Chloroquine is a zinc ionophore

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Xue, Jing ^a,b   Moyer, Amanda ^a   Peng, Bing ^a,c   Wu, Jinchang ^b   Hannafon, Bethany N ^a   Ding, Wei Qun ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b NANJING MEDICAL UNIVERSITY   (China)

^c XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; COPPER ION; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; ZINC ION; FLUORESCENT DYE; ZINC;

ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; DRUG STRUCTURE; DRUG TARGETING; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LYSOSOME; CELL LINE; CHEMISTRY; TUMOR CELL LINE;

CELL LINE; CELL LINE, TUMOR; CHLOROQUINE; FEMALE; FLUORESCENT DYES; HUMANS; ZINC;

EID: 84907546078     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109180     Document Type: Article

References (31)

1. Krafts K, Hempelmann E, Skorska-Stania A (2012). From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy. Parasitol Res 111: 1-6.
2. Lamoureux F, Zoubeidi A (2013). Dual inhibition of autophagy and the AKT pathway in prostate cancer. Autophagy 9: 1119-1120.
3. Eldredge HB, Denittis A, Duhadaway JB, Chernick M, Metz R, et al. (2013) Concurrent Whole Brain Radiotherapy and Short-Course Chloroquine in Patients with Brain Metastases: A Pilot Trial. J Radiat Oncol 2.
4. Goldberg SB, Supko JG, NealJW, Muzikansky A, Digumarthy S, et al. (2012). A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer. J Thorac Oncol 7: 1602-1608.
5. Rojas-Puentes LL, Gonzalez-Pinedo M, Crismatt A, Ortega-Gomez A, Gambo-Vignolle C, et al. (2013). Phase II randomized, double-blind, placebo-controlled study of whole-brain irradiation with concomitant chloroquine for brain metastases. Radiat Oncol 8: 209.
6. Zou Y, Ling YH, Sironi J, Schwartz EL, Perez-Soler R, et al. (2013). The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib. J Thorac Oncol 8: 693-702.
7. Selvakumaran M, Amaravadi RK, Vasilevskaya IA, O'Dwyer PJ (2013). Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy. Clin Cancer Res 19: 2995-3007.
8. Zinn RL, Gardner EE, Dobromilskaya I, Murphy S, Marchionni L, et al. (2013). Combination treatment with ABT-737 and chloroquine in preclinical models of small cell lung cancer. Mol Cancer 12: 16.
9. Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, et al. (2012). Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 8: 200-212.
10. Kimura T, Takabatake Y, Takahashi A, Isaka Y (2013). Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res 73: 3-7.
11. Bristol ML, Emery SM, Maycotte P, Thorburn A, Chakradeo S, et al. (2013) Autophagy inhibition for chemosensitization and radio sensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther 344: 544-552.
12. Solomon VR, Lee H (2009). Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 625: 220-233.
13. Mizushima N, Yoshimori T, Levine B (2010). Methods in mammalian autophagy research. Cell 140: 313-326.
14. Lamoureux F, Thomas C, Crafter C, Kumano M, Zhang F, et al. (2013). Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. Clin Cancer Res 19: 833-844.
15. Yu H, Zhou Y, Lind SE, Ding WQ (2009) Clioquinol targets zinc to lysosomes in human cancer cells. Biochem J 417: 133-139.
16. Zheng J, Zhang XX, Yu H, Taggart JE, Ding WQ (2012). Zinc at cytotoxic concentrations affects posttranscriptional events of gene expression in cancer cells. Cell Physiol Biochem 29: 181-188.
17. Ding WQ, Lind SE (2009). Metal ionophores - An emerging class of anticancer drugs. IUBMB Life 61: 1013-1018.
18. Liuzzi JP, Yoo C (2013) Role of Zinc in the Regulation of Autophagy During Ethanol Exposure in Human Hepatoma Cells. Biol Trace Elem Res.
19. Blackie MA (2013). Metal containing chloroquinolines: beyond hit and miss antimalarial efficacy to solid science. Mini Rev Med Chem 13: 597-606.
20. Ding WQ, Liu B, Vaught JL, Yamauchi H, Lind SE (2005). Anticancer activity of the antibiotic clioquinol. Cancer Res 65: 3389-3395.
21. Ding WQ, Liu B, Vaught JL, Palmiter RD, Lind SE (2006). Clioquinol and docosahexaenoic acid act synergistically to kill tumor cells. Mol Cancer Ther 5: 1864-1872.
22. Canzoniero LM, Manzerra P, Sheline CT, Choi DW (2003). Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal death. Neuropharmacology 45: 420-428.
23. Ding WQ, Yu HJ, Lind SE (2008). Zinc-binding compounds induce cancer cell death via distinct modes of action. Cancer Lett 271: 251-259.
24. Li M, Khambu B, Zhang H, Kang JH, Chen X, et al. (2013) Suppression of Lysosome Function Induces Autophagy via a Feedback Downregulation of MTORC1 Activity. J Biol Chem.
25. Mercer E, Rekedal L, Garg R, Lu B, Massarotti EM, et al. (2012). Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals. Arthritis Res Ther 14: R135.
26. Solomon DH, Massarotti E, Garg R, Liu J, Canning C, et al. (2011). Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. Jama 305: 2525-2531.
27. Qin Y, Thomas D, Fontaine CP, Colvin RA (2008). Mechanisms of Zn2+ efflux in cultured cortical neurons. J Neurochem 107: 1304-1313.
28. Aiba I, West AK, Sheline CT, Shuttleworth CW (2013). Intracellular dialysis disrupts Zn2+ dynamics and enables selective detection of Zn2+ influx in brain slice preparations. J Neurochem 125: 822-831.
29. Baum L, Ng A (2004). Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. J Alzheimers Dis 6: 367-377;discussion 443-369
30. Ritchie CW, Bush AI, Mackinnon A, Macfarlane S, Mastwyk M, et al. (2003). Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 60: 1685-1691.
31. Bincoletto C, Bechara A, Pereira GJ, Santos CP, Antunes F, et al. (2013). Interplay between apoptosis and autophagy, a challenging puzzle: New perspectives on antitumor chemotherapies. Chem Biol Interact 206: 279-288.