Analysis of synthetic cathinones and associated psychoactive substances by ion mobility spectrometry

Forensic Science International

Volumn 244, Issue , 2014, Pages 196-206

  Joshi, Monica ^a   Cetroni, Bryan ^a   Camacho, Amanda ^b   Krueger, Clinton ^b   Midey, Anthony J ^b  

^a WEST CHESTER UNIVERSITY   (United States)

^b Excellims Corporation   (United States)

Author keywords

Bath salts; Cathinones; Dimethylamylamine; Electrospray ionization ion mobility spectrometry mass spectrometry; Ion mobility spectrometry (IMS); Mephedrone

Indexed keywords

3,4 METHYLENEDIOXY PYROVALERONE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 FLUOROMETHCATHINONE; 4 METHYL 2 HEXYLAMINE; 4' METHYL ALPHA PYRROLIDINOPROPIOPHENONE; 4' METHYLMETHCATHINONE; 5 IODO 2 AMINOINDANE; BUPHEDRONE; BUTYLONE; CATHINONE; ETHCATHINONE; METHAMPHETAMINE; METHCATHINONE; METHIOPROPAMINE; METHYLONE; NAPHYRONE; PSYCHOTROPIC AGENT; UNCLASSIFIED DRUG; ALKALOID; DESIGNER DRUG; NICKEL; RADIOISOTOPE;

ARTICLE; CHROMATOGRAPHY; DRUG DETERMINATION; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; INTERMETHOD COMPARISON; ION MOBILITY SPECTROMETRY; IONIZATION; LIMIT OF DETECTION; PROCESS DEVELOPMENT; QUALITATIVE ANALYSIS; REPRODUCIBILITY; SCREENING TEST; CHEMISTRY; PROCEDURES;

ALKALOIDS; DESIGNER DRUGS; NICKEL; PSYCHOTROPIC DRUGS; RADIOISOTOPES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84907484163     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.08.033     Document Type: Article

References (42)

