-
1
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov, S.I. et al. (2010) Immunity, inflammation, and cancer. Cell, 140, 883-899.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
-
2
-
-
33749024777
-
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
-
Christiansen, J.J. et al. (2006) Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res., 66, 8319-8326.
-
(2006)
Cancer Res
, vol.66
, pp. 8319-8326
-
-
Christiansen, J.J.1
-
3
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
-
Polyak, K. et al. (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer, 9, 265-273.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 265-273
-
-
Polyak, K.1
-
4
-
-
33947192053
-
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
-
Cheng, G.Z. et al. (2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res., 67, 1979-1987.
-
(2007)
Cancer Res
, vol.67
, pp. 1979-1987
-
-
Cheng, G.Z.1
-
5
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery, J.P. (2002) Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer, 2, 442-454.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
6
-
-
67650999217
-
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
-
Arumugam, T. et al. (2009) Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res., 69, 5820-5828.
-
(2009)
Cancer Res
, vol.69
, pp. 5820-5828
-
-
Arumugam, T.1
-
7
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery, J.P. et al. (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol., 7, 131-142.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
-
8
-
-
42749091317
-
Epithelial-mesenchymal transition and the invasive potential of tumors
-
Gavert, N. et al. (2008) Epithelial-mesenchymal transition and the invasive potential of tumors. Trends Mol. Med., 14, 199-209.
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 199-209
-
-
Gavert, N.1
-
9
-
-
24644487312
-
TGF-beta and epithelial-to-mesenchymal transitions
-
Zavadil, J. et al. (2005) TGF-beta and epithelial-to-mesenchymal transitions. Oncogene, 24, 5764-5774.
-
(2005)
Oncogene
, vol.24
, pp. 5764-5774
-
-
Zavadil, J.1
-
10
-
-
35148832569
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
-
Lo, H.W. et al. (2007) Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res., 67, 9066-9076.
-
(2007)
Cancer Res
, vol.67
, pp. 9066-9076
-
-
Lo, H.W.1
-
11
-
-
36549010842
-
Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
-
Leong, K.G. et al. (2007) Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med., 204, 2935-2948.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2935-2948
-
-
Leong, K.G.1
-
12
-
-
77949801978
-
Up-regulation of L1CAM is linked to loss of hormone receptors and E-cadherin in aggressive subtypes of endometrial carcinomas
-
Huszar, M. et al. (2010) Up-regulation of L1CAM is linked to loss of hormone receptors and E-cadherin in aggressive subtypes of endometrial carcinomas. J. Pathol., 220, 551-561.
-
(2010)
J. Pathol.
, vol.220
, pp. 551-561
-
-
Huszar, M.1
-
13
-
-
66249104020
-
Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer
-
Geismann, C. et al. (2009) Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer. Cancer Res., 69, 4517-4526.
-
(2009)
Cancer Res
, vol.69
, pp. 4517-4526
-
-
Geismann, C.1
-
14
-
-
0023805739
-
Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin
-
Moos, M. et al. (1988) Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin. Nature, 334, 701-703.
-
(1988)
Nature
, vol.334
, pp. 701-703
-
-
Moos, M.1
-
15
-
-
0038405181
-
Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations
-
Brummendorf, T. et al. (1998) Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations. Curr. Opin. Neurobiol., 8, 87-97.
-
(1998)
Curr. Opin. Neurobiol.
, vol.8
, pp. 87-97
-
-
Brummendorf, T.1
-
16
-
-
0030847316
-
Neural recognition molecules and synaptic plasticity
-
Schachner, M. (1997) Neural recognition molecules and synaptic plasticity. Curr. Opin. Cell Biol., 9, 627-634.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 627-634
-
-
Schachner, M.1
-
17
-
-
77954586994
-
L1CAM malfunction in the nervous system and human carcinomas
-
Schafer, M.K. et al. (2010) L1CAM malfunction in the nervous system and human carcinomas. Cell Mol. Life Sci., 67, 2425-2437.
-
(2010)
Cell Mol. Life Sci.
, vol.67
, pp. 2425-2437
-
-
Schafer, M.K.1
-
18
-
-
56249120989
-
L1-CAM in cancerous tissues
-
Gavert, N. et al. (2008) L1-CAM in cancerous tissues. Expert Opin. Biol. Ther., 8, 1749-1757.
-
(2008)
Expert Opin. Biol. Ther.
, vol.8
, pp. 1749-1757
-
-
Gavert, N.1
-
19
-
-
0033621478
-
Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
-
Schaefer, A.W. et al. (1999) Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization. J. Biol. Chem., 274, 37965-37973.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37965-37973
-
-
Schaefer, A.W.1
-
20
-
-
3142733866
-
Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion
-
Silletti, S. et al. (2004) Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J. Biol. Chem., 279, 28880-28888.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 28880-28888
-
-
Silletti, S.1
-
21
-
-
13944268218
-
L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
-
Gavert, N. et al. (2005) L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol., 168, 633-642.
