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Volumn 4, Issue JUL, 2013, Pages

Which model better fits the role of Aire in the establishment of self-tolerance: The transcription model or the maturation model?

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; B7 ANTIGEN; C REACTIVE PROTEIN; CYTOKERATIN; CYTOKERATIN 5; GLUTAMATE DECARBOXYLASE 67; INVOLUCRIN; PEPTIDES AND PROTEINS; TISSUE RESTRICTED SELF ANTIGEN; UNCLASSIFIED DRUG;

EID: 84883679216     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00210     Document Type: Article
Times cited : (23)

References (32)
  • 1
    • 67549118180 scopus 로고    scopus 로고
    • Aire
    • doi:10.1146/annurev.immunol.25.022106.141532
    • Mathis D, Benoist C. Aire. Annu Rev Immunol (2009) 27:287-312. doi:10.1146/annurev.immunol.25.022106.141532
    • (2009) Annu Rev Immunol , vol.27 , pp. 287-312
    • Mathis, D.1    Benoist, C.2
  • 2
    • 78650376503 scopus 로고    scopus 로고
    • Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla
    • doi:10.1002/eji.201041024
    • Matsumoto M. Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla. Eur J Immunol (2011) 41:12-7. doi:10.1002/eji.201041024
    • (2011) Eur J Immunol , vol.41 , pp. 12-17
    • Matsumoto, M.1
  • 3
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the Aire protein
    • doi:10.1126/science.1075958
    • Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, et al. Projection of an immunological self shadow within the thymus by the Aire protein. Science (2002) 298:1395-401. doi:10.1126/science.1075958
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5    Turley, S.J.6
  • 4
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • doi:10.1016/j.cell.2009.12.030
    • Abramson J, Giraud M, Benoist C, Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell (2010) 140:123-35. doi:10.1016/j.cell.2009.12.030
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 5
    • 70450192681 scopus 로고    scopus 로고
    • AIRE activated tissue specific genes have histone modifications associated with inactive chromatin
    • doi:10.1093/hmg/ddp433
    • Org T, Rebane A, Kisand K, Laan M, Haljasorg U, Andreson R, et al. AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet (2009) 18:4699-710. doi:10.1093/hmg/ddp433
    • (2009) Hum Mol Genet , vol.18 , pp. 4699-4710
    • Org, T.1    Rebane, A.2    Kisand, K.3    Laan, M.4    Haljasorg, U.5    Andreson, R.6
  • 6
    • 80054065566 scopus 로고    scopus 로고
    • Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription
    • doi:10.1093/nar/gkr527
    • Zumer K, Plemenitas A, Saksela K, Peterlin BM. Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription. Nucleic Acids Res (2011) 39:7908-19. doi:10.1093/nar/gkr527
    • (2011) Nucleic Acids Res , vol.39 , pp. 7908-7919
    • Zumer, K.1    Plemenitas, A.2    Saksela, K.3    Peterlin, B.M.4
  • 7
    • 84874848684 scopus 로고    scopus 로고
    • The mechanism of tissue-restricted antigen gene expression by AIRE
    • doi:10.4049/jimmunol.1203210
    • Zumer K, Saksela K, Peterlin BM. The mechanism of tissue-restricted antigen gene expression by AIRE. J Immunol (2013) 190:2479-82. doi:10.4049/jimmunol.1203210
    • (2013) J Immunol , vol.190 , pp. 2479-2482
    • Zumer, K.1    Saksela, K.2    Peterlin, B.M.3
  • 8
    • 33847350111 scopus 로고    scopus 로고
    • Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation
    • Gillard GO, Dooley J, Erickson M, Peltonen L, Farr AG. Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol (2007) 178:3007-15.
    • (2007) J Immunol , vol.178 , pp. 3007-3015
    • Gillard, G.O.1    Dooley, J.2    Erickson, M.3    Peltonen, L.4    Farr, A.G.5
  • 9
    • 58149316251 scopus 로고    scopus 로고
    • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
    • doi:10.1084/jem.20080046
    • Yano M, Kuroda N, Han H, Meguro-Horike M, Nishikawa Y, Kiyonari H, et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med (2008) 205:2827-38. doi:10.1084/jem.20080046
    • (2008) J Exp Med , vol.205 , pp. 2827-2838
    • Yano, M.1    Kuroda, N.2    Han, H.3    Meguro-Horike, M.4    Nishikawa, Y.5    Kiyonari, H.6
  • 10
    • 84872711825 scopus 로고    scopus 로고
    • Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte -specific autoantigens
    • doi:10.3389/fimmu.2012.00019
    • Wang X, Laan M, Bichele R, Kisand K, Scott HS, Peterson P. Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte -specific autoantigens. Front Immunol (2012) 3:19. doi:10.3389/fimmu.2012.00019
    • (2012) Front Immunol , vol.3 , pp. 19
    • Wang, X.1    Laan, M.2    Bichele, R.3    Kisand, K.4    Scott, H.S.5    Peterson, P.6
  • 11
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • doi:10.1084/jem.20070795
    • Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 204:2521-8. doi:10.1084/jem.20070795
    • (2007) J Exp Med , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 12
    • 65449133931 scopus 로고    scopus 로고
    • Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype
    • doi:10.4049/jimmunol.0802124
    • Hubert FX, Kinkel SA, Crewther PE, Cannon PZ, Webster KE, Link M, et al. Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. J Immunol (2009) 182:3902-18. doi:10.4049/jimmunol.0802124
    • (2009) J Immunol , vol.182 , pp. 3902-3918
    • Hubert, F.X.1    Kinkel, S.A.2    Crewther, P.E.3    Cannon, P.Z.4    Webster, K.E.5    Link, M.6
  • 13
    • 13544262691 scopus 로고    scopus 로고
    • Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice
    • Kuroda N, Mitani T, Takeda N, Ishimaru N, Arakaki R, Hayashi Y, et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol (2005) 174:1862-70.
