Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation

Journal of Medicinal Chemistry

Volumn 57, Issue 18, 2014, Pages 7702-7715

  Ferla, Salvatore ^a   Aboraia, Ahmed S ^a   Brancale, Andrea ^a   Pepper, Christopher J ^a   Zhu, Jinge ^b   Ochalek, Justin T ^b   Deluca, Hector F ^b   Simons, Claire ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (3,5 DIMETHOXYSTYRYL)PHENYL] 5 PHENYL 4,5 DIHYDROOXAZOLE; 2 [4 (4 FLUOROSTYRYL)PHENYL] 5 PHENYL 4,5 DIHYDROOXAZOLE; 2 [4 (4 METHOXYSTYRYL)PHENYL] 5 PHENYL 4,5 DIHYDROOXAZOLE; 4 [2 (4 FLUOROPHENYL)ETHYL] N (2 IMIDAZOL 1 YL 2 PHENYLETHYL)BENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYP24A1 PROTEIN; FLUDARABINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEME; IMIDAZOLE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; N (2 HYDROXY 2 PHENYLETHYL) 4 PHENYLSULFAMOYL BENZAMIDE; N (2 HYDROXY 2 PHENYLETHYL) 4 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZAMIDE; N (2 HYDROXY 2 PHENYLETHYL) 4 [2 (3,5 DIMETHOXYPHENYL)VINYL]BENZAMIDE; N (2 HYDROXY 2 PHENYLETHYL) 4 [2 (4 FLUOROPHENYL)VINYL]BENZAMIDE; N (2 HYDROXY 2 PHENYLETHYL) 4 [2 (4 METHOXYPHENYL)VINYL]BENZAMIDE; N METHANESULFONYL N PHENYL 4 (5 PHENYL 4,5 DIHYDROOXAZOL 2 YL)BENZENESULFONAMIDE; N [2 (1H IMIDAZOL 1 YL) 2 PHENYLETHYL] 4 (3,4,5 TRIMETHOXYSTYRYL)BENZAMIDE; N [2 (1H IMIDAZOL 1 YL) 2 PHENYLETHYL] 4 (3,5 DIMETHOXYSTYRYL)BENZAMIDE; N [2 (1H IMIDAZOL 1 YL) 2 PHENYLETHYL] 4 (4 FLUOROSTYRYL)BENZAMIDE; N [2 (1H IMIDAZOL 1 YL) 2 PHENYLETHYL] 4 PHENYLSULFONYL BENZAMIDE; N [2 (1H IMIDAZOL1 YL) 2 PHENYLETHYL] 4 (4 METHOXYSTYRYL)BENZAMIDE; OXYGENASE; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN D; COLECALCIFEROL 24 HYDROXYLASE; CYTOCHROME P450 INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; HYDROGEN BOND; LEUKEMIA CELL; MOLECULAR DOCKING; UPREGULATION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; IC50; METABOLISM; PATHOLOGY; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; CYTOCHROME P-450 ENZYME INHIBITORS; HEME; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MODELS, MOLECULAR; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D3 24-HYDROXYLASE;

EID: 84907463126     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5009314     Document Type: Article

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