Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2α, and 15(S)-HETE

Journal of Biological Chemistry

Volumn 285, Issue 50, 2010, Pages 39001-39012

  Assumpção, Teresa C F ^a   Alvarenga, Patricia H ^a   Ribeiro, José M C ^a   Andersen, John F ^a   Francischetti, Ivo M B ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15-LIPOXYGENASE; 3D MODELS; ANGIOGENESIS; ARACHIDONIC ACIDS; BINDING POCKETS; BINDING SPECIFICITIES; BIOGENIC AMINES; EICOSANOIDS; HIGH AFFINITY; ISOTHERMAL TITRATION CALORIMETRY; LIPOCALIN; PLATELET AGGREGATION; PROSTANOIDS; SALIVARY GLANDS; SEQUENCE SIMILARITY; SMALL MOLECULES;

AGRICULTURAL PRODUCTS; AMINES; COLLAGEN; DRUG PRODUCTS; ESCHERICHIA COLI; LIPIDS; MASS SPECTROMETRY; THREE DIMENSIONAL;

PLATELETS;

12 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; 5 HYDROXYICOSATETRAENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; 8 ISOPROSTAGLANDIN F2 ALPHA; ADENOSINE DIPHOSPHATE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; ARGININE; BIOGENIC AMINE; COLLAGEN; CONVULXIN; DIPETALODIPIN; GLUTAMINE; LEUKOTRIENE DERIVATIVE; LEUKOTRIENE E4; LIPID; LIPOCALIN; PROSTAGLANDIN D2; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN J2; PROSTANOID; RISTOCETIN; SALIVA PROTEIN; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; RAT; SMOOTH MUSCLE RELAXATION; THROMBOCYTE AGGREGATION INHIBITION; UTERUS CONTRACTION; VASOCONSTRICTION;

ANIMALS; AORTA; DINOPROST; FEMALE; HORSES; HYDROXYEICOSATETRAENOIC ACIDS; INSECT PROTEINS; LIPOCALINS; NEOVASCULARIZATION, PATHOLOGIC; PLATELET AGGREGATION; RATS; RATS, WISTAR; SALIVA; SALIVARY GLANDS; THROMBOXANE A2; TRIATOMINAE; UTERUS; VASOCONSTRICTION;

DIPETALOGASTER MAXIMUS; ESCHERICHIA COLI; RATTUS;

EID: 78649858721     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.152835     Document Type: Article

References (50)