1. Johnson L.A., Johnson R.L., Portier R.B. Current legal highs. J. Emerg. Med. 2013, 44(6):1108-1115. 10.1016/j.jemermed.2012.09.147.
2. Cottencin O., Rolland B., Karila L. New designer drugs (synthetic cannabinoids and synthetic cathinones): review of literature. Curr. Pharm. Des. 2014, 20(25):4106. 10.2174/13816128113199990622.
3. Rosenbaum C.D., Carreiro S.P., Babu K.M. Here today, gone tomorrow. . .and back again?. A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines. J. Med. Toxicol. 2012, 8(1):15-32. 10.1007/s13181-011-0202-2.
4. Kelly J.P. Cathinone derivatives: a review of their chemistry, pharmacology and toxicology. Drug Test Anal. 2011, 3(7-8):439-453. 10.1002/dta.313.
5. Prosser J.M., Nelson L.S. The toxicology of bath salts: a review of synthetic cathinones. J. Med. Toxicol. 2012, 8(1):33-42. 10.1007/s13181-011-0193-z.
6. Archer J.R., Dargan P.I., Lee H.M., Hudson S., Wood D.M. Trend analysis of anonymised pooled urine from portable street urinals in central London identifies variation in the use of novel psychoactive substances. Clin. Toxicol. (Phila). 2014, 52(3):160-165. 10.3109/15563650.2014.885982.
7. Kikura-Hanajiri R., Uchiyama N., Kawamura M., Ogata J., Goda Y. Prevalence of new designer drugs and their legal status in Japan. Yakugaku Zasshi. 2013, 133(1):31-40.
8. Péterfi A., Tarján A., Horváth G.C., Csesztregi T., Nyírády A. Changes in patterns of injecting drug use in Hungary: a shift to synthetic cathinones. Drug Test Anal. 2014, 10.1002/dta.1625.
9. Loeffler G., Hurst D., Penn A., Yung K. Spice, bath salts, and the U.S. military: the emergence of synthetic cannabinoid receptor agonists and cathinones in the U.S. Armed Forces. Mil. Med. 2012, 177(9):1041-1048.
10. DEA Schedules of controlled substances:Temporary placement of 10 synthetic cathinones into schedule I. Fed. Regist. 2014, 79(45):21. CFR Part 1308.
11. Fass J.A., Fass A.D., Garcia A.S. Synthetic cathinones (bath salts): legal status and patterns of abuse. Ann. Pharmacother. 2012, 46(3):436-441. 10.1345/aph.1Q628.
12. Favretto D., Pascali J.P., Tagliaro F. New challenges and innovation in forensic toxicology: focus on the New Psychoactive Substances. J. Chromatogr. A 2013, 1287:84-95. 10.1016/j.chroma.2012.12.049.
13. German C.L., Fleckenstein A.E., Hanson G.R. Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci. 2014, 97(1):2-8. 10.1016/j.lfs.2013.07.023.
14. Gershman J.A., Fass A.D. Synthetic cathinones ('bath salts'): legal and health care challenges. P&T 2012, 37(10):571-572. 595.
15. Mas-Morey P., Visser M.H., Winkelmolen L., Touw D.J. Clinical toxicology and management of intoxications with synthetic cathinones (bath salts). J. Pharm. Pract. 2013, 26(Aug (4)):353-357. 10.1177/0897190012465949.
16. Elliott S., Evans J. A 3-year review of new psychoactive substances in casework. Forensic Sci. Int. 2014, 243:55-60. 10.1016/j.forsciint.2014.04.017.
17. EMCDDA Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances 2011, European Monitoring Centre for Drugs and Drug Addiction, Luxembourg. 10.2810/40800.
18. DEA National Forensic Laboratory Information System: Year 2010 Annual Report 2011, U.S. Drug Enforcement Administration, Office of Diversion Control, Springfield, VA.
19. Archer R.P., Treble R., Williams K. Reference materials for new psychoactive substances. Drug Test Anal. 2011, 3(7-8):505-514. 10.1002/dta.317.
20. Hasegawa T., Takahashi K., Saijo M., Fukiwake T., Motoki Y. Current situation and issues for analyzing illegal drug products. Yakugaku Zasshi. 2013, 133(1):7-11. 10.1248/yakushi.12-00247-2.
21. Oulton S.R. SWGDRUG Criteria for Identification of Synthetic Drugs. Emerging Trends in Synthetic Drugs Workshop 2013, National Institute of Standards and Technology & Drug Enforcement Administration, Gaithersburg, MD, Personal communication.
22. Concheiro M., Anizan S., Ellefsen K., Huestis M.A. Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometry. Anal. Bioanal. Chem. 2013, 405(Nov(29)):9437-9448. 10.1007/s00216-013-7386-z.
23. Marinetti L.J., Antonides H.M. Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results. J. Anal. Toxicol. 2013, 37(3):135-146. 10.1093/jat/bks136.
