Homeodomain-containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue

FEBS Journal

Volumn 279, Issue 19, 2012, Pages 3715-3726

  Shrestha, Bishakha ^a   Ansari, Khairul I ^a   Bhan, Arunoday ^a   Kasiri, Sahba ^a   Hussain, Imran ^a   Mandal, Subhrangsu S ^a  

^a UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

breast cancer; colony formation; gene regulation; HOXB9; tumor growth

Indexed keywords

ANGIOGENIC FACTOR; ESTROGEN; FIBROBLAST GROWTH FACTOR 2; HOMEODOMAIN PROTEIN; NEU DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXB9; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE PROGRESSION; CHROMATIN IMMUNOPRECIPITATION; COLONY FORMATION; CONTROLLED STUDY; EMBRYO; FLUORESCENCE MICROSCOPY; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSCRIPTION REGULATION; TUMOR GROWTH; UPREGULATION;

ANGIOGENESIS INDUCING AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; COLONY-FORMING UNITS ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE ARRAY ANALYSIS;

EID: 84866412395     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08733.x     Document Type: Article

References (46)

1. Zakany J, &, Duboule D, (2007) The role of Hox genes during vertebrate limb development. Curr Opin Genet Dev 17, 359-366. (Pubitemid 47241269)
2. Lappin TR, Grier DG, Thompson A, &, Halliday HL, (2006) HOX genes: seductive science, mysterious mechanisms. Ulster Med J 75, 23-31. (Pubitemid 43168878)
3. Grier DG, Thompson A, Kwasniewska A, McGonigle GJ, Halliday HL, &, Lappin TR, (2005) The pathophysiology of HOX genes and their role in cancer. J Pathol 205, 154-171. (Pubitemid 40227988)
4. Alexander T, Nolte C, &, Krumlauf R, (2009) Hox genes and segmentation of the hindbrain and axial skeleton. Annu Rev Cell Dev Biol 25, 431-456.
5. Hejnol A, &, Martindale MQ, (2009) Coordinated spatial and temporal expression of Hox genes during embryogenesis in the acoel Convolutriloba longifissura. BMC Biol 7, 65.
6. Krumlauf R, (1994) Hox genes in vertebrate development. Cell 78, 191-201. (Pubitemid 24241088)
7. Coulombe Y, Lemieux M, Moreau J, Aubin J, Joksimovic M, Berube-Simard FA, Tabaries S, Boucherat O, Guillou F, Larochelle C, et al,. (2010) Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo. PLoS One 5, e10600.
8. Chen H, &, Sukumar S, (2003) Role of homeobox genes in normal mammary gland development and breast tumorigenesis. J Mammary Gland Biol Neoplasia 8, 159-175. (Pubitemid 38129939)
9. Rubin MR, King W, Toth LE, Sawczuk IS, Levine MS, D'Eustachio P, &, Nguyen-Huu MC, (1987) Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression. Mol Cell Biol 7, 3836-3841.
10. Shen WF, Chang CP, Rozenfeld S, Sauvageau G, Humphries RK, Lu M, Lawrence HJ, Cleary ML, &, Largman C, (1996) Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Nucleic Acids Res 24, 898-906.
11. Chen CY, &, Schwartz RJ, (1995) Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J Biol Chem 270, 15628-15633.
12. Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, &, Kamps MP, (1999) A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1. Nucleic Acids Res 27, 3752-3761. (Pubitemid 29435757)
13. Mann RS, &, Chan SK, (1996) Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins. Trends Genet 12, 258-262.
14. Shen WF, Krishnan K, Lawrence HJ, &, Largman C, (2001) The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol 21, 7509-7522. (Pubitemid 32953500)
15. Ansari KI, Hussain I, Kasiri S, &, Mandal SS, (2012) HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4. J Mol Endocrinol 48, 61-75.
16. Chen H, &, Sukumar S, (2003) HOX genes: emerging stars in cancer. Cancer Biol Ther 2, 524-525.
17. Amalinei C, (2007) Morphogenesis and differentiation of the female genital tract. Genetic determinism and epithelium-stromal interactions. Rev Med Chir Soc Med Nat Iasi 111, 200-209.
18. Winnik S, Klinkert M, Kurz H, Zoeller C, Heinke J, Wu Y, Bode C, Patterson C, &, Moser M, (2009) HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2. Cardiovasc Res 83, 558-565.
19. McGonigle GJ, Lappin TR, &, Thompson A, (2008) Grappling with the HOX network in hematopoiesis and leukemia. Front Biosci 13, 4297-4308. (Pubitemid 351599685)
