Screening of seized emerging drugs by ultra-high performance liquid chromatography with photodiode array ultraviolet and mass spectrometric detection

Forensic Science International

Volumn 237, Issue , 2014, Pages 100-111

  Li, Li ^a   Lurie, Ira S ^b  

^a Drug Enforcement Administration   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

2C compounds; Cathinones; Emerging drugs; Phenethylamines; Synthetic cannabinoids cannabimimetics; UHPLC PDA UV MS

Indexed keywords

CANNABINOID; PHENETHYLAMINE DERIVATIVE; ALKALOID; CATHINONE; DESIGNER DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CHEMICAL STRUCTURE; IONIZATION; LIMIT OF DETECTION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROCESS DEVELOPMENT; RELIABILITY; SCREENING TEST; SEPARATION TECHNIQUE; SUBSTITUTION REACTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY PHOTODIODE ARRAY MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY ULTRAVIOLET MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; DRUG CONTAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROCEDURES; ULTRAVIOLET SPECTROPHOTOMETRY;

ALKALOIDS; CANNABINOIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESIGNER DRUGS; DRUG CONTAMINATION; MASS SPECTROMETRY; PHENETHYLAMINES; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84895759259     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2014.01.018     Document Type: Article

References (36)

1. Collins M. Some new psychoactive substances: precursor chemicals and synthesis-driven end-products. Drug Test. Anal. 2011, 3:404-416.
2. Coppola M., Mondola R. Synthetic cathinones: chemistry, pharmacology and toxicology of a new class of designer drugs marketed as "bath salts" or "plant food". Toxicol. Lett. 2012, 211:144-149.
3. Meyer M.R., Peters F.T. Analytical toxicology of emerging drugs of abuse-an update. Ther. Drug Monit. 2012, 34:615-621.
4. Vardakou I., Pistos C., Spiliopoulou C. Drugs for youth via Internet and the example of mephedrone. Toxicol. Lett. 2011, 201:191-195.
5. Hudson S., Ramsey J. The emergence and analysis of synthetic cannabinoids. Drug Test. Anal. 2011, 3:466-478.
6. Becker J., Neis P., Röhich J., Zörntlein S. A fatal para-methoxymethamphetamine intoxication. Leg. Med. 2003, 2:S138-S141.
7. Vardakou I., Pistos C., Dona A., Spiliopoulou C., Athanaselis S. Naphyrone: a legal high not legal any more. Drug Chem. Toxicol. 2012, 35:467-471.
8. Bossong M.G., Van Dijk J.P., Niesink R.J. Methylone and mCPP, two new drugs of abuse?. Addict. Biol. 2005, 10:321-323.
9. Glennon R.A., Yousif M., Naiman N., Kalix P. Methcathinone: a new and potent amphetamine-like agent. Pharmacol. Biochem. Behav. 1987, 26:547-551.
10. Establishment of drug codes for 26 substances. Fed. Regist. 2013, 78(3):664. Department of Justice, Drug Enforcement Administration.
11. Dresen S., Ferreirós N., Pütz M., Westphal F., Zimmermann R., Auwärter V. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J. Mass Spectrom. 2010, 45:1186-1194.
12. Zuba D., Sekuła K., Buczek A. 25C-NBOMe - new potent hallucinogenic substance identified on the drug market. Forensic Sci. Int. 2012, 227:7-14.
13. Camilleri A., Johnston M.R., Brennan M., Davis S., Caldicott D.G. Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone. Forensic Sci. Int. 2010, 197:59-66.
14. Reitzel L.A., Dalsgaard P.W., Müller I.B., Cornett C. Identification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish Internet company. Drug Test. Anal. 2012, 4:342-354.
15. Brandt S.D., Sumnall H.R., Measham F., Cole J. Analysis of second-generation 'legal highs' in the UK: initial findings. Drug Test. Anal. 2010, 2:377-382.
16. Ernst L., Krüger K., Lindigkeit R., Schiebel H.M., Beuerle T. Synthetic cannabinoids in "spice-like" herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market. Forensic Sci. Int. 2012, 222:216-222.
