Overexpression of metallothionein I/II: A new feature of thyroid follicular cells in graves' disease

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 2, 2012, Pages 446-454

  Ruiz Riol, M ^a   Martinez Arconada M J ^a   Alonso, N ^b   Soldevila, B ^b   Marchena, D ^a   Armengol, M P ^a   Sanmarti A ^b   Pujol Borrell, Ricardo ^a   Martinez Caceres E M ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HLA ANTIGEN CLASS 2; METALLOTHIONEIN I; METALLOTHIONEIN II; ZINC;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; CELL STRESS; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; GRAVES DISEASE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LYMPHOCYTIC INFILTRATION; MALE; MORPHOMETRICS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID FOLLICLE CELL;

ADOLESCENT; ADULT; AGED; CELLS, CULTURED; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GRAVES DISEASE; HUMANS; MALE; METALLOTHIONEIN; MIDDLE AGED; STRESS, PHYSIOLOGICAL; THYROID GLAND; UP-REGULATION; YOUNG ADULT;

EID: 84856804442     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1429     Document Type: Article

References (36)

1. Weetmann AP 2007 The genetics of autoimmune thyroid diseases In: Wiersinga WM, Drexhage HA, Weetman AP, Butz S, eds. The thyroid and autoimmunity. Stuttgart, Germany: Georg Thieme Verlag KG; 54-59
2. Roitt IM, Doniach D 1960 Thyroid auto-immunity. Br Med Bull 16:152-158
3. Matzinger P 2002 The danger model: a renewed sense of self. Science 296:301-305 (Pubitemid 34303674)
4. Hanafusa T, Pujol-Borrell R, Chiovato L, Russell RC, Doniach D, Bottazzo GF 1983 Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 2:1111-1115 (Pubitemid 14242393)
5. Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M 1983 Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2:1115-1119
6. Tolosa E, Roura C, Catálfamo M, Martí M, Lucas-Martín A, Sanmartí A, Salinas I, Obiols G, Foz-Sala M, Pujol-Borrell R 1992 Expression of intercellular adhesion molecule-1 in thyroid follicular cells in autoimmune, non-autoimmune and neoplastic diseases of the thyroid gland: discordance with HLA. J Autoimmun 5:107-118
7. Bagnasco M, Pesce GP, Caretto A, Paolieri F, Pronzato C, Villaggio B, Giordano C, Betterle C, Canonica GW 1995 Follicular thyroid cells of autoimmune thyroiditis may coexpress ICAM-1 (CD54) and its natural ligand LFA-1 (CD11a/CD18). J Allergy Clin Immunol 95:1036-1043
8. Watson PF, Pickerill AP, Davies R, Weetman AP 1995 Semi-quantitative analysis of interleukin-1α, interleukin-6 and interleukin-8 mRNA expression by human thyrocytes. J Mol Endocrinol 15: 11-21
9. Sospedra M, Obiols G, Babi LF, Tolosa E, Vargas F, Roura-Mir C, Lucas-Martin A, Ercilla G, Pujol-Borrell R 1995 Hyperinducibility of HLA class-II expression of thyroid follicular cells from Graves'disease. A primary defect? J Immunol 154:4213-4222
10. Catálfamo M, Serradell L, Roura-Mir C, Kolkowski E, Sospedra M, Vives-Pi M, Vargas-Nieto F, Pujol-Borrell R, Jaraquemada D 1999 HLA DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules. Int Immunol 11:269-277 (Pubitemid 29074101)
11. Sospedra M, Tolosa E, Armengol P, Ashhab Y, Urlinger S, Lucas- Martin A, Foz-Sala M, Jaraquemada D, Pujol-Borrell R 1997 Hyperexpression of transporter in antigen processing-1 (TAP-1) in thyroid glands affected by autoimmunity: a contributing factor to the breach of tolerance to thyroid antigens? Clin Exp Immunol 109: 98-106
12. Pujo-Borrell R, Hanafusa T, Chiovato L, Bottazzo GF 1983 Lectin-induced expression of DR antigen on human cultured follicular thyroid cells. Nature 304:71-73 (Pubitemid 13063109)
13. Bianchi ME 2007 DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 81:1-5 (Pubitemid 46028489)
14. Ruiz-Riol M, Barnils Mdel P, Colobran Oriol R, Pla AS, Borràs Serres FE, Lucas-Martin A, Martínez Cáceres EM, Pujol-Borrell R 2011 Analysis of the cumulative changes in Graves' disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors. J Autoimmun 36:189-200
