메뉴 건너뛰기




Volumn 29, Issue 12, 2009, Pages 4919-4931

L1-CAM as a target for treatment of cancer with monoclonal antibodies

Author keywords

Isoforms; L1 CAM; Monoclonal antibodies; Review; Signaling; Tumorigenesis

Indexed keywords

ANTIBODY CONJUGATE; GENISTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CHCE7; MONOCLONAL ANTIBODY CHCE7 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID LU 177; MONOCLONAL ANTIBODY CHCE7 CU 64; MONOCLONAL ANTIBODY CHCE7 CU 67; MONOCLONAL ANTIBODY CHCE7 I 131; MONOCLONAL ANTIBODY CHCE7 LU 177; MONOCLONAL ANTIBODY L1 11A CU 67; NERVE CELL ADHESION MOLECULE L1; NERVE CELL ADHESION MOLECULE L1 ANTIBODY; UNCLASSIFIED DRUG;

EID: 75149178180     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (44)

References (76)
  • 1
    • 2142714017 scopus 로고    scopus 로고
    • Monoclonal antibodies as therapeutic agents for cancer
    • Harris M: Monoclonal antibodies as therapeutic agents for cancer. Lancet Oncol 5: 292-302, 2004.
    • (2004) Lancet Oncol , vol.5 , pp. 292-302
    • Harris, M.1
  • 3
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer: Antibody engineering and manufacture
    • Adams GP and Weiner LM: Monoclonal antibody therapy of cancer: Antibody engineering and manufacture. Nature Biotechnol 23: 1147-1157, 2005.
    • (2005) Nature Biotechnol , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 4
    • 0030273292 scopus 로고    scopus 로고
    • Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily
    • Brümmendorf T and Rathjen FG: Structure/function relationships of axon-associated adhesion receptors of the immunoglobulin superfamily. Curr Opin Neurobiol 6: 584-593, 1996.
    • (1996) Curr Opin Neurobiol , vol.6 , pp. 584-593
    • Brümmendorf, T.1    Rathjen, F.G.2
  • 5
    • 0026235917 scopus 로고
    • Cell adhesion molecules and their subgroups in the nervous system
    • Grumet M: Cell adhesion molecules and their subgroups in the nervous system. Curr Opin Neurobiol 1: 370-376, 1991.
    • (1991) Curr Opin Neurobiol , vol.1 , pp. 370-376
    • Grumet, M.1
  • 6
    • 0033952114 scopus 로고    scopus 로고
    • Structural and functional evolution of the L1 family: Are four adhesion molecules better than one?
    • Hortsch M: Structural and functional evolution of the L1 family: are four adhesion molecules better than one? Mol Cell Neurosci 15: 1-10, 2000.
    • (2000) Mol Cell Neurosci , vol.15 , pp. 1-10
    • Hortsch, M.1
  • 8
    • 0030273263 scopus 로고    scopus 로고
    • The L1 family of neural cell adhesion molecules: Old proteins performing new tricks
    • Hortsch M: The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron 17: 587-593, 1996.
    • (1996) Neuron , vol.17 , pp. 587-593
    • Hortsch, M.1
  • 9
    • 3142692818 scopus 로고    scopus 로고
    • The L1CAM extracellular region: A multi-domain protein with modular and cooperative binding modes
    • Haspel J and Grumet M: The L1CAM extracellular region: a multi-domain protein with modular and cooperative binding modes. Front Biosci 8: s1210-1225, 2003.
    • (2003) Front Biosci , vol.8
    • Haspel, J.1    Grumet, M.2
  • 10
    • 0034088446 scopus 로고    scopus 로고
    • Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily
    • Crossin KL and Krushel LA: Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily. Dev Dyn 218: 260-279, 2000.
    • (2000) Dev Dyn , vol.218 , pp. 260-279
    • Crossin, K.L.1    Krushel, L.A.2
  • 11
    • 0029957549 scopus 로고    scopus 로고
    • Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders
    • Bateman A, Jouet M, MacFarlane J, Du JS, Kenwrick S and Chothia C: Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders. EMBO J 15: 6050-6059, 1996.
    • (1996) EMBO J , vol.15 , pp. 6050-6059
    • Bateman, A.1    Jouet, M.2    MacFarlane, J.3    Du, J.S.4    Kenwrick, S.5    Chothia, C.6
  • 12
    • 0030858735 scopus 로고    scopus 로고
    • CRASH Syndrome: Mutations in L1CAM correlate with severity of the disease
    • Yamasaki M, Thompson P and Lemmon V: CRASH Syndrome: Mutations in L1CAM correlate with severity of the disease. Neuropediatrics 28: 175-178, 1997.