20. Medina-Martinez O, Bradley A, &, Ramirez-Solis R, (2000) A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. Dev Biol 222, 71-83. (Pubitemid 30387730)
21. Chen F, &, Capecchi MR, (1997) Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions. Dev Biol 181, 186-196. (Pubitemid 27089071)
22. Chen F, Greer J, &, Capecchi MR, (1998) Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Mech Dev 77, 49-57. (Pubitemid 28508983)
23. Pan L, Xie Y, Black TA, Jones CA, Pruitt SC, &, Gross KW, (2001) An Abd-B class HOX.PBX recognition sequence is required for expression from the mouse Ren-1c gene. J Biol Chem 276, 32489-32494.
24. Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco MM, Wijendran V, Shioda T, et al,. (2010) HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proc Natl Acad Sci USA 107, 1100-1105.
25. Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, et al,. (2011) Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proc Natl Acad Sci USA 109, 2760-2765.
26. Ansari KI, Shrestha B, Hussain I, Kasiri S, &, Mandal SS, (2011) Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression. Biochemistry, 50, 3517-3527.
27. Dadiani M, Seger D, Kreizman T, Badikhi D, Margalit R, Eilam R, &, Degani H, (2009) Estrogen regulation of vascular endothelial growth factor in breast cancer in vitro and in vivo: the role of estrogen receptor alpha and c-Myc. Endocr Relat Cancer 16, 819-834.
28. Zhang J, Park SI, Artime MC, Summy JM, Shah AN, Bomser JA, Dorfleutner A, Flynn DC, &, Gallick GE, (2007) AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts. J Clin Invest 117, 2962-2973. (Pubitemid 47529626)
29. Ansari KI, Mishra BP, &, Mandal SS, (2008) Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Biochim Biophys Acta 1779, 66-73.
30. Orphanides G, &, Reinberg D, (2002) A unified theory of gene expression. Cell 108, 439-451. (Pubitemid 34260870)
31. Dai J, &, Rabie AB, (2007) VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res 86, 937-950.
32. Advani SH, (2010) Targeting mTOR pathway: a new concept in cancer therapy. Indian J Med Paediatr Oncol 31, 132-136.
33. Ansari KI, &, Mandal SS, (2010) Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. FEBS J 277, 1790-1804.
34. Bannister AJ, Schneider R, &, Kouzarides T, (2002) Histone methylation: dynamic or static? Cell 109, 801-806. (Pubitemid 34785995)
35. Ansari KI, Hussain I, Das HK, &, Mandal SS, (2009) Overexpression of human histone methylase MLL1 upon exposure to a food contaminant mycotoxin, deoxynivalenol. FEBS J 276, 3299-3307.
36. Ansari KI, Hussain I, Shrestha B, Kasiri S, &, Mandal SS, (2011) HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment. J Mol Biol 411, 334-349.
37. Ansari KI, Kasiri S, Hussain I, &, Mandal SS, (2009) Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13. FEBS J 276, 7400-7411.
38. Ansari KI, Mishra BP, &, Mandal SS, (2009) MLL histone methylases in gene expression, hormone signaling and cell cycle. Front Biosci 14, 3483-3495.
39. Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, &, Malfoy B, (1997) Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. FEBS Lett 415, 263-267. (Pubitemid 27451945)
40. Lane DB, Rutherford TJ, &, Taylor HS, (2004) HOXA10 expression in endometrial adenocarcinoma. Tumour Biol 25, 264-269. (Pubitemid 40082329)
41. Chen F, &, Capecchi MR, (1999) Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci USA 96, 541-546. (Pubitemid 29061244)
42. Favaro E, Lord S, Harris AL, &, Buffa FM, (2011) Gene expression and hypoxia in breast cancer. Genome Med 3, 55.
43. Roskoski R Jr, (2007) Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol 62, 179-213. (Pubitemid 46679285)
44. Wendt MK, Smith JA, &, Schiemann WP, (2010) Transforming growth factor-beta-induced epithelial-mesenchymal transition facilitates epidermal growth factor-dependent breast cancer progression. Oncogene 29, 6485-6498.
45. Russell KS, Stern DF, Polverini PJ, &, Bender JR, (1999) Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis. Am J Physiol 277, H2205-H2211. (Pubitemid 30048139)
46. Hedhli N, Dobrucki LW, Kalinowski A, Zhuang ZW, Wu X, Russell RR III, Sinusas AJ, &, Russell KS, (2011) Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis. Cardiovasc Res 93, 516-524.