Human neutrophil elastase proteolytically activates the platelet integrin α(IIb)β3 through cleavage of the carboxyl terminus of the α(IIb) subunit heavy chain. Involvement in the potentiation of platelet aggregation

Journal of Biological Chemistry

Volumn 272, Issue 17, 1997, Pages 11636-11647

  Si Tahar, Mustapha ^a   Pidard, Dominique ^a   Balloy, Viviane ^a   Moniatte, Marc ^b   Kieffer, Nelly ^c   Van Dorsselaer, Alain ^b   Chignard, Michel ^a  

^a INSERM   (France)

^b UNIVERSITÉ LOUIS PASTEUR   (France)

^c UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; ELASTASE; EPITOPE; FIBRINOGEN RECEPTOR; PLECKSTRIN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL SUBPOPULATION; CHO CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MASS SPECTROMETRY; PREDICTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; THROMBOCYTE AGGREGATION; THROMBOSIS;

AMINO ACID SEQUENCE; ANIMALS; CATHEPSINS; CHO CELLS; CRICETINAE; HUMANS; LEUKOCYTE ELASTASE; MODELS, BIOLOGICAL; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEPTIDE MAPPING; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0030943738     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.17.11636     Document Type: Article

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