    • (1997) Neuropediatrics , vol.28 , pp. 175-178
    • Yamasaki, M.1    Thompson, P.2    Lemmon, V.3
  • 14
    • 0033564746 scopus 로고    scopus 로고
    • Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice
    • Demyanenko GP, Tsai AY and Maness PF: Abnormalities in neuronal process extension, hippocampal development, and the ventricular system of L1 knockout mice. J Neurosci 19: 4907-4920, 1999.
    • (1999) J Neurosci , vol.19 , pp. 4907-4920
    • Demyanenko, G.P.1    Tsai, A.Y.2    Maness, P.F.3
  • 18
    • 0033822935 scopus 로고    scopus 로고
    • IgCAMs: Bidirectional signals underlying neurite growth
    • Kamiguchi H and Lemmon V: IgCAMs: bidirectional signals underlying neurite growth. Curr Opin Cell Biol 12: 598-605, 2000.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 598-605
    • Kamiguchi, H.1    Lemmon, V.2
  • 20
    • 3142764632 scopus 로고    scopus 로고
    • L1 (CD171) as a novel biomarker for ovarian and endometrial carcinomas
    • Fogel M, Huszar M, Altevogt P and Ben-Arie A: L1 (CD171) as a novel biomarker for ovarian and endometrial carcinomas. Expert Rev Mol Diagn 4: 455-462, 2004.
    • (2004) Expert Rev Mol Diagn , vol.4 , pp. 455-462
    • Fogel, M.1    Huszar, M.2    Altevogt, P.3    Ben-Arie, A.4
  • 23
    • 75149116279 scopus 로고    scopus 로고
    • L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells
    • Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P and Altevogt P: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Clin Cancer Res 11: 7234-7242, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 7234-7242
    • Stoeck, A.1    Gast, D.2    Sanderson, M.P.3    Issa, Y.4    Gutwein, P.5    Altevogt, P.6
  • 27
    • 34249005587 scopus 로고    scopus 로고
    • L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer
    • Boo YJ, Park JM, Kim J, Chae YS, Min BW, Um JW and Moon HY: L1 expression as a marker for poor prognosis, tumor progression, and short survival in patients with colorectal cancer. Ann Surg Oncol 14: 1703-1711, 2007.
    • (2007) Ann Surg Oncol , vol.14 , pp. 1703-1711
    • Boo, Y.J.1    Park, J.M.2    Kim, J.3    Chae, Y.S.4    Min, B.W.5    Um, J.W.6    Moon, H.Y.7
  • 29
    • 13944268218 scopus 로고    scopus 로고
    • L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
    • Gavert N, Conacci-Sorrell M, Gast D, Schneider A, Altevogt P, Brabletz T and Ben-Ze'ev A: L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol 168: 633-642, 2005.
    • (2005) J Cell Biol , vol.168 , pp. 633-642
    • Gavert, N.1    Conacci-Sorrell, M.2    Gast, D.3    Schneider, A.4    Altevogt, P.5    Brabletz, T.6    Ben-Ze'ev, A.7
  • 32
    • 12944259073 scopus 로고    scopus 로고
    • The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas
    • Allory Y, Matsuoka Y, Bazille C, Christensen EI, Ronco P and Debiec H: The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas. Clin Cancer Res 11: 1190-1197, 2005.
    • (2005) Clin Cancer Res , vol.11 , pp. 1190-1197
    • Allory, Y.1    Matsuoka, Y.2    Bazille, C.3    Christensen, E.I.4    Ronco, P.5    Debiec, H.6
  • 33
    • 0038164736 scopus 로고    scopus 로고
    • Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas)
    • Deichmann M, Kurzen H, Egner U, Altevogt P and Hartschuh W: Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas). J Cutan Pathol 30: 363-368, 2003.
    • (2003) J Cutan Pathol , vol.30 , pp. 363-368
    • Deichmann, M.1    Kurzen, H.2    Egner, U.3    Altevogt, P.4    Hartschuh, W.5
  • 35
    • 33746260069 scopus 로고    scopus 로고
    • Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy
    • Huszar M, Moldenhauer G, Gschwend V, Ben-Arie A, Altevogt P and Fogel M: Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum Pathol 37: 1000-1008, 2006.