    • (2005) J Immunol , vol.174 , pp. 1862-1870
    • Kuroda, N.1    Mitani, T.2    Takeda, N.3    Ishimaru, N.4    Arakaki, R.5    Hayashi, Y.6
  • 14
    • 36448949476 scopus 로고    scopus 로고
    • Generating intrathymic microenvironments to establish T-cell tolerance
    • doi:10.1038/nri2187
    • Anderson G, Lane PJ, Jenkinson EJ. Generating intrathymic microenvironments to establish T-cell tolerance. Nat Rev Immunol (2007) 7:954-63. doi:10.1038/nri2187
    • (2007) Nat Rev Immunol , vol.7 , pp. 954-963
    • Anderson, G.1    Lane, P.J.2    Jenkinson, E.J.3
  • 15
    • 4544258485 scopus 로고    scopus 로고
    • Self-representation in the thymus: an extended view
    • doi:10.1038/nri1436
    • Kyewski B, Derbinski J. Self-representation in the thymus: an extended view. Nat Rev Immunol (2004) 4:688-98. doi:10.1038/nri1436
    • (2004) Nat Rev Immunol , vol.4 , pp. 688-698
    • Kyewski, B.1    Derbinski, J.2
  • 16
    • 52949125608 scopus 로고    scopus 로고
    • Transcriptional impact of Aire varies with cell type
    • doi:10.1073/pnas.0806616105
    • Guerau-de-Arellano M, Mathis D, Benoist C. Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A (2008) 105:14011-6. doi:10.1073/pnas.0806616105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14011-6
    • Guerau-de-Arellano, M.1    Mathis, D.2    Benoist, C.3
  • 17
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • doi:10.1146/annurev.immunol.23.021704.115601
    • Kyewski B, Klein L. A central role for central tolerance. Annu Rev Immunol (2006) 24:571-606. doi:10.1146/annurev.immunol.23.021704.115601
    • (2006) Annu Rev Immunol , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 18
    • 22344434168 scopus 로고    scopus 로고
    • Contrasting models of promiscuous gene expression by thymic epithelium
    • doi:10.1084/jem.20050976
    • Gillard GO, Farr AG. Contrasting models of promiscuous gene expression by thymic epithelium. J Exp Med (2005) 202:15-9. doi:10.1084/jem.20050976
    • (2005) J Exp Med , vol.202 , pp. 15-19
    • Gillard, G.O.1    Farr, A.G.2
  • 19
    • 56749184864 scopus 로고    scopus 로고
    • Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
    • doi:10.1073/pnas.0808069105
    • Villasenor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A (2008) 105:15854-9. doi:10.1073/pnas.0808069105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15854-9
    • Villasenor, J.1    Besse, W.2    Benoist, C.3    Mathis, D.4
  • 20
    • 84872494068 scopus 로고    scopus 로고
    • Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    • doi:10.1002/eji.201242761
    • Danso-Abeam D, Staats KA, Franckaert D, Van Den Bosch L, Liston A, Gray DH, et al. Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism. Eur J Immunol (2013) 43:75-84. doi:10.1002/eji.201242761
    • (2013) Eur J Immunol , vol.43 , pp. 75-84
    • Danso-Abeam, D.1    Staats, K.A.2    Franckaert, D.3    Van Den Bosch, L.4    Liston, A.5    Gray, D.H.6
  • 21
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • doi:10.1084/jem.20092144
    • Nishikawa Y, Hirota F, Yano M, Kitajima H, Miyazaki J, Kawamoto H, et al. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med (2010) 207:963-71. doi:10.1084/jem.20092144
    • (2010) J Exp Med , vol.207 , pp. 963-971
    • Nishikawa, Y.1    Hirota, F.2    Yano, M.3    Kitajima, H.4    Miyazaki, J.5    Kawamoto, H.6
  • 22
    • 77955602966 scopus 로고    scopus 로고
    • Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
    • doi:10.1073/pnas.1004436107
    • Koh AS, Kingston RE, Benoist C, Mathis D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A (2010) 107:13016-21. doi:10.1073/pnas.1004436107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13016-21
    • Koh, A.S.1    Kingston, R.E.2    Benoist, C.3    Mathis, D.4
  • 23
    • 63849337252 scopus 로고    scopus 로고
    • PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus
    • doi:10.4161/epi.3.6.7182
    • Musco G, Peterson P. PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics (2008) 3:310-4. doi:10.4161/epi.3.6.7182
    • (2008) Epigenetics , vol.3 , pp. 310-314
    • Musco, G.1    Peterson, P.2
  • 24
    • 33646477813 scopus 로고    scopus 로고
    • Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression
    • Gillard GO, Farr AG. Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J Immunol (2006) 176:5815-24.