-
(2005)
J. Cell Biol.
, vol.168
, pp. 633-642
-
-
Gavert, N.1
-
22
-
-
39749174412
-
The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies
-
Gast, D. et al. (2008) The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies. Oncogene, 27, 1281-1289.
-
(2008)
Oncogene
, vol.27
, pp. 1281-1289
-
-
Gast, D.1
-
23
-
-
66949155975
-
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
-
Riedle, S. et al. (2009) Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity. Biochem. J., 420, 391-402.
-
(2009)
Biochem. J.
, vol.420
, pp. 391-402
-
-
Riedle, S.1
-
24
-
-
77956178436
-
L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression
-
Kiefel, H. et al. (2010) L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression. Oncogene, 29, 4766-4778.
-
(2010)
Oncogene
, vol.29
, pp. 4766-4778
-
-
Kiefel, H.1
-
25
-
-
79954599102
-
Linking L1CAM-mediated signaling to NF-kappaB activation
-
Kiefel, H. et al. (2011) Linking L1CAM-mediated signaling to NF-kappaB activation. Trends Mol. Med., 17, 178-187.
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 178-187
-
-
Kiefel, H.1
-
26
-
-
77953566942
-
Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells
-
Gavert, N. et al. (2010) Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells. J. Cell Sci., 123, 2135-2143.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 2135-2143
-
-
Gavert, N.1
-
27
-
-
0035969235
-
Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins
-
Mechtersheimer, S. et al. (2001) Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J. Cell Biol., 155, 661-673.
-
(2001)
J. Cell Biol.
, vol.155
, pp. 661-673
-
-
Mechtersheimer, S.1
-
28
-
-
0027404269
-
p53 and K-RAS alterations in pancreatic epithelial cell lesions
-
Kalthoff, H. et al. (1993) p53 and K-RAS alterations in pancreatic epithelial cell lesions. Oncogene, 8, 289-298.
-
(1993)
Oncogene
, vol.8
, pp. 289-298
-
-
Kalthoff, H.1
-
29
-
-
34247483148
-
Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells
-
Sebens Muerkoster, S. et al. (2007) Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells. Oncogene, 26, 2759-2768.
-
(2007)
Oncogene
, vol.26
, pp. 2759-2768
-
-
Sebens Muerkoster, S.1
-
30
-
-
77954541163
-
TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5
-
Lemke, J. et al. (2010) TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5. J. Mol. Med., 88, 729-740.
-
(2010)
J. Mol. Med.
, vol.88
, pp. 729-740
-
-
Lemke, J.1
-
31
-
-
84865161157
-
CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer
-
Marme, F. et al. (2012) CD24 Ala57Val polymorphism predicts pathologic complete response to sequential anthracycline- and taxane-based neoadjuvant chemotherapy for primary breast cancer. Breast Cancer Res. Treat., 132, 819-831.
-
(2012)
Breast Cancer Res. Treat.
, vol.132
, pp. 819-831
-
-
Marme, F.1
-
32
-
-
0034686024
-
Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells
-
Gutwein, P. et al. (2000) Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells. J. Biol. Chem., 275, 15490-15497.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15490-15497
-
-
Gutwein, P.1
-
33
-
-
57849107999
-
Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration
-
Issa, Y. et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J. Mol. Med., 87, 99-112.
-
(2009)
J. Mol. Med.
, vol.87
, pp. 99-112
-
-
Issa, Y.1
-
34
-
-
77955942231
-
L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions
-
Pfeifer, M. et al. (2010) L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions. BMC Mol. Biol., 11, 64.
-
(2010)
BMC Mol. Biol.
, vol.11
, pp. 64
-
-
Pfeifer, M.1
-
35
-
-
84864315091
-
Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NF(B activation
-
Bondong, B. et al. (2011) Prognostic significance of L1CAM in ovarian cancer and its role in constitutive NFκB activation. Ann Oncol. 2012; 23(7):1795-802.
-
(2011)
Ann Oncol. 2012
, vol.23
, Issue.7
, pp. 1795-1802
-
-
Bondong, B.1
-
36
-
-
0031817380
-
Sulfated glycosaminoglycans enhance tumor cell invasion in vitro by stimulating plasminogen activation
-
Brunner, G. et al. (1998) Sulfated glycosaminoglycans enhance tumor cell invasion in vitro by stimulating plasminogen activation. Exp. Cell Res., 239, 301-310.
-
(1998)
Exp. Cell Res.
