메뉴 건너뛰기




Volumn 2, Issue 3, 2013, Pages 315-321

Concurrent whole brain radiotherapy and short-course chloroquine in patients with brain metastases: A pilot trial

Author keywords

Brain metastases; Chloroquine; Immunomodulation; Immunotherapy; Indoleamine 2,3 dioxygenase (Ido); Non small cell lung cancer (Nsclc); Whole brain radiotherapy

Indexed keywords

CHLOROQUINE; INDOLEAMINE 2, 3 DIOXYGENASE; UNCLASSIFIED DRUG;

EID: 84907922428     PISSN: 19487894     EISSN: 19487908     Source Type: Journal    
DOI: 10.1007/s13566-013-0111-x     Document Type: Article
Times cited : (54)

References (39)
  • 1
    • 27644546807 scopus 로고    scopus 로고
    • Brain metastases: epidemiology and pathophysiology
    • Gavrilovic IT, Posner JB (2005) Brain metastases: epidemiology and pathophysiology. J Neurooncol 75(1): 5-14.
    • (2005) J Neurooncol , vol.75 , Issue.1 , pp. 5-14
    • Gavrilovic, I.T.1    Posner, J.B.2
  • 2
    • 0023885240 scopus 로고
    • Distribution of brain metastases
    • Delattre JY et al (1988) Distribution of brain metastases. Arch Neurol 45(7): 741-744.
    • (1988) Arch Neurol , vol.45 , Issue.7 , pp. 741-744
    • Delattre, J.Y.1
  • 3
    • 0029740191 scopus 로고    scopus 로고
    • Brain metastases. Histology, multiplicity, surgery, and survival
    • Nussbaum ES et al (1996) Brain metastases. Histology, multiplicity, surgery, and survival. Cancer 78(8): 1781-1788.
    • (1996) Cancer , vol.78 , Issue.8 , pp. 1781-1788
    • Nussbaum, E.S.1
  • 4
    • 0018042463 scopus 로고
    • Neurologic complications of systemic cancer
    • Posner JB (1978) Neurologic complications of systemic cancer. Dis Mon 25(2): 1-60.
    • (1978) Dis Mon , vol.25 , Issue.2 , pp. 1-60
    • Posner, J.B.1
  • 5
    • 70449723680 scopus 로고    scopus 로고
    • American College of Radiology appropriateness criteria on multiple brain metastases
    • Videtic GM et al (2009) American College of Radiology appropriateness criteria on multiple brain metastases. Int J Radiat Oncol Biol Phys 75(4): 961-965.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.4 , pp. 961-965
    • Videtic, G.M.1
  • 6
    • 0033054670 scopus 로고    scopus 로고
    • Identification of prognostic factors in patients with brain metastases: a review of 1,292 patients
    • Lagerwaard FJ et al (1999) Identification of prognostic factors in patients with brain metastases: a review of 1, 292 patients. Int J Radiat Oncol Biol Phys 43(4): 795-803.
    • (1999) Int J Radiat Oncol Biol Phys , vol.43 , Issue.4 , pp. 795-803
    • Lagerwaard, F.J.1
  • 7
    • 0036039782 scopus 로고    scopus 로고
    • Long-term survival in patients with brain metastases
    • Lutterbach J, Bartelt S, Ostertag C (2002) Long-term survival in patients with brain metastases. J Cancer Res Clin Oncol 128(8): 417-425.
    • (2002) J Cancer Res Clin Oncol , vol.128 , Issue.8 , pp. 417-425
    • Lutterbach, J.1    Bartelt, S.2    Ostertag, C.3
  • 8
    • 0030973660 scopus 로고    scopus 로고
    • Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials
    • Gaspar L et al (1997) Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys 37(4): 745-751.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , Issue.4 , pp. 745-751
    • Gaspar, L.1
  • 9
    • 58949096573 scopus 로고    scopus 로고
    • A validation study of a new prognostic index for patients with brain metastases: the Graded Prognostic Assessment
    • Sperduto CM et al (2008) A validation study of a new prognostic index for patients with brain metastases: the Graded Prognostic Assessment. J Neurosurg 109(Suppl): 87-89.
    • (2008) J Neurosurg , vol.109 , Issue.SUPPL. , pp. 87-89
    • Sperduto, C.M.1
  • 10
    • 77952567992 scopus 로고    scopus 로고
    • Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients
    • Sperduto PW et al (2010) Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4, 259 patients. Int J Radiat Oncol Biol Phys 77(3): 655-661.
    • (2010) Int J Radiat Oncol Biol Phys , vol.77 , Issue.3 , pp. 655-661
    • Sperduto, P.W.1
  • 11
    • 77954653486 scopus 로고    scopus 로고
    • Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells
    • Kim EL et al (2010) Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro Oncol 12(4): 389-400.
    • (2010) Neuro Oncol , vol.12 , Issue.4 , pp. 389-400
    • Kim, E.L.1
  • 12
    • 33847685719 scopus 로고    scopus 로고
    • Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme
    • Briceno E, Calderon A, Sotelo J (2007) Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme. Surg Neurol 67(4): 388-391.
    • (2007) Surg Neurol , vol.67 , Issue.4 , pp. 388-391
    • Briceno, E.1    Calderon, A.2    Sotelo, J.3
  • 13
    • 33645115547 scopus 로고    scopus 로고
    • Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial
    • Sotelo J, Briceno E, Lopez-Gonzalez MA (2006) Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 144(5): 337-343.
    • (2006) Ann Intern Med , vol.144 , Issue.5 , pp. 337-343
    • Sotelo, J.1    Briceno, E.2    Lopez-Gonzalez, M.A.3
  • 14
    • 33846689594 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses
    • Hou DY et al (2007) Inhibition of indoleamine 2, 3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res 67(2): 792-801.
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 792-801
    • Hou, D.Y.1
  • 15
    • 34547643025 scopus 로고    scopus 로고
    • Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor IDO inhibitory compound D-1MT
    • Metz R et al (2007) Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor IDO inhibitory compound D-1MT. Cancer Res 67: 7082-7087.
    • (2007) Cancer Res , vol.67 , pp. 7082-7087
    • Metz, R.1
  • 16
    • 41149132390 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    • Katz JB et al (2008) Indoleamine 2, 3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev 222: 206-221.
    • (2008) Immunol Rev , vol.222 , pp. 206-221
    • Katz, J.B.1
  • 17
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    • Munn DH, Mellor AL (2007) Indoleamine 2, 3-dioxygenase and tumor-induced tolerance. J Clin Invest 117(5): 1147-1154.
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 18
    • 84866242667 scopus 로고    scopus 로고
    • IDO Is a nodal pathogenic driver of lung cancer and metastasis development
    • Smith C et al (2012) IDO Is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov 2(8): 722-735.
    • (2012) Cancer Discov , vol.2 , Issue.8 , pp. 722-735
    • Smith, C.1
  • 19
    • 2442713678 scopus 로고    scopus 로고
    • Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    • Andrews DW et al (2004) Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 363(9422): 1665-1672.
    • (2004) Lancet , vol.363 , Issue.9422 , pp. 1665-1672
    • Andrews, D.W.1
  • 20
    • 0032873920 scopus 로고    scopus 로고
    • Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases
    • Kondziolka D et al (1999) Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 45(2): 427-434.
    • (1999) Int J Radiat Oncol Biol Phys , vol.45 , Issue.2 , pp. 427-434
    • Kondziolka, D.1
  • 21
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
    • Eisenhauer EA et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1. 1). Eur J Cancer 45(2): 228-247.
    • (2009) Eur J Cancer , vol.45 , Issue.2 , pp. 228-247
    • Eisenhauer, E.A.1
  • 22
    • 84862226725 scopus 로고    scopus 로고
    • Hydroxychloroquine: from malaria to autoimmunity
    • Ben-Zvi I et al (2012) Hydroxychloroquine: from malaria to autoimmunity. Clin Rev Allergy Immunol 42(2): 145-153.
    • (2012) Clin Rev Allergy Immunol , vol.42 , Issue.2 , pp. 145-153
    • Ben-Zvi, I.1
  • 23
    • 38349167878 scopus 로고    scopus 로고
    • Unusual intensification of skin reactions by chloroquine use during breast radiotherapy
    • Munshi A et al (2008) Unusual intensification of skin reactions by chloroquine use during breast radiotherapy. Acta Oncol 47(2): 318-319.
    • (2008) Acta Oncol , vol.47 , Issue.2 , pp. 318-319
    • Munshi, A.1
  • 24
    • 33745228449 scopus 로고    scopus 로고
    • Unexpected skin reaction induced by radiotherapy after chloroquine use
    • Rustogi A, Munshi A, Jalali R (2006) Unexpected skin reaction induced by radiotherapy after chloroquine use. Lancet Oncol 7(7): 608-609.
    • (2006) Lancet Oncol , vol.7 , Issue.7 , pp. 608-609
    • Rustogi, A.1    Munshi, A.2    Jalali, R.3
  • 25
    • 0019809752 scopus 로고
    • Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group
    • Borgelt B et al (1981) Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 7(12): 1633-1638.
    • (1981) Int J Radiat Oncol Biol Phys , vol.7 , Issue.12 , pp. 1633-1638
    • Borgelt, B.1
  • 26
    • 49149101813 scopus 로고    scopus 로고
    • A phase III study of accelerated versus conventional hypofractionated whole brain irradiation in patients of good performance status with brain metastases not suitable for surgical excision
    • Davey P et al (2008) A phase III study of accelerated versus conventional hypofractionated whole brain irradiation in patients of good performance status with brain metastases not suitable for surgical excision. Radiother Oncol 88(2): 173-176.
    • (2008) Radiother Oncol , vol.88 , Issue.2 , pp. 173-176
    • Davey, P.1
  • 27
    • 0027518924 scopus 로고
    • Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases
    • Haie-Meder C et al (1993) Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol 26(2): 111-116.
    • (1993) Radiother Oncol , vol.26 , Issue.2 , pp. 111-116
