Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment

Oncotarget

Volumn 5, Issue 17, 2014, Pages 7734-7747

  De, Gejing ^a   Ko, Jae Kyun ^b,c   Tan, Tao ^d   Zhu, Hua ^a   Li, Haichang ^a   Ma, Jianjie ^a,b,d  

^a OHIO STATE UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Mutagenex Inc   (United States)

^d TRIM edicine Inc   (United States)

Author keywords

Apoptosis; ATAP iRGD; Cancer therapy; Integrin; Mitochondria; Peptide

Indexed keywords

AMPHIPATHIC TAIL ANCHORING PEPTIDE; ANTINEOPLASTIC AGENT; CYTOCHROME C; DRUG ADDITIVE; INTERNALIZING ARGINYLGLYCYLASPARTYLSERINE PEPTIDE; M8 PEPTIDE; UNCLASSIFIED DRUG; BCL2-RELATED PROTEIN A1; N-END CYSTEINE PEPTIDE TUMOR-HOMING PEPTIDE; OLIGOPEPTIDE; PEPTIDE; PROTEIN BCL 2;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG TARGETING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PROSTATE CANCER; PROTEIN SECRETION; TOXICITY TESTING; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; CHEMISTRY; DRUG SCREENING; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; PATHOLOGY; PROCEDURES; PROSTATE TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; HUMANS; MALE; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MOLECULAR TARGETED THERAPY; OLIGOPEPTIDES; PEPTIDES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84907494465     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2301     Document Type: Article

References (44)