    • (2006) J Immunol , vol.176 , pp. 5815-5824
    • Gillard, G.O.1    Farr, A.G.2
  • 25
    • 38649131259 scopus 로고    scopus 로고
    • Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
    • doi:10.1073/pnas.0707486105
    • Derbinski J, Pinto S, Rosch S, Hexel K, Kyewski B. Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci U S A (2008) 105:657-62. doi:10.1073/pnas.0707486105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 657-662
    • Derbinski, J.1    Pinto, S.2    Rosch, S.3    Hexel, K.4    Kyewski, B.5
  • 26
    • 38049026826 scopus 로고    scopus 로고
    • DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity
    • doi:10.1016/j.bbamcr.2007.09.003
    • Liiv I, Rebane A, Org T, Saare M, Maslovskaja J, Kisand K, et al. DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim Biophys Acta (2008) 1783:74-83. doi:10.1016/j.bbamcr.2007.09.003
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 74-83
    • Liiv, I.1    Rebane, A.2    Org, T.3    Saare, M.4    Maslovskaja, J.5    Kisand, K.6
  • 27
    • 23844558032 scopus 로고    scopus 로고
    • The cellular mechanism of Aire control of T cell tolerance
    • doi:10.1016/j.immuni.2005.07.005
    • Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 23:227-39. doi:10.1016/j.immuni.2005.07.005
    • (2005) Immunity , vol.23 , pp. 227-239
    • Anderson, M.S.1    Venanzi, E.S.2    Chen, Z.3    Berzins, S.P.4    Benoist, C.5    Mathis, D.6
  • 28
    • 36749066715 scopus 로고    scopus 로고
    • Developmental pathway of CD4+CD8-medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice
    • doi:10.1073/pnas.0708884104
    • Li J, Li Y, Yao JY, Jin R, Zhu MZ, Qian XP, et al. Developmental pathway of CD4+CD8-medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice. Proc Natl Acad Sci U S A (2007) 104:18175-80. doi:10.1073/pnas.0708884104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18175-80
    • Li, J.1    Li, Y.2    Yao, J.Y.3    Jin, R.4    Zhu, M.Z.5    Qian, X.P.6
  • 29
    • 76249101988 scopus 로고    scopus 로고
    • Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes
    • doi:10.4049/jimmunol.0804133
    • Laan M, Kisand K, Kont V, Moll K, Tserel L, Scott HS, et al. Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol (2009) 183:7682-91. doi:10.4049/jimmunol.0804133
    • (2009) J Immunol , vol.183 , pp. 7682-7691
    • Laan, M.1    Kisand, K.2    Kont, V.3    Moll, K.4    Tserel, L.5    Scott, H.S.6
  • 30
    • 79951715831 scopus 로고    scopus 로고
    • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
    • doi:10.1084/jem.20102327
    • Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, Jeker LT, et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 208:383-94. doi:10.1084/jem.20102327
    • (2011) J Exp Med , vol.208 , pp. 383-394
    • Lei, Y.1    Ripen, A.M.2    Ishimaru, N.3    Ohigashi, I.4    Nagasawa, T.5    Jeker, L.T.6
  • 31
    • 77952568022 scopus 로고    scopus 로고
    • Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance
    • doi:10.1038/ni.1874
    • Hinterberger M, Aichinger M, Da Costa O, Voehringer D, Hoffmann R, Klein L. Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance. Nat Immunol (2010) 11:512-9. doi:10.1038/ni.1874
    • (2010) Nat Immunol , vol.11 , pp. 512-519
    • Hinterberger, M.1    Aichinger, M.2    Da Costa, O.3    Voehringer, D.4    Hoffmann, R.5    Klein, L.6
  • 32
    • 84880009815 scopus 로고    scopus 로고
    • An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression
    • doi:10.1002/eji.201343343
    • Ucar O, Tykocinski LO, Dooley J, Liston A, Kyewski B. An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. Eur J Immunol (2013) 43:1769-78. doi:10.1002/eji.20134334
    • (2013) Eur J Immunol , vol.43 , pp. 1769-1778
    • Ucar, O.1    Tykocinski, L.O.2    Dooley, J.3    Liston, A.4    Kyewski, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.