    • Haie-Meder, C.1
  • 28
    • 18744420820 scopus 로고    scopus 로고
    • A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: a report of the Radiation Therapy Oncology Group (RTOG) 9104
    • Murray KJ et al (1997) A randomized phase III study of accelerated hyperfractionation versus standard in patients with unresected brain metastases: a report of the Radiation Therapy Oncology Group (RTOG) 9104. Int J Radiat Oncol Biol Phys 39(3): 571-574.
    • (1997) Int J Radiat Oncol Biol Phys , vol.39 , Issue.3 , pp. 571-574
    • Murray, K.J.1
  • 29
    • 0036731532 scopus 로고    scopus 로고
    • Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases
    • Antonadou D et al (2002) Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J Clin Oncol 20(17): 3644-3650.
    • (2002) J Clin Oncol , vol.20 , Issue.17 , pp. 3644-3650
    • Antonadou, D.1
  • 30
    • 0024325795 scopus 로고
    • The combined use of radiation therapy and lonidamine in the treatment of brain metastases
    • DeAngelis LM et al (1989) The combined use of radiation therapy and lonidamine in the treatment of brain metastases. J Neurooncol 7(3): 241-247.
    • (1989) J Neurooncol , vol.7 , Issue.3 , pp. 241-247
    • DeAngelis, L.M.1
  • 31
    • 0021702452 scopus 로고
    • Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain
    • Eyre HJ et al (1984) Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study J Neurooncol 2(4): 325-330.
    • (1984) A Southwest Oncology Group Study. J Neurooncol , vol.2 , Issue.4 , pp. 325-330
    • Eyre, H.J.1
  • 32
    • 0025969535 scopus 로고
    • A randomized phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916)
    • Komarnicky LT et al (1991) A randomized phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916). Int J Radiat Oncol Biol Phys 20(1): 53-58.
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , Issue.1 , pp. 53-58
    • Komarnicky, L.T.1
  • 33
    • 0029114147 scopus 로고
    • Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: report of RTOG trial 89-05
    • Phillips TL et al (1995) Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: report of RTOG trial 89-05. Int J Radiat Oncol Biol Phys 33(2): 339-348.
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , Issue.2 , pp. 339-348
    • Phillips, T.L.1
  • 34
    • 61549104698 scopus 로고    scopus 로고
    • Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial
    • Mehta MP et al (2009) Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial. Int J Radiat Oncol Biol Phys 73(4): 1069-1076.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , Issue.4 , pp. 1069-1076
    • Mehta, M.P.1
  • 35
    • 37349077910 scopus 로고    scopus 로고
    • Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases
    • Scott C et al (2007) Improved survival, quality of life, and quality-adjusted survival in breast cancer patients treated with efaproxiral (Efaproxyn) plus whole-brain radiation therapy for brain metastases. Am J Clin Oncol 30(6): 580-587.
    • (2007) Am J Clin Oncol , vol.30 , Issue.6 , pp. 580-587
    • Scott, C.1
  • 36
    • 33644499236 scopus 로고    scopus 로고
    • Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases
    • Suh JH et al (2006) Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases. J Clin Oncol 24(1): 106-114.
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 106-114
    • Suh, J.H.1
  • 37
    • 0000191348 scopus 로고    scopus 로고
    • DNA topoisomerase II rescue by catalytic inhibitors: a new strategy to improve the antitumor selectivity of etoposide
    • Jensen PB, Sehested M (1997) DNA topoisomerase II rescue by catalytic inhibitors: a new strategy to improve the antitumor selectivity of etoposide. Biochem Pharmacol 54(7): 755-759.
    • (1997) Biochem Pharmacol , vol.54 , Issue.7 , pp. 755-759
    • Jensen, P.B.1    Sehested, M.2
  • 38
    • 0030867351 scopus 로고    scopus 로고
    • pH-dependent regulation of camptothecin-induced cytotoxicity and cleavable complex formation by the antimalarial agent chloroquine
    • Sorensen M, Sehested M, Jensen PB (1997) pH-dependent regulation of camptothecin-induced cytotoxicity and cleavable complex formation by the antimalarial agent chloroquine. Biochem Pharmacol 54(3): 373-380.
    • (1997) Biochem Pharmacol , vol.54 , Issue.3 , pp. 373-380
    • Sorensen, M.1    Sehested, M.2    Jensen, P.B.3
  • 39
    • 79951847989 scopus 로고    scopus 로고
    • Principles and current strategies for targeting autophagy for cancer treatment
    • Amaravadi RK et al (2011) Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 17(4): 654-666.
    • (2011) Clin Cancer Res , vol.17 , Issue.4 , pp. 654-666
    • Amaravadi, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.