Cross-reactivity of designer drugs, including cathinone derivatives, in commercial enzyme-linked immunosorbent assays

Drug Testing and Analysis

Volumn 6, Issue 7-8, 2014, Pages 716-727

  Swortwood, Madeleine J ^a   Hearn, W Lee ^b   Decaprio, Anthony P ^a  

^a FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^b Miami Dade Medical Examiner Department   (United States)

Author keywords

Bath salts; Cathinone derivatives; Cross reactivity; Designer drugs; Immunoassay

Indexed keywords

AMINES; DRUG PRODUCTS;

BATH SALT; CATHINONE; CATHINONE DERIVATIVE; COMMERCIAL ENZYMES; CROSS-REACTIVITY; DESIGNER DRUGS; DRUG MARKETS; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOASSAY; PHENYLETHYLAMINES;

SALTS;

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMINE; AMPHETAMINE; CATHINONE; DESIGNER DRUG; METHAMPHETAMINE; N ETHYLAMPHETAMINE; PHENETHYLAMINE; PIPERAZINE DERIVATIVE; REAGENT; TRYPTAMINE DERIVATIVE; ALKALOID; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CROSS REACTIVITY; DRUG DETERMINATION; DRUG STRUCTURE; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PRIORITY JOURNAL; SERUM; PROCEDURES; SUBSTANCE ABUSE;

ALKALOIDS; DESIGNER DRUGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INDICATORS AND REAGENTS; SUBSTANCE ABUSE DETECTION;

EID: 84904580989     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1489     Document Type: Article

References (40)

