Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization

Journal of Clinical Investigation

Volumn 124, Issue 10, 2014, Pages 4335-4350

  Magrini, Elena ^a   Villa, Alessandra ^a   Angiolini, Francesca ^a   Doni, Andrea ^b   Mazzarol, Giovanni ^a   Rudini, Noemi ^c   Maddaluno, Luigi ^c   Komuta, Mina ^d   Topal, Baki ^d   Prenen, Hans ^d   Schachner, Melitta ^e   Confalonieri, Stefano ^a   Dejana, Elisabetta ^c   Bianchi, Fabrizio ^a   Mazzone, Massimiliano ^f,g   Cavallaro, Ugo ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^e RUTGERS UNIVERSITY   (United States)

^f DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^g UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALVASCULIN; COLLAGEN TYPE 4; FIBRONECTIN; INHIBITOR OF DIFFERENTIATION 1; INTERLEUKIN 6; JANUS KINASE; KRUPPEL LIKE FACTOR 4; NERVE CELL ADHESION MOLECULE L1; STAT3 PROTEIN; TRANSCRIPTOME; VIMENTIN; ANGIOPOIETIN RECEPTOR; STAT3 PROTEIN, MOUSE; TEK PROTEIN, MOUSE;

ANGIOGENESIS; ANGIOGENESIS ASSAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY DENSITY; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIAL MESENCHYMAL TRANSITION; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; METASTASIS; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOPHYSIOLOGY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR VASCULARIZATION; UPREGULATION; VASCULAR TUMOR; ANIMAL; BLOOD VESSEL; C57BL MOUSE; CAPILLARY PERMEABILITY; CARCINOMA; CELL MOTION; CYTOLOGY; FEMALE; GENETICS; HEMANGIOMA; HUMAN; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOLOGY; PERMEABILITY; PHENOTYPE; PHYSIOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; BLOOD VESSELS; CAPILLARY PERMEABILITY; CARCINOMA; CELL MOVEMENT; CELL PROLIFERATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; HEMANGIOMA; HUMANS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, TRANSGENIC; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEURAL CELL ADHESION MOLECULE L1; PANCREATIC NEOPLASMS; PERMEABILITY; PHENOTYPE; RECEPTOR, TIE-2; RNA INTERFERENCE; STAT3 TRANSCRIPTION FACTOR;

EID: 84907494623     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI70683     Document Type: Article

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