Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependent

Carcinogenesis

Volumn 33, Issue 1, 2012, Pages 84-93

  Schäfer, Heiner ^a   Geismann, Claudia ^a   Heneweer, Carola ^a   Egberts, Jan Hendrik ^a   Korniienko, Olena ^a   Kiefel, Helena ^b   Moldenhauer, Gerhard ^b   Bachem, Max G ^c   Kalthoff, Holger ^a   Altevogt, Peter ^b   Sebens, Susanne ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN; NERVE CELL ADHESION MOLECULE L1; PROTEIN ANTIBODY; UVOMORULIN; VIMENTIN;

ADULT; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MOUSE; MYOFIBROBLAST; NONHUMAN; PANCREAS CELL; PANCREATIC CARCINOGENESIS; PANCREATIC DUCTAL EPITHELIAL CELL; PANCREATIC MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

EID: 84855380754     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr262     Document Type: Article

References (50)

1. Siegel,R. et al. (2011) Cancer statistics, 2011. CA Cancer J. Clin., 61, 212-236.
2. Schneider,G. et al. (2005) Pancreatic cancer: basic and clinical aspects. Gastroenterology, 128, 1606-1625.
3. Farrow,B. et al. (2002) Inflammation and the development of pancreatic cancer. Surg. Oncol., 10, 153-169.
4. Luttges,J. et al. (2005) Pancreatic ductal adenocarcinoma and its precursors. Pathologe, 26, 12-17.
5. Yen,T.W. et al. (2002) Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas. Surgery, 131, 129-134.
6. Bhowmick,N.A. et al. (2004) Stromal fibroblasts in cancer initiation and progression. Nature, 432, 332-337.
7. Kleeff,J. et al. (2007) Pancreatic cancer microenvironment. Int. J. Cancer, 121, 699-705.
8. Muerkoster,S. et al. (2004) Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. Cancer Res., 64, 1331-1337.
9. Guerra,C. et al. (2007) Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by k-ras oncogenes in adult mice. Cancer Cell, 11, 291-302.
10. Moskovitz,A.H. et al. (2003) Chromosomal instability in pancreatic ductal cells from patients with chronic pancreatitis and pancreatic adenocarcinoma. Genes Chromosomes Cancer, 37, 201-206.
11. Baumgart,M. et al. (2010) Genomic instability at both the base pair level and the chromosomal level is detectable in earliest PanIN lesions in tissues of chronic pancreatitis. Pancreas, 39, 1093-1103.
12. Bhowmick,N.A. et al. (2001) Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell, 12, 27-36.
13. Guarino,M. (2007) Epithelial-mesenchymal transition and tumour invasion. Int. J. Biochem. Cell Biol., 39, 2153-2160.
14. Löhr,M. et al. (2001) Transforming growth factor-b1 induces desmoplasia in an experimental model of human pancreatic carcinoma. Cancer Res., 61, 550-555.
15. Bachem,M.G. et al. (2005) Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology, 128, 907-921.
16. Bachem,M.G. et al. (2008) Pancreatic stellate cells-role in pancreatic cancer. Langenbecks Arch. Surg., 393, 891-900.
17. Pilarsky,C. et al. (2008) Activation of Wnt signalling in stroma from pancreatic cancer identified by gene expression profiling. J. Cell. Mol. Med., 12, 2823-2835.
18. Geismann,C. et al. (2009) Up-regulation of L1CAM in pancreatic duct cells is transforming Growth Factor b1- and Slug-dependent: role in malignant transformation of pancreatic cancer. Cancer Res., 69, 4517-4526.
19. Gast,D. et al. (2005) L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas. Int. J. Cancer, 115, 658-665.
20. Gavert,N. et al. (2005) L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J. Cell Biol., 168, 633-642.
21. Kaifi,J.T. et al. (2007) L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Mod. Pathol., 20, 1183-1190.
22. Sebens Müerköster,S. et al. (2007) Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells. Oncogene, 26, 2759-2768.
23. Bergmann,F. et al. (2010) Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarinoma. Oncol. Rep., 24, 909-915.
24. Ben,Q.-W. et al. (2010) Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. Ann. Surg. Oncol., 17, 2213-2221.
25. Fogel,M. et al. (2003) L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet, 362, 869-875.
26. Arlt,M.J. et al. (2006) Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. Cancer Res., 66, 936-943.
27. Ouyang,H. et al. (2000) Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am. J. Pathol., 157, 1623-1631.
28. Furukawa,T. et al. (1996) Long-term culture and immortalization of epithelial cells from normal adult human pancreatic ducts transfected by the E6E7 gene of human papilloma virus 16. Am. J. Pathol., 148, 1763-1770.
29. Liu,N. et al. (1998) Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma. Am. J. Pathol., 153, 263-269.
30. Muerkoster,S.S. et al. (2008) Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma-epigenetic downregulation of caspases. Int. J. Cancer, 123, 1751-1760.
31. Riedle,S. et al. (2009) Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity. Biochem. J., 420, 391-402.
32. Stoeck,A. et al. (2006) L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells. Cancer Lett., 239, 212-226.
33. Wolterink,S. et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res., 70, 2504-2515.
34. Tiwari,S. et al. (2011) Assessment of anti-inflammatory tumor treatment efficacy by longitudinal monitoring employing sonographic micro morphology in a preclinical mouse model. BMC Med. Imaging, 11, 15.
35. Mechtersheimer,S. et al. (2001) Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J. Cell Biol., 155, 661-673.
36. Fujita,H. et al. (2010) Alpha-smooth muscle actin expressing stroma promotes an aggressive tumor biology in pancreatic ductal adenocarcinoma. Pancreas, 39, 1254-1262.
37. Qian,J. et al. (2005) In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by k-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res., 65, 5045-5052.
38. Löhr,M. et al. (2001) Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras. Virchows Arch., 438, 581-590.
39. Agbunag,C. et al. (2004) Oncogenic k-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells. Cancer Res., 64, 5659-5663.
40. Hingorani,S.R. et al. (2003) Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell, 4, 437-450.
41. Imai,T. et al. (2004) Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Hum. Pathol., 35, 1469-1476.
42. Kowalski,P.J. et al. (2003) E-cadherin expression in primary carcinoma of the breast and its distant metastases. Breast Cancer Res., 5, R217-R222.
43. Rubin,M.A. et al. (2001) E-cadherin expression in prostate cancer: a broad survey using high-density tissue microarray technology. Hum. Pathol., 32, 690-697.
44. Wells,A. et al. (2008) E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas. Clin. Exp. Metastasis, 25, 621-628.
45. Gavert,N. et al. (2007) Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res., 67, 7703-7712.
46. Gavert,N. et al. (2011) L1-mediated colon cancer cell metastasis does not require changes in EMTand cancer stem cell markers. Mol. Cancer Res., 9, 14-24.
47. Hwang,R.F. et al. (2008) Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res., 68, 918-926.
48. Bao,S. et al. (2008) Targeting cancer stem cells through L1CAM suppreses glioma growth. Cancer Res., 68, 6043-6048.
49. Cheng,L. et al. (2011) L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J., 30, 800-813.
50. Kastan,M.B. et al. (2004) Cell-cycle checkpoints and cancer. Nature, 432, 316-323.