1. M. Coppola, R. Mondola . Synthetic cathinones: Chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as 'bath salts' or 'plant food'. Toxicol. Lett. 2012, 211, 144.
2. S. Elliott, C. Smith . Investigation of the first deaths in the United Kingdom involving the detection and quantitation of the piperazines BZP and 3-TFMPP. J. Anal. Toxicol. 2008, 32, 172.
3. K.J. Lusthof, R. Oosting, A. Maes, M. Verschraagen, A. Dijkhuizen, A.G.A. Sprong . A case of extreme agitation and death after the use of mephedrone in the Netherlands. Forensic Sci. Int. 2011, 206, e93.
4. J.M. McClean, A. Anspikian, J.W. Tsuang . Bath salt use: A case report and review of the literature. J. Dual Diagnosis 2012, 8, 250.
5. B.L. Murray, C.M. Murphy, M.C. Beuhler . Death following recreational use of designer drug 'bath salts' containing 3, 4-methylenedioxypyrovalerone (MDPV). J. Med. Toxicol. 2012, 8, 69.
6. E. Tanaka, T. Kamata, M. Katagi, H. Tsuchihashi, K. Honda . A fatal poisoning with 5-methoxy-N, N-diisopropyltryptamine, Foxy. Forensic Sci. Int. 2006, 163, 152.
7. H. Torrance, G. Cooper . The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in Scotland. Forensic Sci. Int. 2010, 202, e62.
8. M. Verschraagen, A. Maes, B. Ruiter, I.J. Bosman, B.E. Smink, K.J. Lusthof . Post-mortem cases involving amphetamine-based drugs in the Netherlands - Comparison with driving under the influence cases. Forensic Sci. Int. 2007, 170, 163.
9. M. Wikstrom, G. Thelander, I. Nystrom, R. Kronstrand . Two fatal intoxications with the new designer drug methedrone (4-methoxymethcathinone). J. Anal. Toxicol. 2010, 34, 594.
10. S. Zwingenberger, J. Pietsch, A. Hommola, J. Drebler . Illegal drug-related deaths in East Germany between 1995 and 2004. Forensic Sci. Int. 2010, 199, 58.
11. B.J. Warrick, J. Wilson, M. Hedge, S. Freeman, K. Leonard, C. Aaron . Lethal serotonin syndrome after methylone and butylone ingestion. J. Med. Toxicol. 2012, 8, 65.
12. M.V. Stoica, A.R. Felthous . Acute psychosis induced by bath salts: A case report with clinical and forensic implications. J. Forensic Sci. 2013, 58, 530.
13. J.M. McClean, A. Anspikian, J.W. Tsuang . Bath salt use: A case report and review of the literature. J. Dual Diagnosis 2012, 8, 250.
14. H. Regunath, V.K. Ariyamuthu, P. Dalal, M. Misra . Bath salt intoxication causing acute kidney injury requiring hemodialysis. Hemodial. Int. 2012, 16, S47.
15. S. Rojek, M. Klys, M. Strona, M. Maciow, K. Kula . 'Legal highs' - Toxicity in the clinical and medico-legal aspect as exemplified by suicide with bk-MBDB administration. Forensic Sci. Int. 2012, 222, e1.
16. D. Zuba, P. Adamowicz, B. Byrska . Detection of buphedrone in biological and non-biological material - Two case reports. Forensic Sci. Int. 2012, 227, 15.
17. N. Sadeg, A. Darie, B. Vilamot, M. Passamar, B. Frances, H. Belhadj-Tahar . Case report of cathinone-like designer drug intoxication psychosis and addiction with serum identification. Addict. Disord. Treat. 2013. DOI: 10.1097/ADT.0b013e318285308d.
18. Y.P. Gaillard, A. Cuquel, A. Boucher, L. Romeuf, F. Bevalot, J. Prevosto, J. Menard . A fatality following ingestion of the designer drug meta-chlorophenylpiperazine (mCPP) in an asthmatic - HPLC-MS/MS detection in biofluids and hair. J. Forensic Sci. 2013, 58, 263.
19. A. Bosak, F. LoVecchio, M. Levine . Recurrent seizures and serotonin syndrome following '2C-I' ingestion. J. Med. Toxicol. 2013, DOI: 10.1007/s13181-013-0287-x.
20. S.L. Thornton, J. Lo, R.F. Clark, A.H.B. Wu, R.R. Gerona . Simultaneous detection of multiple designer drugs in serum, urine, and CSF in a patient with prolonged psychosis. Clin. Toxicol. 2012, 50, 1165.
21. A.S. Christophersen . Amphetamine designer drugs - an overview and epidemiology. Toxicol. Lett. 2000, 112, 127.
22. K.R. Allen, R. Azad, H.P. Field, D.K. Blake . Replacement of immunoassay by LC tandem mass spectrometry for the routine measurement of drugs of abuse in oral fluid. Ann. Clin. Biochem. 2005, 42, 277.
23. A. Wohlfarth, W. Weinmann . Bioanalysis of new designer drugs. Bioanalysis 2010, 2, 965.
24. M. Park, H. Choi, H. Son, M. Lim, H. Chung . Cross-reactivity of amphetamine analogues in various immunoassays. J. Pharm. Soc. Korea 2003, 47, 266.
25. C.R. Crooks, S. Brown . Roche DAT immunoassay: Sensitivity and specificity testing for amphetamines, cocaine, and opiates in oral fluid. J. Anal. Toxicol. 2010, 34, 103.
26. J.T. Cody, R. Schwarzhoff . Fluorescence polarization immunoassay detection of amphetamine, methamphetamine, and illicit amphetamine analogs. J. Anal. Toxicol. 1993, 17, 26.
27. L.G. Apollonio, I.R. Whittall, D.J. Pianca, J.M. Kyd, W.A. Maher . Matrix effect and cross-reactivity of select amphetamine-type substances, designer analogues, and putrefactive amines using the Bio-Quant Direct ELISA presumptive assays for amphetamine and methamphetamine. J. Anal. Toxicol. 2007, 31, 208.
28. S. Kerrigan, M.B. Mellon, S. Banuelos, C. Arndt . Evaluation of commercial enzyme-linked immunosorbent assays to identify psychedelic phenethylamines. J. Anal. Toxicol. 2011, 35, 444.
29. K. Nakanishi, A. Miki, K. Zaitsu, H. Kamata, N. Shima, T. Kamata, M. Katagi, M. Tatsuno, H. Tsuchihashi, K. Suzuki . Cross-reactivities of various phenethylamine-type designer drugs to immunoassays for amphetamines, with special attention to the evaluation of the one-step urine drug test Instant-View™, and the Emit® assays for use in drug enforcement. Forensic Sci. Int. 2012, 217, 174.
30. D. de Boer, I.J. Bosman, E. Hidvegi, C. Manzoni, A.A. Benko, L.J.A.L. dos Reys, R.A.A. Maes . Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market. Forensic Sci. Int. 2001, 121, 47.
31. S.P. Vorce, J.M. Holler, B. Levine, M.R. Past . Detection of 1-benzylpiperazine and 1-(3-trifluoromethylphenyl)-piperazine in urine analysis specimens using GC-MS and LC-ESI-MS. J. Anal. Toxicol. 2008, 32, 444.
32. B.K. Logan, A.G. Constantino, E.F. Rieders, D. Sanders . Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogenic trifluoromethylphenylpiperazine cross-react with the EMIT®II Ecstasy immunoassay in urine. J. Anal. Toxicol. 2010, 34, 587.
33. D.M. Boland, W. Andollo, G.W. Hime, W.L. Hearn . Fatality due to acute alpha-methyltryptamine intoxication. J. Anal. Toxicol. 2005, 29, 394.
34. S.J. Marin, C. Moore, G.A. McMillin . Cross-reactivity of phentermine with an immunoassay designed to detect amphetamine in a meconium specimen. Clin. Chem. 2009, 55, 589.
35. M. Balikova . Nonfatal and fatal DOB (2, 5-dimethoxy-4-bromoamphetamine) overdose. Forensic Sci. Int. 2005, 153, 85.
36. S.P. Vorce, J.H. Sklerov . A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS. J. Anal. Toxicol. 2004, 28, 407.
37. M. Miyajima, T. Matsumoto, S. Ito . 2C-T-4 intoxication: Acute psychosis caused by a designer drug. Psychiat. Clin. Neuros. 2008, 62, 243.
38. A.J. Dickson, S.P. Vorce, B. Levine, M.R. Past . Multiple-drug toxicity caused by coadministration of 4-methylmethcathinone (mephedrone) and heroin. J. Anal. Toxicol. 2010, 34, 162.
39. C. Bell, C. George, A.T. Kicman, A. Traynor . Development of a rapid LC-MS/MS method for direct urinalysis of designer drugs. Drug Test. Anal. 2011, 3, 496.
40. A.M. Macher, T.M. Penders . False-positive phencyclidine immunoassay results caused by 3, 4-methylenedioxypyrovalerone (MDPV). Drug Test. Anal. 2012, 5, 130.