Production and optimization of monacolin K by citrinin-free Monascus pilosus MS-1 in solid-state fermentation using non-glutinous rice and soybean flours as substrate

European Food Research and Technology

Volumn 239, Issue 4, 2014, Pages 629-636

  Feng, Yanli ^a   Shao, Yanchun ^a   Zhou, Youxiang ^b   Chen, Fusheng ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Box Behnken design; Citrinin free; Monacolin K; Monascus pilosus MS 1; Solid state fermentation

Indexed keywords

DIETARY SUPPLEMENTS; MAGNESIUM COMPOUNDS; SIEVES; SUBSTRATES;

3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; CITRININ; MONACOLIN K; MONASCUS PILOSUS; OPTIMIZED CONDITIONS; SERUM TRIGLYCERIDE; SOLID-STATE FERMENTATION; TOTAL CHOLESTEROLS;

FERMENTATION;

EID: 84907685527     PISSN: 14382377     EISSN: 14382385     Source Type: Journal    
DOI: 10.1007/s00217-014-2259-z     Document Type: Article

References (28)

1. Endo A (1980) Monacoiln K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme a reductase. J Antibiot XXXIII(3):334–336
2. Valera HR, Gomes J, Lakshmi S, Gururaja R, Suryanarayan S, Kumar D (2005) Lovastatin production by solid state fermentation using Aspergillus flavipes. Enzyme Microb Technol 37(5):521–526
3. Ho BY, Pan TM (2009) The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells. J Agric Food Chem 57(18):8258–8265
4. Endo A (1979) Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. J Antibiot 32:852–854
5. Jůzlová P, Martínková L, Křen V (1996) Secondary metabolites of the fungus Monascus: a review. J Ind Microbiol Biotechnol 16(3):163–170
6. Wild D, Toth G, Humpf HU (2002) New Monascus metabolite isolated from red yeast rice (angkak, red koji). J Agric Food Chem 50(14):3999–4002
7. Cheng MJ, Wu MD, Chen IS, Yuan GF (2010) A new sesquiterpene isolated from the extracts of the fungus Monascus pilosus-fermented rice. Nat Prod Res 24(8):750–758
8. Hong S, Lee I, Kim S, Imm J-Y (2012) Improved functionality of soft soybean curd containing Monascus fermented soybean ethanol extract. Food Sci Biotechnol 21(3):701–707
9. Knecht A, Cramer B, Humpf HU (2006) New Monascus metabolites: structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells. Mol Nutr Food Res 50(3):314–321
10. Liu MT, Li JJ, Shang XY, Li S, Li LL, Luan N, Jin ZL (2011) Structure elucidation and complete NMR spectral assignment of an unusual aromatic monacolin analog from Monascus purpureus-fermented rice. Magn Reson Chem 49(3):129–131
11. Chen YP, Tseng CP, Chien IL, Wang WY, Liaw LL, Yuan GF (2008) Exploring the distribution of citrinin biosynthesis related genes among Monascus species. J Agric Food Chem 56(24):11767–11772
12. Blanc PJ, Loret MO, Goma G (1995) Production of citrinin by various species of Monascus. Biotechnol Lett 17(3):291–294
13. Ajdari Z, Ebrahimpour A, Abdul Manan M, Hamid M, Mohamad R, Ariff AB (2011) Assessment of monacolin in the fermented products using Monascus purpureus FTC5391. J Biomed Biotechnol 2011:1–9
14. Seraman S, Rajendran A, Thangavelu V (2010) Statistical optimization of anticholesterolemic drug lovastatin production by the red mold Monascus purpureus. Food Bioprod Process 88(2–3):266–276
15. Panda B, Javed S, Ali M (2010) Optimization of fermentation parameters for higher lovastatin production in red mold rice through co-culture of Monascus purpureus and Monascus ruber. Food Bioprocess Tech 3(3):373–378
16. Lee CL, Hung HK, Wang JJ, Pan TM (2007) Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem 55(16):6493–6502
17. Venkateswaran V, Vijayalakshmi G (2010) Finger millet (Eleusine coracana)—an economically viable source for antihypercholesterolemic metabolites production by Monascus purpureus. J Food Sci Technol 47(4):426–431
18. Lee CL, Wang JJ, Kuo SL, Pan TM (2006) Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent—monacolin K and antiinflammation agent—monascin. Appl Microbiol Biotechnol 72(6):1254–1262
19. Lu LP, Zhang BB, Xu GR (2013) Efficient conversion of high concentration of glycerol to monacolin K by solid-state fermentation of Monascus purpureus using bagasse as carrier. Bioprocess Biosyst Eng 36(3):293–299
20. Panda B, Javed S, Ali M (2009) Statistical analysis and validation of process parameters influencing lovastatin production by Monascus purpureus MTCC 369 under solid-state fermentation. Biotechnol Bioprocess Eng 14(1):123–127
21. Suh SH, Rheem S, Mah JH, Lee W, Byun MW, Hwang HJ (2007) Optimization of production of monacolin K from γ-irradiated Monascus mutant by use of response surface methodology. J Med Food 10(3):408–415
22. Feng YL, Shao YC, Zhou YX, Chen FS (2014) Monacolin K production by citrinin-free Monascus pilosus MS-1 and fermentation process monitoring. Eng Life Sci. doi:10.1002/elsc.201300128
23. Zhang W, Wen J, Ding YZ, Yao JC, Feng JP, Xie SM (2007) QB/T 2847-2007 Functional red kojic rice (powder). Natl Dev Reform Comm 7–8
24. Xiao ZJ, Liu PH, Qin JY, Xu P (2007) Statistical optimization of medium components for enhanced acetoin production from molasses and soybean meal hydrolysate. Appl Microbiol Biotechnol 74(1):61–68
25. Plackett RL, Jp Burman (1946) The design of optimum multifactorial experiments. Biometrika 33(4):305–325
26. Tan J, Chu J, Shi WJ, Lin C, Guo YX, Zhuang YP, Zhang SL, Imanaka T (2012) High-throughput screening strategy used for enhanced production of pigment by Monascus purpureus D39-4. Food Sci Biotechnol 21(6):1603–1610
27. Tsukahara M, Shinzato N, Tamaki Y, Namihira T, Matsui T (2009) Red yeast rice fermentation by selected Monascus sp. with deep-red color, lovastatin production but no citrinin, and effect of temperature-shift cultivation on lovastatin production. Appl Biochem Biotechnol 158(2):476–482
28. Sayyad SA, Panda BP, Javed S, Ali M (2007) Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology. Appl Microbiol Biotechnol 73(5):1054–1058