15. Vasák M 2005 Advances in metallothionein structure and functions. J Trace Elem Med Biol 19:13-17 (Pubitemid 41253912)
16. Coyle P, Philcox JC, Carey LC, Rofe AM 2002 Metallothionein: the multipurpose protein. Cell Mol Life Sci 59:627-647 (Pubitemid 34460681)
17. Theocharis SE, Margeli AP, Klijanienko JT, Kouraklis GP 2004 Metallothionein expression in human neoplasia. Histopathology 45:103-118 (Pubitemid 39120406)
18. Dziegiel P 2004 Expression of metallothioneins in tumor cells. Pol J Pathol 55:3-12 (Pubitemid 38596165)
19. Espejo C, Carrasco J, Hidalgo J, Penkowa M, Garcia A, Sáez-Torres I, Martínez-Cáceres EM 2001 Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis. Neuroscience 105:1055-1065 (Pubitemid 32786817)
20. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg JR, Raine CS, Heller R, Steinman L 2002 Gene microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8:500-508 (Pubitemid 34546753)
21. Penkowa M, Espejo C, Ortega-Aznar A, Hidalgo J, Montalban X, Martínez Cáceres EM 2003 Metallothionein expression in the central nervous system of multiple sclerosis patients. Cell Mol Life Sci 60:1258-1266 (Pubitemid 36791927)
22. Chung RS, Hidalgo J, West AK 2008 New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration. J Neurochem 104:14-20 (Pubitemid 350265070)
23. Bartalena L Tanda ML, Piantanida E, Lai A, Compri E, Lombardi V2007 Environment and thyroid autoimmunity In: Wiersing a WM, Drexhage HA, Weetman AP, Butz S, eds. The thyroid and autoimmunity. Stuttgart, Germany: Georg Thieme Verlag KG; 60-73
24. Lucas-Martin A, Foz-Sala M, Todd I, Bottazzo GF, Pujol-Borrell R 1988 Occurrence of thyrocyte HLA class-II expression in a wide variety of thyroid diseases: Relationship with lymphocytic infiltration and thyroid autoantibodies. J Clin Endocrinol Metab 66:367-375 (Pubitemid 18065183)
25. Belfiore A, Mauerhoff T, Pujol-Borrell R, Badenhoop K, Buscema M, Mirakian R, Bottazzo GF 1991 De novo HLA class II and enhanced HLA class I molecule expression in SV40 transfected human thyroid epithelial cells. J Autoimmun 4:397-414
26. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159 (Pubitemid 17064313)
27. Espejo C, Martínez-Cáceres EM 2005 The role of methallothioneins in experimental autoimmune encephalomyelitis and multiple sclerosis. Ann NY Acad Sci 1051:88-96 (Pubitemid 41362735)
28. Zheng RQ, Abney E, Chu CQ, Field M, Grubeck-Loebenstein B, Maini RN, Feldmann M 1991 Detection of interleukin-6 and interleukin- 1 production in human thyroid epithelial cells by non-radio-active in situ hybridization and immunohistochemical methods. Clin Exp Immunol 83:314-319
29. Todd I, Pujol-Borrell R, Hammond LJ, Bottazzo GF, Feldmann M 1985 Interferon-γ induces HLA-DR expression by thyroid epithelium. Clin Exp Immunol 61:265-273 (Pubitemid 15247751)
30. + T and CCR7 B and T lymphocytes in thyroid autoimmune diseases. J Immunol 170: 6320-6328
31. Rasooly L, Burek CL, Rose NR 1996 Iodine-induced autoimmune thyroiditis in NOD.H-2h4 mice. Clin Immunol Immunopathol 81: 287-292 (Pubitemid 26414558)
32. Nartey N, Cherian MG, Banerjee D 1987 Immunohistochemical localization of metallothionein in human thyroid tumors. Am J Pathol 129:177-182 (Pubitemid 17157782)
33. Liu ZM, Chen GG, Shum CK, Vlantis AC, Cherian MG, Koropatnick J, van Hasselt CA 2007 Induction of functional MT1 and MT2 isoforms by calcium in anaplastic thyroid carcinoma cells. FEBS Lett 581:2465-2472
34. Ostrakhovitch EA, Olsson PE, Jiang S, Cherian MG 2006 Interaction of metallothionein with tumor suppressor p53 protein. FEBS Lett 580:1235-1238 (Pubitemid 43221983)
35. Pastuszewski W, Dziegiel P, Krecicki T, Podhorska-Okolow M, Ciesielska U, Gorzynska E, Zabel M 2007 Prognostic significance of metallothionein, p53 protein and ki-67 antigen expression in laryngeal cancer. Anticancer Res 27:335-342 (Pubitemid 46363351)
36. McLachlan SM, Rapoport B 2007 Thyroid peroxidase as an autoantigen. Thyroid 17:939-948 (Pubitemid 350071595)