Acetylation-defective mutants of Pparγ are associated with decreased lipid synthesis in breast cancer cells

Oncotarget

Volumn 5, Issue 17, 2014, Pages 7303-7315

  Tian, Lifeng ^a   Wang, Chenguang ^a   Hagen, Fred K ^b   Gormley, Michael ^a   Addya, Sankar ^a   Soccio, Raymond ^c   Casimiro, Mathew C ^a   Zhou, Jie ^a   Powell, Michael J ^a   Xu, Ping ^d   Deng, Haiteng ^e   Sauve, Anthony A ^d   Pestell, Richard G ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Acetylation; Lipogenesis; Nuclear receptors; Peroxisome proliferator activated receptor gamma (Ppar ); Silent mating type information regulation 2 homolog 1 (SIRT1)

Indexed keywords

CYCLIN D1; CYCLIN E; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 1; SIRTUIN 1; UNCLASSIFIED DRUG; SIRT1 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BREAST CANCER CELL LINE; CELL LABELING; DEACETYLATION; DELETION MUTANT; GAIN OF FUNCTION MUTATION; GENE CONTROL; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIPOGENESIS; MASS SPECTROMETRY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROTEIN ACETYLATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; ACETYLATION; ANIMAL; BREAST TUMOR; CELL AGING; CONSERVED SEQUENCE; DNA MICROARRAY; GENETIC TRANSFECTION; HUMAN; IMMUNOPRECIPITATION; LIPID METABOLISM; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE; WESTERN BLOTTING;

ACETYLATION; AMINO ACID MOTIFS; ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL AGING; CELL LINE, TUMOR; CONSERVED SEQUENCE; HUMANS; IMMUNOPRECIPITATION; LIPID METABOLISM; MASS SPECTROMETRY; MICE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PPAR GAMMA; PROTEIN STRUCTURE, TERTIARY; SIRTUIN 1; TRANSFECTION;

EID: 84907501117     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2371     Document Type: Article

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