    • Niinaka, Y.1    Harada, K.2    Fujimuro, M.3
  • 20
    • 79959507266 scopus 로고    scopus 로고
    • CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis
    • Fromigue O, Hamidouche Z, Vaudin P, et al: CYR61 downregulation reduces osteosarcoma cell invasion, migration, and metastasis. J Bone Miner Res 26:1533-1542, 2011.
    • (2011) J Bone Miner Res , vol.26 , pp. 1533-1542
    • Fromigue, O.1    Hamidouche, Z.2    Vaudin, P.3
  • 21
    • 0842308319 scopus 로고    scopus 로고
    • Transmembrane proteases in cell growth and invasion: New contributors to angiogenesis?
    • Bauvois B: Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis? Oncogene 23:317-329, 2004.
    • (2004) Oncogene , vol.23 , pp. 317-329
    • Bauvois, B.1
  • 24
    • 0033763723 scopus 로고    scopus 로고
    • Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines
    • Kido A, Krueger S, Haeckel C and Roessner A: Possible contribution of aminopeptidase N (APN/CD13) to invasive potential enhanced by interleukin-6 and soluble interleukin-6 receptor in human osteosarcoma cell lines. Clin Exp Metastasis 17:857-863, 1999.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 857-863
    • Kido, A.1    Krueger, S.2    Haeckel, C.3    Roessner, A.4
  • 25
    • 0029100416 scopus 로고
    • Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13
    • Fujii H, Nakajima M, Saiki I, Yoneda J, Azuma I and Tsuruo T: Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13. Clin Exp Metastasis 13:337-344, 1995.
    • (1995) Clin Exp Metastasis , vol.13 , pp. 337-344
    • Fujii, H.1    Nakajima, M.2    Saiki, I.3    Yoneda, J.4    Azuma, I.5    Tsuruo, T.6
  • 26
    • 0347626098 scopus 로고    scopus 로고
    • Biological significance of aminopeptidase N/CD13 in thyroid carcinomas
    • Kehlen A, Lendeckel U, Dralle H, Langner J and Hoang-Vu C: Biological significance of aminopeptidase N/CD13 in thyroid carcinomas. Cancer Res 63:8500-8506, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8500-8506
    • Kehlen, A.1    Lendeckel, U.2    Dralle, H.3    Langner, J.4    Hoang-Vu, C.5
  • 27
    • 34347407791 scopus 로고    scopus 로고
    • CD13/APN regulates endothelial invasion and filopodia formation
    • Petrovic N, Schacke W, Gahagan JR, et al: CD13/APN regulates endothelial invasion and filopodia formation. Blood 110:142-150, 2007.
    • (2007) Blood , vol.110 , pp. 142-150
    • Petrovic, N.1    Schacke, W.2    Gahagan, J.R.3
  • 28
    • 74949120352 scopus 로고    scopus 로고
    • Expression of VEGF, HGF, IL-6, IL-8, MMP-9, telomerase in peripheral blood of patients with head and neck squamous cell carcinoma
    • Hong DY, Lee BJ, Lee JC, Choi JS, Wang SG and Ro JH: Expression of VEGF, HGF, IL-6, IL-8, MMP-9, telomerase in peripheral blood of patients with head and neck squamous cell carcinoma. Clin Exp Otorhinolaryngol 2:186-192, 2009.
    • (2009) Clin Exp Otorhinolaryngol , vol.2 , pp. 186-192
    • Hong, D.Y.1    Lee, B.J.2    Lee, J.C.3    Choi, J.S.4    Wang, S.G.5    Ro, J.H.6
  • 29
    • 35248822806 scopus 로고    scopus 로고
    • Pro-inflammatory cytokine, matrix metalloproteinases and TIMP-1 are involved in wound healing after mastectomy in invasive breast cancer patients
    • Loo WT, Sasano H and Chow LW: Pro-inflammatory cytokine, matrix metalloproteinases and TIMP-1 are involved in wound healing after mastectomy in invasive breast cancer patients. Biomed Pharmacother 61:548-552, 2007.
    • (2007) Biomed Pharmacother , vol.61 , pp. 548-552
    • Loo, W.T.1    Sasano, H.2    Chow, L.W.3
  • 30
    • 0033988558 scopus 로고    scopus 로고
    • The relation of gelatinase (MMP-2 and -9) expression with distant site metastasis and tumour aggressiveness in colorectal cancer
    • Güllü IH, Kurdoʇlu M and Akalin I: The relation of gelatinase (MMP-2 and -9) expression with distant site metastasis and tumour aggressiveness in colorectal cancer. Br J Cancer 82:249, 2000.
