메뉴 건너뛰기




Volumn 25, Issue 3, 2012, Pages 246-251

Vitamin D and multiple sclerosis: Epidemiology, immunology, and genetics

Author keywords

Epidemiology; Multiple sclerosis; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; BETA1A INTERFERON; ERGOCALCIFEROL; INTERLEUKIN 17; VITAMIN D; VITAMIN D RECEPTOR;

EID: 84860735624     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0b013e3283533a7e     Document Type: Review
Times cited : (83)

References (48)
  • 1
    • 0016209011 scopus 로고
    • Multiple sclerosis: Vitamin D and calcium as environmental determinants of prevalence (A viewpoint) Part 1: Sunlight, dietary factors and epidemiology
    • Goldberg P. Multiple sclerosis: vitamin D and calcium as environmental determinants of prevalence (A viewpoint) Part 1: Sunlight, dietary factors and epidemiology. Int J Environ Stud 1974; 6:19-27.
    • (1974) Int J Environ Stud , vol.6 , pp. 19-27
    • Goldberg, P.1
  • 2
    • 0028898668 scopus 로고
    • Environmental factors that influence the cutaneous production of vitamin D
    • Holick MF. Environmental factors that influence the cutaneous production of vitamin D. Am J Clin Nutr 1995; 61 (Suppl):638S-645S.
    • (1995) Am J Clin Nutr , vol.61 , Issue.SUPPL.
    • Holick, M.F.1
  • 4
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006; 296:2832-2838.
    • (2006) JAMA , vol.296 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3
  • 5
    • 79954652299 scopus 로고    scopus 로고
    • Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study
    • Banwell B, Bar-Or A, Arnold DL, et al. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neurol 2011; 10:436-445.
    • (2011) Lancet Neurol , vol.10 , pp. 436-445
    • Banwell, B.1    Bar-Or, A.2    Arnold, D.L.3
  • 6
    • 77950910418 scopus 로고    scopus 로고
    • UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production
    • Becklund BR, Severson KS, Vang SV, Deluca HF. UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proc Natl Acad Sci USA 2010; 107:6418-6423.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6418-6423
    • Becklund, B.R.1    Severson, K.S.2    Vang, S.V.3    Deluca, H.F.4
  • 7
    • 79951605437 scopus 로고    scopus 로고
    • Sun exposure and vitamin D are independent risk factors for CNS demyelination
    • Lucas RM, Ponsonby AL, Dear K, et al. Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology 2011; 76:540-548.
    • (2011) Neurology , vol.76 , pp. 540-548
    • Lucas, R.M.1    Ponsonby, A.L.2    Dear, K.3
  • 8
    • 82155203466 scopus 로고    scopus 로고
    • Sun exposure and vitamin D are independent risk factors for CNS demyelination
    • Ascherio A, Munger KL, Giovannucci E, et al. Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology 2011; 77:1405-1406.
    • (2011) Neurology , vol.77 , pp. 1405-1406
    • Ascherio, A.1    Munger, K.L.2    Giovannucci, E.3
  • 9
    • 77949424680 scopus 로고    scopus 로고
    • Environmental factors and their timing in adult-onset multiple sclerosis
    • Handel AE, Giovannoni G, Ebers GC, Ramagopalan SV. Environmental factors and their timing in adult-onset multiple sclerosis. Nat Rev Neurol 2010; 6:156-166.
    • (2010) Nat Rev Neurol , vol.6 , pp. 156-166
    • Handel, A.E.1    Giovannoni, G.2    Ebers, G.C.3    Ramagopalan, S.V.4
  • 10
    • 79958230860 scopus 로고    scopus 로고
    • Gestational vitamin D and the risk of multiple sclerosis in offspring
    • Mirzaei F, Michels KB, Munger K, et al. Gestational vitamin D and the risk of multiple sclerosis in offspring. Ann Neurol 2011; 70:30-40.
    • (2011) Ann Neurol , vol.70 , pp. 30-40
    • Mirzaei, F.1    Michels, K.B.2    Munger, K.3
  • 11
    • 79953792706 scopus 로고    scopus 로고
    • Dietary intake of vitamin D during adolescence and risk of multiple sclerosis
    • Munger KL, Chitnis T, Frazier AL, et al. Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. J Neurol 2011; 258:479-485.
    • (2011) J Neurol , vol.258 , pp. 479-485
    • Munger, K.L.1    Chitnis, T.2    Frazier, A.L.3
  • 12
    • 84862538949 scopus 로고    scopus 로고
    • Patterns of dietary and herbal supplement use by multiple sclerosis patients
    • doi:10.1007/s00415-011-6226-3. [Epub ahead of print]
