Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis

PLoS Pathogens

Volumn 10, Issue 9, 2014, Pages

  Waisberg, Michael ^a,b   Molina Cruz, Alvaro ^a   Mizurini, Daniella M ^c   Gera, Nidhi ^a   Sousa, Beatriz C ^d   Ma, Dongying ^a   Leal, Ana C ^c   Gomes, Tainá ^c   Kotsyfakis, Michalis ^e   Ribeiro, José M C ^a   Lukszo, Jan ^a   Reiter, Karine ^a   Porcella, Stephen F ^f   Oliveira, Carlo J ^d   Monteiro, Robson Q ^c   Barillas Mury, Carolina ^a   Pierce, Susan K ^a   Francischetti, Ivo M B ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d FEDERAL UNIVERSITY OF TRIÂNGULO MINEIRO   (Brazil)

^e INSTITUTE OF PARASITOLOGY   (Czech Republic)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAPHELIN; ELASTASE; LEUKOCYTE ELASTASE; MYELOPEROXIDASE; SALIVA PROTEIN; UNCLASSIFIED DRUG; INSECT PROTEIN;

AFFIMETRIX CHIP MICROARRAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANOPHELES GAMBIAE; ARTERY THROMBOSIS; ARTICLE; CELL FUNCTION; CELL MIGRATION; CHEMOTAXIS ASSAY; CIRCULAR DICHROISM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HEMOSTASIS; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; MALARIA FALCIPARUM; MICROARRAY ANALYSIS; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PAW EDEMA; PROTEIN ANALYSIS; PROTEIN STRUCTURE; QUANTITATIVE ASSAY; RNA EXTRACTION; SURFACE PLASMON RESONANCE; THROMBOCYTE AGGREGATION; THROMBOSIS PREVENTION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; DISEASE CARRIER; EDEMA; GENETICS; HOST PARASITE INTERACTION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PARASITOLOGY; PATHOGENICITY; PHYSIOLOGY; PLASMODIUM FALCIPARUM; SALIVARY GLAND; SEQUENCE HOMOLOGY; THROMBOSIS;

PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES GAMBIAE; CIRCULAR DICHROISM; EDEMA; FEMALE; HEMOSTASIS; HOST-PARASITE INTERACTIONS; INSECT PROTEINS; INSECT VECTORS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PLASMODIUM FALCIPARUM; SALIVARY GLANDS; SALIVARY PROTEINS AND PEPTIDES; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE; THROMBOSIS;

EID: 84907572366     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004338     Document Type: Article

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