    • (2000) Br J Cancer , vol.82 , pp. 249
    • Güllü, I.H.1    Kurdoʇlu, M.2    Akalin, I.3
  • 31
    • 0033915538 scopus 로고    scopus 로고
    • The significance of MMP-1 and MMP-2 in peritoneal disseminated metastasis of gastric cancer
    • Mizutani K, Kofuji K and Shirouzu K: The significance of MMP-1 and MMP-2 in peritoneal disseminated metastasis of gastric cancer. Surg Today 30:614-621, 2000.
    • (2000) Surg Today , vol.30 , pp. 614-621
    • Mizutani, K.1    Kofuji, K.2    Shirouzu, K.3
  • 32
    • 78650824229 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma
    • Korpi JT, Hagström J, Lehtonen N, et al: Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma. Surg Oncol 20: el8-e22, 2011.
    • (2011) Surg Oncol , vol.20 , pp. el8-e22
    • Korpi, J.T.1    Hagström, J.2    Lehtonen, N.3
  • 33
    • 4444320486 scopus 로고    scopus 로고
    • Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: Findings in 42 patients followed for 1-16 years
    • Ferrari C, Benassi S, Ponticelli F, et al: Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years. Acta Orthop Scand 75:487-491, 2004.
    • (2004) Acta Orthop Scand , vol.75 , pp. 487-491
    • Ferrari, C.1    Benassi, S.2    Ponticelli, F.3
  • 35
    • 0031789028 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma
    • Himelstein BP, Asada N, Carlton MR and Collins MH: Matrix metalloproteinase-9 (MMP-9) expression in childhood osseous osteosarcoma. Med Pediatr Oncol 31:471-474, 1998.
    • (1998) Med Pediatr Oncol , vol.31 , pp. 471-474
    • Himelstein, B.P.1    Asada, N.2    Carlton, M.R.3    Collins, M.H.4
  • 36
    • 0032516898 scopus 로고    scopus 로고
    • Transcriptional activation of the p21 (WAFl, CIPl, SDIl) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells
    • Bellido T, O'Brien CA, Roberson PK and Manolagas SC: Transcriptional activation of the p21 (WAFl, CIPl, SDIl) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. J Biol Chem 273:21137-21144, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 21137-21144
    • Bellido, T.1    O'Brien, C.A.2    Roberson, P.K.3    Manolagas, S.C.4
  • 37
    • 0030664646 scopus 로고    scopus 로고
    • Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts
    • Franchimont N, Gangji V, Durant D and Canalis E: Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts. Endocrinology 138:5248-5255, 1997.
    • (1997) Endocrinology , vol.138 , pp. 5248-5255
    • Franchimont, N.1    Gangji, V.2    Durant, D.3    Canalis, E.4
  • 38
  • 39
    • 0031966146 scopus 로고    scopus 로고
    • Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells
    • Nishimura R, Moriyama K, Yasukawa K, Mundy GR and YonedaT: Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells. J Bone Miner Res 13:777-785, 1998.
    • (1998) J Bone Miner Res , vol.13 , pp. 777-785
    • Nishimura, R.1    Moriyama, K.2    Yasukawa, K.3    Mundy, G.R.4    Yoneda, T.5
  • 40
    • 0031885821 scopus 로고    scopus 로고
    • Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators
    • Kehlen A, Göhring B, Langner J and Riemann D: Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators. Clin Exp Immunol 111:435-441, 1998.
    • (1998) Clin Exp Immunol , vol.111 , pp. 435-441
    • Kehlen, A.1    Göhring, B.2    Langner, J.3    Riemann, D.4
  • 41
    • 77950455995 scopus 로고    scopus 로고
    • Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9
    • Chen YY, Chiang SY, Lin JG, et al: Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9. Int J Oncol 36:1113-1120, 2010.
    • (2010) Int J Oncol , vol.36 , pp. 1113-1120
    • Chen, Y.Y.1    Chiang, S.Y.2    Lin, J.G.3
  • 42
    • 70449428545 scopus 로고    scopus 로고
    • Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9
    • Lin CC, Chen JT, Yang JS, et al: Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. Oncol Rep 22:1033-1037, 2009.
    • (2009) Oncol Rep , vol.22 , pp. 1033-1037
    • Lin, C.C.1    Chen, J.T.2    Yang, J.S.3
  • 43
    • 77949351356 scopus 로고    scopus 로고
    • Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway
    • Lai KC, Huang AC, Hsu SC, et al: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. J Agric Food Chem 58:2935-2942, 2010.