    • (2006) Hum Pathol , vol.37 , pp. 1000-1008
    • Huszar, M.1    Moldenhauer, G.2    Gschwend, V.3    Ben-Arie, A.4    Altevogt, P.5    Fogel, M.6
  • 36
    • 56249120989 scopus 로고    scopus 로고
    • Gavert N, Ben-Shmuel A, Raveh S and Ben-Ze'ev: L1-CAM in cancerous tissues. Expert Opin Biol Ther 8: 1750-1757, 2008.
    • Gavert N, Ben-Shmuel A, Raveh S and Ben-Ze'ev: L1-CAM in cancerous tissues. Expert Opin Biol Ther 8: 1750-1757, 2008.
  • 38
    • 3142733866 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion
    • Silletti S, Yebra M, Perez B, Cirulli V, McMahon M and Montgomery AM: Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem 279: 28880-28888, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 28880-28888
    • Silletti, S.1    Yebra, M.2    Perez, B.3    Cirulli, V.4    McMahon, M.5    Montgomery, A.M.6
  • 39
    • 33744764926 scopus 로고    scopus 로고
    • MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin-binding site regulates neuronal growth
    • Whittard JD, Sakurai T, Cassella MR, Gazdoiu M, and Felsenfeld DP: MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin-binding site regulates neuronal growth. Mol Biol Cell 17: 2696-2706, 2006.
    • (2006) Mol Biol Cell , vol.17 , pp. 2696-2706
    • Whittard, J.D.1    Sakurai, T.2    Cassella, M.R.3    Gazdoiu, M.4    Felsenfeld, D.P.5
  • 44
    • 33845807351 scopus 로고    scopus 로고
    • Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells
    • Shutman M, Levina E, Ohouo P, Baig M and Roninson IB: Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells. Cancer Res 66: 11370-11380, 2006.
    • (2006) Cancer Res , vol.66 , pp. 11370-11380
    • Shutman, M.1    Levina, E.2    Ohouo, P.3    Baig, M.4    Roninson, I.B.5
  • 45
    • 3843076459 scopus 로고    scopus 로고
    • Hepatocyte growth factor-induced ectodomain shedding of cell adhesion molecule L1: Role of the L1 cytoplasmic domain
    • Heiz M, Grünberg J, Schubiger PA and Novak-Hofer I: Hepatocyte growth factor-induced ectodomain shedding of cell adhesion molecule L1: role of the L1 cytoplasmic domain. J Biol Chem 279: 31149-31156, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 31149-31156
    • Heiz, M.1    Grünberg, J.2    Schubiger, P.A.3    Novak-Hofer, I.4
  • 48
    • 33846558132 scopus 로고    scopus 로고
    • L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cellls
    • Stoeck A, Gast D, Sanderson MP, Issa Y, Gutwein P and Altevogt P: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cellls. Gynecol Oncol 104: 461-469, 2007.
    • (2007) Gynecol Oncol , vol.104 , pp. 461-469
    • Stoeck, A.1    Gast, D.2    Sanderson, M.P.3    Issa, Y.4    Gutwein, P.5    Altevogt, P.6
  • 50
    • 15044363087 scopus 로고    scopus 로고
    • Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens
    • Euer NI, Kaul S, Deissler H, Mobus VJ, Zeillinger R and Weidle UH: Identification of L1CAM, Jagged2 and Neuromedin U as ovarian cancer-associated antigens. Oncol Rep 13: 375-387, 2005.
    • (2005) Oncol Rep , vol.13 , pp. 375-387
    • Euer, N.I.1    Kaul, S.2    Deissler, H.3    Mobus, V.J.4    Zeillinger, R.5    Weidle, U.H.6
  • 51
    • 0034213658 scopus 로고    scopus 로고
    • Differential expression of alternatively spliced neural cell adhesion molecule L1 isoforms during oligodendrocyte maturation
    • Itoh K, Sakurai Y, Asou H and Umeda M: Differential expression of alternatively spliced neural cell adhesion molecule L1 isoforms during oligodendrocyte maturation. J Neurosci Res 60: 579-586, 2000.
    • (2000) J Neurosci Res , vol.60 , pp. 579-586
    • Itoh, K.1    Sakurai, Y.2    Asou, H.3    Umeda, M.4
  • 52
    • 0029066131 scopus 로고
    • Exon 2 of the gene for neural cell adhesion molecule L1 is alternatively spliced in B-cells
    • Jouet M, Rosenthal A and Kenwrick S: Exon 2 of the gene for neural cell adhesion molecule L1 is alternatively spliced in B-cells. Brain Res Mol Brain Res 30: 378-380, 1995.