1. Lien S and Lowman HB. Therapeutic peptides. Trends in biotechnology. 2003; 21(12):556-562.
2. Vlieghe P, Lisowski V, Martinez J and Khrestchatisky M. Synthetic therapeutic peptides: science and market. Drug discovery today. 2010; 15(1-2):40-56.
3. Thundimadathil J. Cancer treatment using peptides: current therapies and future prospects. Journal of amino acids. 2012; 2012:967347.
4. Mulder KC, Lima LA, Miranda VJ, Dias SC and Franco OL. Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Frontiers in microbiology. 2013; 4:321.
5. Gurpinar E, Grizzle WE and Piazza GA. NSAIDs inhibit tumorigenesis, but how? Clinical cancer research: an official journal of the American Association for Cancer Research. 2014; 20(5):1104-1113.
6. Jacotot E, Deniaud A, Borgne-Sanchez A, Touat Z, Briand JP, Le Bras M and Brenner C. Therapeutic peptides: Targeting the mitochondrion to modulate apoptosis. Biochimica et biophysica acta. 2006; 1757(9-10):1312-1323.
7. Curnis F, Sacchi A, Borgna L, Magni F, Gasparri A and Corti A. Enhancement of tumor necrosis factor alpha antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nature biotechnology. 2000; 18(11):1185-1190.
8. Arap W, Pasqualini R and Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 1998; 279(5349):377-380.
9. Koivunen E, Arap W, Valtanen H, Rainisalo A, Medina OP, Heikkila P, Kantor C, Gahmberg CG, Salo T, Konttinen YT, Sorsa T, Ruoslahti E and Pasqualini R. Tumor targeting with a selective gelatinase inhibitor. Nature biotechnology. 1999; 17(8):768-774.
10. Pasqualini R and Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature. 1996; 380(6572):364-366.
11. Ruoslahti E. RGD and other recognition sequences for integrins. Annual review of cell and developmental biology. 1996; 12:697-715.
12. Pytela R, Pierschbacher MD and Ruoslahti E. Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell. 1985; 40(1):191-198.
13. Koivunen E, Gay DA and Ruoslahti E. Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library. The Journal of biological chemistry. 1993; 268(27):20205-20210.
14. Healy JM, Murayama O, Maeda T, Yoshino K, Sekiguchi K and Kikuchi M. Peptide ligands for integrin alpha v beta 3 selected from random phage display libraries. Biochemistry. 1995; 34(12):3948-3955.
15. Danhier F, Le Breton A and Preat V. RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. Molecular pharmaceutics. 2012; 9(11):2961-2973.
16. Enback J and Laakkonen P. Tumour-homing peptides: tools for targeting, imaging and destruction. Biochemical Society transactions. 2007; 35(Pt 4):780-783.
17. Ye Y, Zhu L, Ma Y, Niu G and Chen X. Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging. Bioorganic & medicinal chemistry letters. 2011; 21(4):1146-1150.
18. Sugahara KN, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Girard OM, Hanahan D, Mattrey RF and Ruoslahti E. Tissue-penetrating delivery of compounds and nanoparticles into tumors. Cancer Cell. 2009; 16(6):510-520.
19. Teesalu T, Sugahara KN, Kotamraju VR and Ruoslahti E. C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(38):16157-16162.
20. Sugahara KN, Teesalu T, Karmali PP, Kotamraju VR, Agemy L, Greenwald DR and Ruoslahti E. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science. 2010; 328(5981):1031-1035.
21. Constance JE and Lim CS. Targeting malignant mitochondria with therapeutic peptides. Therapeutic delivery. 2012; 3(8):961-979.
22. Fulda S, Galluzzi L and Kroemer G. Targeting mitochondria for cancer therapy. Nature reviews Drug discovery. 2010; 9(6):447-464.
23. Hockenbery DM. Targeting mitochondria for cancer therapy. Environmental and molecular mutagenesis. 2010; 51(5):476-489.
24. Javadpour MM, Juban MM, Lo WC, Bishop SM, Alberty JB, Cowell SM, Becker CL and McLaughlin ML. De novo antimicrobial peptides with low mammalian cell toxicity. Journal of medicinal chemistry. 1996; 39(16):3107-3113.
25. Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE and Pasqualini R. Anti-cancer activity of targeted pro-apoptotic peptides. Nature medicine. 1999; 5(9):1032-1038.
26. Smolarczyk R, Cichon T, Graja K, Hucz J, Sochanik A and Szala S. Antitumor effect of RGD-4C-GG-D(KLAKLAK)2 peptide in mouse B16(F10) melanoma model. Acta biochimica Polonica. 2006; 53(4):801-805.
27. Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL and Korsmeyer SJ. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science. 2004; 305(5689):1466-1470.
28. Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM and Huang DC. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 2007; 315(5813):856-859.
29. Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S and Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer cell. 2002; 2(3):183-192.
30. Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL and Korsmeyer SJ. A stapled BID BH3 helix directly binds and activates BAX. Molecular cell. 2006; 24(2):199-210.
31. Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 2005; 435(7042):677-681.
32. van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW and Huang DC. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer cell. 2006; 10(5):389-399.
33. Ko JK, Choi KH, Pan Z, Lin P, Weisleder N, Kim CW and Ma J. The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. Journal of cell science. 2007; 120(Pt 16):2912-2923.
34. Ko JK, Choi KH, Kim HJ, Choi HY, Yeo DJ, Park SO, Yang WS, Kim YN and Kim CW. Conversion of Bfl-1, an anti-apoptotic Bcl-2 family protein, to a potent pro-apoptotic protein by fusion with green fluorescent protein (GFP). FEBS letters. 2003; 551(1-3):29-36.
35. Ko JK, Choi KH, Peng J, He F, Zhang Z, Weisleder N, Lin J and Ma J. Amphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanisms. The Journal of biological chemistry. 2011; 286(11):9038-9048.
36. Song JH, Kandasamy K and Kraft AS. ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis. The Journal of biological chemistry. 2008; 283(36):25003-25013.
37. Guerrero CA, Mendez E, Zarate S, Isa P, Lopez S and Arias CF. Integrin alpha(v)beta(3) mediates rotavirus cell entry. Proceedings of the National Academy of Sciences of the United States of America. 2000; 97(26):14644-14649.
38. Yang JZ, Chen W and Borchardt RT. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs. The Journal of pharmacology and experimental therapeutics. 2002; 303(2):840-848.
39. Hershko A, Heller H, Eytan E, Kaklij G and Rose IA. Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. Proceedings of the National Academy of Sciences of the United States of America. 1984; 81(22):7021-7025.
40. Antosova Z, Mackova M, Kral V and Macek T. Therapeutic application of peptides and proteins: parenteral forever? Trends in biotechnology. 2009; 27(11):628-635.
41. Hou Z, Sang S, You H, Lee MJ, Hong J, Chin KV and Yang CS. Mechanism of action of (-)-epigallocatechin-3-gallate: auto-oxidation-dependent inactivation of epidermal growth factor receptor and direct effects on growth inhibition in human esophageal cancer KYSE 150 cells. Cancer research. 2005; 65(17):8049-8056.
42. 2+ oscillations in human esophageal squamous cell carcinoma. Oncotarget. 2014.
43. Unkila M, McColl KS, Thomenius MJ, Heiskanen K and Distelhorst CW. Unreliability of the cytochrome c-enhanced green fluorescent fusion protein as a marker of cytochrome c release in cells that overexpress Bcl-2. The Journal of biological chemistry. 2001; 276(42):39132-39137.
44. Feldman JP. A mathematical model for tumor volume evaluation using two-dimensions J Appl Quan Meth. 2009; 4 (4):455.