1. Ruggeri, Z. M. (2002) Nat. Med. 8, 1227-1234
2. Watson, S. P., Auger, J. M., McCarty, O. J., and Pearce, A. C. (2005) J. Thromb. Haemost. 3, 1752-1762
3. Charkoudian, N. (2003) Mayo Clin Proc. 78, 603-612
4. Ribeiro, J. M., and Francischetti, I. M. (2003) Annu. Rev. Entomol. 48, 73-88
5. Francischetti, I. M. (2010) Toxicon 56, 1130-1144
6. Flower, D. R., North, A. C., and Sansom, C. E. (2000) Biochim. Biophys. Acta 1482, 9-24
7. Francischetti, I. M., Ribeiro, J. M., Champagne, D., and Andersen, J. (2000) J. Biol. Chem. 275, 12639-12650
8. Andersen, J. F., Francischetti, I. M., Valenzuela, J. G., Schuck, P., and Ribeiro, J. M. (2003) J. Biol. Chem. 278, 4611-4617
9. Paesen, G. C., Adams, P. L., Harlos, K., Nuttall, P. A., and Stuart, D. I. (1999) Mol. Cell 3, 661-671
10. Mans, B. J., and Ribeiro, J. M. (2008) Insect Biochem. Mol. Biol. 38, 862-870
11. Champagne, D. E., and Ribeiro, J. M. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 138-142
12. Reddy, V. B., Iuga, A. O., Kounga, K., and Lerner, E. A. (2006) J. Biol. Chem. 281, 16197-16201
13. Andersen, J. F., Champagne, D. E., Weichsel, A., Ribeiro, J. M., Balfour, C. A., Dress, V., and Montfort, W. R. (1997) Biochemistry 36, 4423-4428
14. Francischetti, I. M., Saliou, B., Leduc, M., Carlini, C. R., Hatmi, M., Randon, J., Faili, A., and Bon, C. (1997) Toxicon 35, 1217-1228
15. Assumpção, T. C., Francischetti, I. M., Andersen, J. F., Schwarz, A., Santana, J. M., and Ribeiro, J. M. (2008) Insect Biochem. Mol. Biol. 38, 213-232
16. Calvo, E., Tokumasu, F., Marinotti, O., Villeval, J. L., Ribeiro, J. M., and Francischetti, I. M. (2007) J. Biol. Chem. 282, 26928-26938
17. Francischetti, I. M., Mather, T. N., and Ribeiro, J. M. (2005) Thromb. Haemost 94, 167-174
18. Zhang, B., Cao, H., and Rao, G. N. (2005) Cancer Res. 65, 7283-7291
19. Arnold, K., Bordoli, L., Kopp, J., and Schwede, T. (2006) Bioinformatics 22, 195-201
20. Noeske-Jungblut, C., Krätzschmar, J., Haendler, B., Alagon, A., Possani, L., Verhallen, P., Donner, P., and Schleuning, W. D. (1994) J. Biol. Chem. 269, 5050-5053
21. Morita, A., Isawa, H., Orito, Y., Iwanaga, S., Chinzei, Y., and Yuda, M. (2006) FEBS J. 273, 2955-2962
22. Keller, P. M., Schultz, L. D., Condra, C., Karczewski, J., and Connolly, T. M. (1992) J. Biol. Chem. 267, 6899-6904
23. Mans, B. J., and Ribeiro, J. M. (2008) Insect. Biochem. Mol. Biol. 38, 841-852
24. Paddock, C. D., McKerrow, J. H., Hansell, E., Foreman, K. W., Hsieh, I., and Marshall, N. (2001) J. Immunol. 167, 2694-2699
25. Jung, S. M., and Moroi, M. (1998) J. Biol. Chem. 273, 14827-14837
26. Nakamura, T., Jamieson, G. A., Okuma, M., Kambayashi, J., and Tandon, N. N. (1998) J. Biol. Chem. 273, 4338-4344
27. Jin, R. C., Voetsch, B., and Loscalzo, J. (2005) Microcirculation 12, 247-258
28. Jackson, S. P., and Schoenwaelder, S. M. (2003) Nat. Rev. Drug Discov. 2, 775-789
29. Mumford, A. D., Dawood, B. B., Daly, M. E., Murden, S. L., Williams, M. D., Protty, M. B., Spalton, J. C., Wheatley, M., Mundell, S. J., and Watson, S. P. (2010) Blood 115, 363-369
30. Moers, A., Wettschureck, N., Grüner, S., Nieswandt, B., and Offermanns, S. (2004) J. Biol. Chem. 279, 45354-45359
31. Gibbins, J. M. (2004) J. Cell Sci. 117, 3415-3425
32. Cosemans, J. M., Kuijpers, M. J., Lecut, C., Loubele, S. T., Heeneman, S., Jandrot-Perrus, M., and Heemskerk, J. W. (2005) Atherosclerosis 181, 19-27
33. Kahner, B. N., Shankar, H., Murugappan, S., Prasad, G. L., and Kunapuli, S. P. (2006) J Thromb Haemost 4, 2317-2326
34. Jung, S. M., and Moroi, M. (2000) Trends Cardiovasc. Med. 10, 285-292
35. Varga-Szabo, D., Pleines, I., and Nieswandt, B. (2008) Arterioscler. Thromb. Vasc. Biol. 28, 403-412
36. Gawaz, M., Langer, H., and May, A. E. (2005) J. Clin. Invest. 115, 3378-3384
37. Praticò, D. (2008) Atherosclerosis 201, 8-16
38. Félétou, M., Vanhoutte, P. M., and Verbeuren, T. J. (2010) J. Cardiovasc. Pharmacol. 55, 317-332
39. Tang, E. H., and Vanhoutte, P. M. (2009) Pharmacol Ther. 122, 140-149
40. Boyce, J. A. (2005) Chem. Immunol. Allergy 87, 59-79
41. Shimura, C., Satoh, T., Igawa, K., Aritake, K., Urade, Y., Nakamura, M., and Yokozeki, H. (2010) Am J. Pathol. 176, 227-237
42. Patricia, M. K., Kim, J. A., Harper, C. M., Shih, P. T., Berliner, J. A., Natarajan, R., Nadler, J. L., and Hedrick, C. C. (1999) Arterioscler. Thromb. Vasc. Biol. 19, 2615-2622
43. Sordillo, L. M., Streicher, K. L., Mullarky, I. K., Gandy, J. C., Trigona, W., and Corl, C. M. (2008) Free Radic Biol. Med. 44, 34-43
44. Reilly, K. B., Srinivasan, S., Hatley, M. E., Patricia, M. K., Lannigan, J., Bolick, D. T., Vandenhoff, G., Pei, H., Natarajan, R., Nadler, J. L., and Hedrick, C. C. (2004) J. Biol. Chem. 279, 9440-9450
45. Legler, D. F., Bruckner, M., Uetz-von Allmen, E., and Krause, P. (2010) Int. J. Biochem. Cell Biol. 42, 198-201
46. Calvo, E., Mans, B. J., Andersen, J. F., and Ribeiro, J. M. (2006) J. Biol. Chem. 281, 1935-1942
47. Mans, B. J., Andersen, J. F., Schwan, T. G., and Ribeiro, J. M. (2008) Insect Biochem. Mol. Biol. 38, 22-41
48. Sangamnatdej, S., Paesen, G. C., Slovak, M., and Nuttall, P. A. (2002) Insect Mol. Biol. 11, 79-86
49. Tang, L., Ding, T., and Praticò, D. (2008) Atherosclerosis 199, 265-270
50. Firuzi, O., Zhuo, J., Chinnici, C. M., Wisniewski, T., and Praticò, D. (2008) FASEB J. 22, 1169-1178