    • (1995) Brain Res Mol Brain Res , vol.30 , pp. 378-380
    • Jouet, M.1    Rosenthal, A.2    Kenwrick, S.3
  • 53
    • 0026477126 scopus 로고
    • Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA
    • Reid RA and Hemperly JJ: Variants of human L1 cell adhesion molecule arise through alternate splicing of RNA: J Mol Neurosci 3: 127-135, 1992.
    • (1992) J Mol Neurosci , vol.3 , pp. 127-135
    • Reid, R.A.1    Hemperly, J.J.2
  • 54
    • 0029941632 scopus 로고    scopus 로고
    • A non-neuronal isoform of cell adhesion molecule L1: Tissue-specific expression and functional analysis
    • Takeda Y, Asou H, Murakami Y, Miura M, Kobayashi M and Uyemura K: A non-neuronal isoform of cell adhesion molecule L1: tissue-specific expression and functional analysis. J Neurochem 66: 2338-2349, 1996.
    • (1996) J Neurochem , vol.66 , pp. 2338-2349
    • Takeda, Y.1    Asou, H.2    Murakami, Y.3    Miura, M.4    Kobayashi, M.5    Uyemura, K.6
  • 55
    • 0035980022 scopus 로고    scopus 로고
    • Alternative use of a mini exon of the L1 gene affects L1 binding to neural ligands
    • De Angelis E, Brummendorf T, Cheng L, Lemmon V and Kenwrick S: Alternative use of a mini exon of the L1 gene affects L1 binding to neural ligands. J Biol Chem 276: 32738-32742, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 32738-32742
    • De Angelis, E.1    Brummendorf, T.2    Cheng, L.3    Lemmon, V.4    Kenwrick, S.5
  • 56
    • 0036254715 scopus 로고    scopus 로고
    • L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2
    • Jacob J, Haspel J, Kane-Goldsmith N and Grumet M: L1 mediated homophilic binding and neurite outgrowth are modulated by alternative splicing of exon 2. J Neurobiol 51: 177-189, 2002.
    • (2002) J Neurobiol , vol.51 , pp. 177-189
    • Jacob, J.1    Haspel, J.2    Kane-Goldsmith, N.3    Grumet, M.4
  • 57
    • 0035846950 scopus 로고    scopus 로고
    • The role of endocytosis in regulating L1-mediated adhesion
    • Long KE, Asou H, Snider MD and Lemmon V: The role of endocytosis in regulating L1-mediated adhesion. J Biol Chem 276: 1285-1290, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 1285-1290
    • Long, K.E.1    Asou, H.2    Snider, M.D.3    Lemmon, V.4
  • 58
    • 12144267589 scopus 로고    scopus 로고
    • L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region
    • Cheng L, Itoh K and Lemmon V: L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region. J Neurosci 25: 395-403, 2005.
    • (2005) J Neurosci , vol.25 , pp. 395-403
    • Cheng, L.1    Itoh, K.2    Lemmon, V.3
  • 59
    • 0032525174 scopus 로고    scopus 로고
    • A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone
    • Kamiguchi H and Lemmon V: A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J Neurosci 18: 3749-3756, 1998.
    • (1998) J Neurosci , vol.18 , pp. 3749-3756
    • Kamiguchi, H.1    Lemmon, V.2
  • 60
    • 0033621478 scopus 로고    scopus 로고
    • Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
    • Schaefer AW, Kamiguchi H, Wong EV, Beach CM, Landreth G and Lemmon V: Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization. J Biol Chem 274: 37965-37973, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 37965-37973
    • Schaefer, A.W.1    Kamiguchi, H.2    Wong, E.V.3    Beach, C.M.4    Landreth, G.5    Lemmon, V.6
  • 61
    • 29144457439 scopus 로고    scopus 로고
    • Endocytosis of betal integrins is an early event in migration promoted by the cell adhesion molecule L1
    • Panicker AK, Buhusi M, Erickson A and Maness PF: Endocytosis of betal integrins is an early event in migration promoted by the cell adhesion molecule L1. Exp Cell Res 31: 299-307, 2006.
    • (2006) Exp Cell Res , vol.31 , pp. 299-307
    • Panicker, A.K.1    Buhusi, M.2    Erickson, A.3    Maness, P.F.4
  • 65
    • 0028364617 scopus 로고
    • Internalization and degradation of monoclonal antibody chCE7 by human neuroblastoma cells
    • Novak-Hofer I, Amstutz HP, Morgenthaler JJ and Schubiger PA: Internalization and degradation of monoclonal antibody chCE7 by human neuroblastoma cells. Int J Cancer 57: 427-432. 1994.