    • (2010) J Agric Food Chem , vol.58 , pp. 2935-2942
    • Lai, K.C.1    Huang, A.C.2    Hsu, S.C.3
  • 44
    • 79955796236 scopus 로고    scopus 로고
    • Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways
    • Liu KC, Huang AC, Wu PP, et al: Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways. Oncol Rep 26:177-184, 2011.
    • (2011) Oncol Rep , vol.26 , pp. 177-184
    • Liu, K.C.1    Huang, A.C.2    Wu, P.P.3
  • 45
    • 78651497947 scopus 로고    scopus 로고
    • Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways
    • Chiang JH, Yang JS, Ma CY, et al: Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways. Chem Res Toxicol 24:20-29, 2011.
    • (2011) Chem Res Toxicol , vol.24 , pp. 20-29
    • Chiang, J.H.1    Yang, J.S.2    Ma, C.Y.3
  • 46
    • 70449627030 scopus 로고    scopus 로고
    • Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice
    • Wen YF, Yang JS, Kuo SC, et al: Investigation of anti-leukemia molecular mechanism of ITR-284, a carboxamide analog, in leukemia cells and its effects in WEHI-3 leukemia mice. Biochem Pharmacol 79:389-398, 2010.
    • (2010) Biochem Pharmacol , vol.79 , pp. 389-398
    • Wen, Y.F.1    Yang, J.S.2    Kuo, S.C.3
  • 48
    • 24944553549 scopus 로고    scopus 로고
    • MAP kinase pathways
    • Qi M and Elion EA: MAP kinase pathways. J Cell Sci 118:3569-3572, 2005.
    • (2005) J Cell Sci , vol.118 , pp. 3569-3572
    • Qi, M.1    Elion, E.A.2
  • 49
    • 0035008915 scopus 로고    scopus 로고
    • Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells
    • Bond M, Chase AJ, Baker AH and Newby AC: Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells. Cardiovasc Res 50:556-565, 2001.
    • (2001) Cardiovasc Res , vol.50 , pp. 556-565
    • Bond, M.1    Chase, A.J.2    Baker, A.H.3    Newby, A.C.4
  • 50
    • 33644875741 scopus 로고    scopus 로고
    • Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: Chemistry, biological evaluations, and therapeutic prospects
    • Bauvois B and Dauzonne D: Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects. Med Res Rev 26:88-130, 2006.
    • (2006) Med Res Rev , vol.26 , pp. 88-130
    • Bauvois, B.1    Dauzonne, D.2
  • 51
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA and Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7:211-217, 2005.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 52
    • 78751549236 scopus 로고    scopus 로고
    • IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
    • Lo CW, Chen MW, Hsiao M, et al: IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res 71:424-434, 2011.
    • (2011) Cancer Res , vol.71 , pp. 424-434
    • Lo, C.W.1    Chen, M.W.2    Hsiao, M.3
  • 53
    • 79953183679 scopus 로고    scopus 로고
    • IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells
    • Tang CH, Chen CF, Chen WM and Fong YC: IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells. J Biol Chem 286:11056-11066, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 11056-11066
    • Tang, C.H.1    Chen, C.F.2    Chen, W.M.3    Fong, Y.C.4
  • 54
    • 84865295971 scopus 로고    scopus 로고
    • STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma
    • Tu B, Du L, Fan QM, Tang Z and Tang TT: STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma. Cancer Lett 325:80-88, 2012.
    • (2012) Cancer Lett , vol.325 , pp. 80-88
    • Tu, B.1    Du, L.2    Fan, Q.M.3    Tang, Z.4    Tang, T.T.5
  • 55
    • 48149111676 scopus 로고    scopus 로고
    • The moonlighting enzyme CD13: Old and new functions to target
    • Mina-Osorio P: The moonlighting enzyme CD13: old and new functions to target. Trends Mol Med 14:361-371, 2008.
    • (2008) Trends Mol Med , vol.14 , pp. 361-371
    • Mina-Osorio, P.1
  • 56
    • 84862830254 scopus 로고    scopus 로고
    • Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways
    • Liao CL, Lai KC, Huang AC, et al: Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways. Food Chem Toxicol 50:1734-1740, 2012.
    • (2012) Food Chem Toxicol , vol.50 , pp. 1734-1740
    • Liao, C.L.1    Lai, K.C.2    Huang, A.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.