, vol.239
, pp. 301-310
-
-
Brunner, G.1
-
37
-
-
0038621384
-
Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
-
Arlt, A. et al. (2003) Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene, 22, 3243-3251.
-
(2003)
Oncogene
, vol.22
, pp. 3243-3251
-
-
Arlt, A.1
-
38
-
-
13944252061
-
Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells
-
Muerkoster, S. et al. (2005) Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells. Cancer Res., 65, 1316-1324.
-
(2005)
Cancer Res
, vol.65
, pp. 1316-1324
-
-
Muerkoster, S.1
-
39
-
-
0035861541
-
Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
-
Bhowmick, N.A. et al. (2001) Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity.J. Biol. Chem., 276, 46707-46713.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46707-46713
-
-
Bhowmick, N.A.1
-
40
-
-
84857613435
-
aV integrins and TGF-β-induced EMT: a circle of regulation
-
Mamuya, F.A. et al. (2012) aV integrins and TGF-β-induced EMT: a circle of regulation. J. Cell Mol. Med., 16, 445-455.
-
(2012)
J. Cell Mol. Med.
, vol.16
, pp. 445-455
-
-
Mamuya, F.A.1
-
41
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo, W. et al. (2004) Integrin signalling during tumour progression. Nat. Rev. Mol. Cell Biol., 5, 816-826.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 816-826
-
-
Guo, W.1
-
43
-
-
75949103899
-
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
-
Margadant, C. et al. (2010) Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep., 11, 97-105.
-
(2010)
EMBO Rep
, vol.11
, pp. 97-105
-
-
Margadant, C.1
-
44
-
-
20844462570
-
L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas
-
Gast, D. et al. (2005) L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas. Int. J. Cancer, 115, 658-665.
-
(2005)
Int. J. Cancer
, vol.115
, pp. 658-665
-
-
Gast, D.1
-
45
-
-
80053615174
-
L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
-
Tischler, V. et al. (2011) L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer. Mol. Cancer, 10, 127.
-
(2011)
Mol. Cancer
, vol.10
, pp. 127
-
-
Tischler, V.1
-
46
-
-
47549089465
-
The RGD integrin binding site in human L1-CAM is important for nuclear signaling
-
Gast, D. et al. (2008) The RGD integrin binding site in human L1-CAM is important for nuclear signaling. Exp. Cell Res., 314, 2411-2418.
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 2411-2418
-
-
Gast, D.1
-
47
-
-
33846558132
-
L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells
-
Stoeck, A. et al. (2007) L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol. Oncol., 104, 461-469.
-
(2007)
Gynecol. Oncol.
, vol.104
, pp. 461-469
-
-
Stoeck, A.1
-
48
-
-
77954711918
-
L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma
-
Min, J.K. et al. (2010) L1 cell adhesion molecule is a novel therapeutic target in intrahepatic cholangiocarcinoma. Clin. Cancer Res., 16, 3571-3580.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3571-3580
-
-
Min, J.K.1
-
49
-
-
82955169603
-
L1 stimulation of human glioma cell motility correlates with FAK activation
-
Yang, M. et al. (2011) L1 stimulation of human glioma cell motility correlates with FAK activation. J. Neurooncol., 105, 27-44.
-
(2011)
J. Neurooncol.
, vol.105
, pp. 27-44
-
-
Yang, M.1
-
50
-
-
77951096447
-
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
-
Guan, J.L. (2010) Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life, 62, 268-276.
-
(2010)
IUBMB Life
, vol.62
, pp. 268-276
-
-
Guan, J.L.1
-
51
-
-
12144267589
-
L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region
-
Cheng, L. et al. (2005) L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region. J. Neurosci., 25, 395-403.
-
(2005)
J. Neurosci.
, vol.25
, pp. 395-403
-
-
Cheng, L.1
-
52
-
-
4344612243
-
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
-
Huber, M.A. et al. (2004) NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest., 114, 569-581.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 569-581
-
-
Huber, M.A.1
-
53
-
-
34548015630
-
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
-
Gavert, N. et al. (2007) Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res., 67, 7703-7712.
-
(2007)
Cancer Res
, vol.67
, pp. 7703-7712
-
-
Gavert, N.1
-
54
-
-
33745478818
-
The adhesion molecule L1 (CD171) promotes melanoma progression
-
Meier, F. et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int. J. Cancer, 119, 549-555.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 549-555
-
-
Meier, F.1
-
55
-
-
0037096430
-
The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins
-
Thelen, K. et al. (2002) The neural cell adhesion molecule L1 potentiates integrin-dependent cell migration to extracellular matrix proteins. J. Neurosci., 22, 4918-4931.
-
(2002)
J. Neurosci.
, vol.22
, pp. 4918-4931
-
-
Thelen, K.1
|