    • (1994) Int J Cancer , vol.57 , pp. 427-432
    • Novak-Hofer, I.1    Amstutz, H.P.2    Morgenthaler, J.J.3    Schubiger, P.A.4
  • 67
    • 0038666527 scopus 로고    scopus 로고
    • High yield production of recombinant antibody fragments in HEK-293 cell using sodium butyrate
    • Grünberg J, Knogler K, Waibel R and Novak-Hofer I: High yield production of recombinant antibody fragments in HEK-293 cell using sodium butyrate. Biotechniques 34: 968-972, 2003.
    • (2003) Biotechniques , vol.34 , pp. 968-972
    • Grünberg, J.1    Knogler, K.2    Waibel, R.3    Novak-Hofer, I.4
  • 68
    • 31544439090 scopus 로고    scopus 로고
    • Efficient inhibition of intraperitoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment
    • Arlt MJE, Novak-Hofer I, Gast D, Gschwend V, Moldenhauer G, Grünberg J, Honer M, Schubiger PA, Altevogt P and Krüger A: Efficient inhibition of intraperitoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. Cancer Res 66: 936-943, 2006.
    • (2006) Cancer Res , vol.66 , pp. 936-943
    • Arlt, M.J.E.1    Novak-Hofer, I.2    Gast, D.3    Gschwend, V.4    Moldenhauer, G.5    Grünberg, J.6    Honer, M.7    Schubiger, P.A.8    Altevogt, P.9    Krüger, A.10
  • 69
    • 39149107444 scopus 로고    scopus 로고
    • Antibodies directed against L1-CAM synergize with genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells
    • Novak-Hofer I, Cohrs S, Grünberg J, Friedli A, Schlatter M, Pfeifer M, Altevogt P and Schubiger P: Antibodies directed against L1-CAM synergize with genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells. Cancer Letters 261: 193-204, 2003.
    • (2003) Cancer Letters , vol.261 , pp. 193-204
    • Novak-Hofer, I.1    Cohrs, S.2    Grünberg, J.3    Friedli, A.4    Schlatter, M.5    Pfeifer, M.6    Altevogt, P.7    Schubiger, P.8
  • 71
    • 34250885100 scopus 로고    scopus 로고
    • The L1 cell adhesion molecule as a target for radioimmunotherapy
    • Novak-Hofer I: The L1 cell adhesion molecule as a target for radioimmunotherapy. Cancer Biother Radiopharm 22: 175-184, 2007.
    • (2007) Cancer Biother Radiopharm , vol.22 , pp. 175-184
    • Novak-Hofer, I.1
  • 72
    • 75149140556 scopus 로고    scopus 로고
    • Evaluation of different single chain constructs based on antineuroblastoma mab chCE7
    • Novak-Hofer I, Carrel F, Armstutz H, Hasler P and Schubiger PA: Evaluation of different single chain constructs based on antineuroblastoma mab chCE7. Immunotechnology 2: 304-314, 1996.
    • (1996) Immunotechnology , vol.2 , pp. 304-314
    • Novak-Hofer, I.1    Carrel, F.2    Armstutz, H.3    Hasler, P.4    Schubiger, P.A.5
  • 73
    • 33749429154 scopus 로고    scopus 로고
    • 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: Influence of the number of chelators on the in vitro and in vivo properties
    • 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: influence of the number of chelators on the in vitro and in vivo properties. Nucl Med Biol 33: 883-889, 2006.
    • (2006) Nucl Med Biol , vol.33 , pp. 883-889
    • Knogler, K.1    Grünberg, J.2    Novak-Hofer, I.3    Zimmermann, K.4    Schubiger, P.A.5
  • 75
    • 0034745221 scopus 로고    scopus 로고
    • A comparison of targeting neuroblastoma with MLBG and anti-L1-CAM antibody mAbchCE7: Therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients
    • Hoefnagel CA, Rutgers M, Buitenhuis CA, Smets LA, de Kraker J, Meli M, Carrel F, Amstutz H and Novak-Hofer I: A comparison of targeting neuroblastoma with MLBG and anti-L1-CAM antibody mAbchCE7: therapeutic efficacy in a neuroblastoma xenograft model and imaging of neuroblastoma patients. Eur J Nucl Med 28: 359-368, 2001.
    • (2001) Eur J Nucl Med , vol.28 , pp. 359-368
    • Hoefnagel, C.A.1    Rutgers, M.2    Buitenhuis, C.A.3    Smets, L.A.4    de Kraker, J.5    Meli, M.6    Carrel, F.7    Amstutz, H.8    Novak-Hofer, I.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.