24. Li L., Lurie I.S. Screening of seized emerging drugs by ultra-high performance liquid chromatography with photodiode array ultraviolet and mass spectrometric detection. Forensic Sci. Int. 2014, 237:100-111. 10.1016/j.forsciint.2014.01.018.
25. Nic Daeid N., Savage K.A., Ramsay D., Holland C., Sutcliffe O.B. Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 16 'legal high' cathinone derivatives. Sci. Justice 2014, 54(1):22-31. 10.1016/j.scijus.2013.08.004.
26. Uchiyama N., Matsuda S., Kawamura M., Shimokawa Y., Kikura-Hanajiri R., Aritake K., et al. Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products. Forensic Sci. Int. 2014, 243:1-13. 10.1016/j.forsciint.2014.03.013.
27. Zuba D. Identification of cathinones and other active components of 'legal highs' by mass spectrometric methods. TrAC Trends Anal. Chem. 2012, 32:15-30. 10.1016/j.trac.2011.09.009.
28. Jackson L.C. SWGDRUG Draft Recommendations on Analogues and Structural Class Determinations. Emerging Trends in Synthetic Drugs Workshop 2013, National Institute of Standards and Technology & Drug Enforcement Administration, Gaithersburg, MD, Personal communication.
29. Lesiak A.D., Musah R.A., Cody R.B., Domin M.A., Dane A.J., Shepard J.R. Direct analysis in real time mass spectrometry (DART-MS) of bath salt cathinone drug mixtures. Analyst 2013, 138(12):3424-3432. 10.1039/c3an00360d.
30. Swortwood M.J., Boland D.M., DeCaprio A.P. Determination of 32 cathinone derivatives and other designer drugs in serum by comprehensive LC-QQQ-MS/MS analysis. Anal. Bioanal. Chem. 2013, 405(4):1383-1397. 10.1007/s00216-012-6548-8.
31. Vircks K.E., Mulligan C.C. Rapid screening of synthetic cathinones as trace residues and in authentic seizures using a portable mass spectrometer equipped with desorption electrospray ionization. Rapid Commun. Mass Spectrom. 2012, 26(Dec (23)):2665-2672. 10.1002/rcm.6390.
32. Swortwood M.J., Hearn W.L., Decaprio A.P. Cross-reactivity of designer drugs, including cathinone derivatives, in commercial enzyme-linked immunosorbent assays. Drug Test Anal. 2013, 10.1002/dta.1489.
33. Ellefsen K.N., Anizan S., Castaneto M.S., Desrosiers N.A., Martin T.M., Klette K.L., et al. Validation of the only commercially available immunoassay for synthetic cathinones in urine: Randox Drugs of Abuse V Biochip Array Technology. Drug Test Anal. 2014, 10.1002/dta.1633.
34. Borsdorf H., Eiceman G. Ion mobility spectrometry: principles and applications. Appl. Spectrosc. Rev. 2006, 41(4):323-375. 10.1080/05704920600663469.
35. Borsdorf H., Mayer T., Zarejousheghani M., Eiceman G. Recent developments in ion mobility spectrometry. Appl. Spectrosc. Rev. 2011, 46(6):472-521. 10.1080/05704928.2011.582658.
36. Eiceman G.A., Karpas Z. Ion Mobility Spectrometry 2005, Taylor & Francis, Boca Raton, FL. second ed.
37. Midey A.J., Camacho A., Sampathkumaran J., Krueger C.A., Osgood M.A., Wu C. High-performance ion mobility spectrometry with direct electrospray ionization (ESI-HPIMS) for the detection of additives and contaminants in food. Anal. Chim. Acta 2013, 804:197-206. 10.1016/j.aca.2013.10.010.
38. Hilton C.K., Krueger C.A., Midey A.J., Osgood M., Wu J., Wu C. Improved analysis of explosives samples with electrospray ionization-high resolution ion mobility spectrometry (ESI-HRIMS). Int. J. Mass Spectrom. 2010, 298(1-3):64-71. 10.1016/j.ijms.2010.08.011.
39. Krueger C., Midey A., Kim T., Osgood M., Wu J., Wu C. High performance ion mobility spectrometry as a fast and low cost green analytical technology part I: Analysis of nutritional supplements. Int. J. Ion Mobility Spectrom. 2011, 14(2-3):71-79. 10.1007/s12127-011-0072-y.
40. Midey A.J., Patel A., Moraff C., Krueger C.A., Wu C. Improved detection of drugs of abuse using high-performance ion mobility spectrometry with electrospray ionization (ESI-HPIMS) for urine matrices. Talanta 2013, 116:77-83. 10.1016/j.talanta.2013.04.074.
41. Leffler A.M., Smith P.B., de Armas A., Dorman F.L. The analytical investigation of synthetic street drugs containing cathinone analogs. Forensic Sci. Int. 2014, 234:50-56. 10.1016/j.forsciint.2013.08.021.
42. Kanu A.B., Brandt S.D., Williams M.D., Zhang N., Hill H.H. Analysis of psychoactive cathinones and tryptamines by electrospray ionization atmospheric pressure ion mobility time-of-flight mass spectrometry. Anal. Chem. 2013, 85(18):8535-8542. 10.1021/ac401951a.