17. Uchiyama N., Kawamura M., Kikura-Hanajiri R., Goda Y. Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products. Forensic Toxicol. 2012, 30:114-125.
18. Uchiyama N., Kikura-Hanajiri R., Ogata J., Goda Y. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Sci. Int. 2010, 198:31-38.
19. Nakajima J., Takahashi M., Seto T., Kanai C., Suzuki J., Yoshida M., Hamano T. Identification and quantitation of two benzoylindoles AM-694 and (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone, and three cannabimimetic naphthoylindoles JWH-210, JWH-122, and JWH-019 as adulterants in illegal products obtained via the Internet. Forensic Toxicol. 2012, 29:95-110.
20. Jankovics P., Váradi A., Tölgyesi L., Lohner S., Németh-Palotás J., Balla J. Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary. Forensic Sci. Int. 2012, 214:27-32.
21. Takahashi M., Nagashima M., Suzuki J., Seto T., Yasuda I., Yoshida T. Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry. Talanta 2009, 77:1245-1272.
22. Valoti E., Casagni E., Dell'Acqua L., Pallavicini M., Roda G., Rusconi C., Straniero V., Gambaro V. Identification of 1-butyl-3(1-(4-methyl)naphthoyl)indole detected for the first time in herbal high products on the Italian market. Forensic Sci. Int. 2012, 223:42-46.
23. Tsujikawa K., Mikuma T., Kuwayama K., Miyaguchi H., Kanamoria T., Iwata Y.T., Inoue H. Degradation pathways of 4-methylmethcathinone in alkaline solution and stability of methcathinone analogs in various pH solutions. Forensic Sci. Int. 2012, 220:103-110.
24. Tsujikawa K., Mikuma T., Kuwayama K., Miyaguchi H., Kanamori T., Iwata Y., Inoue H. Identification and differentiation of methcathinone analogs by gas chromatography-mass spectrometry. Drug Test. Anal. 2013, 5:670-677.
25. Zuba D., Sekula K. Analytical characterization of three hallucinogenic N-(2-methoxy) benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Test. Anal. 2013, 5:634-645.
26. Zuba D., Sekuła K. Identification and characterization of 2,5-dimethoxy-3,4-dimethyl-B-phenethylamine (2C-G)-a new designer drug. Drug Test. Anal. 2013, 5:549-559.
27. Logan B.K., Reinhold L.E., Xu A., Diamond F.X. Identification of synthetic cannabinoids in herbal incense blends in the United States. J. Forensic Sci. 2012, 57:1168-1180.
28. Sekula K., Zuba D., Stanaszek R. Identification of naphthoylindoles acting on cannabinoid receptors based on their fragmentation patterns under ESI-QTOFMS. J. Mass Spectrom. 2012, 47:632-643.
29. Archer R.P. Fluoromethcathinone, a new substance of abuse. Forensic Sci. Int. 2009, 185:10-19.
30. McDermott S.D., Power J.D., Kavanagh P., O'Brien J. The analysis of substituted cathinones. Part 2: an investigation into the phenylacetone based isomers of 4-methylmethcathinone and N-ethylcathinone. Forensic Sci. Int. 2012, 212:13-21.
31. Rösner P., Quednow B., Girreser U., Junge T. Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substances analogues (designer drugs). Forensic Sci. Int. 2012, 148:143-156.
32. Abiedalla Y.F., Abdel-Hay K., DeRuiter J., Clark C.R. Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV). Forensic Sci. Int. 2012, 223:189-197.
33. Awad T., Clark C.R., DeRuiter J. Chromatographic and mass spectral studies of methoxymethcathinones related to 3,4-methylenedioxymethamphetamine. J. Chromatogr. Sci. 2006, 44:155-161.
34. Westphal F., Junge T. Ring positional differentiation of isomeric N-alkylated fluorocathinones by gas chromatography/tandem mass spectrometry. Forensic Sci. Int. 2012, 223:97-105.
35. Lurie I.S., Iio R. Use of multiple-reaction monitoring ratios for identifying incompletely resolved fentanyl homologs and analogs via ultra-high-pressure liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2009, 1216:1515-1519.
36. Pavia D., Lampman G.M., Kriz G.S. Introduction to Spectroscopy 2001, Harcourt College Publishers, Orlando, FL, (Chapter 7). third ed.