    • O'Connor K, Weinstock-Guttman B, Carl E, et al. Patterns of dietary and herbal supplement use by multiple sclerosis patients. J Neurol 2011. doi:10.1007/s00415-011-6226-3. [Epub ahead of print]
    • (2011) J Neurol
    • O'Connor, K.1    Weinstock-Guttman, B.2    Carl, E.3
  • 13
    • 57449105480 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004
    • Looker AC, Pfeiffer CM, Lacher DA, et al. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008; 88:1519-1527.
    • (2008) Am J Clin Nutr , vol.88 , pp. 1519-1527
    • Looker, A.C.1    Pfeiffer, C.M.2    Lacher, D.A.3
  • 14
    • 79958124650 scopus 로고    scopus 로고
    • Vitamin D in African Americans with multiple sclerosis
    • Gelfand JM, Cree BA, McElroy J, et al. Vitamin D in African Americans with multiple sclerosis. Neurology 2011; 76:1824-1830.
    • (2011) Neurology , vol.76 , pp. 1824-1830
    • Gelfand, J.M.1    Cree, B.A.2    McElroy, J.3
  • 15
    • 78751580274 scopus 로고    scopus 로고
    • Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients
    • Weinstock-Guttman B, Zivadinov R, Qu J, et al. Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients. J Neurol Neurosurg Psychiatry 2011; 82:189-195.
    • (2011) J Neurol Neurosurg Psychiatry , vol.82 , pp. 189-195
    • Weinstock-Guttman, B.1    Zivadinov, R.2    Qu, J.3
  • 16
    • 77951713604 scopus 로고    scopus 로고
    • Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis
    • Mowry EM, Krupp LB, Milazzo M, et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol 2010; 67:618-624.
    • (2010) Ann Neurol , vol.67 , pp. 618-624
    • Mowry, E.M.1    Krupp, L.B.2    Milazzo, M.3
  • 17
    • 77955291052 scopus 로고    scopus 로고
    • Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis
    • Simpson S Jr, Taylor B, Blizzard L, et al. Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol 2010; 68:193-203.
    • (2010) Ann Neurol , vol.68 , pp. 193-203
    • Simpson Jr., S.1    Taylor, B.2    Blizzard, L.3
  • 18
    • 82955236170 scopus 로고    scopus 로고
    • A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis
    • Stein MS, Liu Y, Gray OM, et al. A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology 2011; 77:1611-1618.
    • (2011) Neurology , vol.77 , pp. 1611-1618
    • Stein, M.S.1    Liu, Y.2    Gray, O.M.3
  • 19
    • 82555176755 scopus 로고    scopus 로고
    • Prevention and treatment of MS: Studying the effects of vitamin D
    • Munger KL, Ascherio A. Prevention and treatment of MS: studying the effects of vitamin D. Mult Scler 2011; 17:1405-1411.
    • (2011) Mult Scler , vol.17 , pp. 1405-1411
    • Munger, K.L.1    Ascherio, A.2
  • 20
    • 81255152070 scopus 로고    scopus 로고
    • Efficacy of vitamin D(3) as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: A phase II, multicenter, double-blind, randomized, placebo-controlled trial
    • Smolders J, Hupperts R, Barkhof F, et al. Efficacy of vitamin D(3) as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: a phase II, multicenter, double-blind, randomized, placebo-controlled trial. J Neurol Sci 2011; 311:44-49.
    • (2011) J Neurol Sci , vol.311 , pp. 44-49
    • Smolders, J.1    Hupperts, R.2    Barkhof, F.3
  • 21
    • 4143140820 scopus 로고    scopus 로고
    • Genetics and biology of vitamin D receptor polymorphisms
    • Uitterlinden AG, Fang Y, Van Meurs JB, et al. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004; 338:143-156.
    • (2004) Gene , vol.338 , pp. 143-156
    • Uitterlinden, A.G.1    Fang, Y.2    Van Meurs, J.B.3
  • 22
    • 84855584954 scopus 로고    scopus 로고
    • Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: A meta-analysis of case-control studies
    • Huang J, Xie ZF. Polymorphisms in the vitamin D receptor gene and multiple sclerosis risk: A meta-analysis of case-control studies. J Neurol Sci 2012; 313:79-85.
    • (2012) J Neurol Sci , vol.313 , pp. 79-85
    • Huang, J.1    Xie, Z.F.2
  • 23
    • 84855930078 scopus 로고    scopus 로고
    • Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis
    • Cox MB, Ban M, Bowden NA, et al. Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis. Mult Scler 2012; 18:16-22.
    • (2012) Mult Scler , vol.18 , pp. 16-22
    • Cox, M.B.1    Ban, M.2    Bowden, N.A.3
  • 24
    • 84255194782 scopus 로고    scopus 로고
    • Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci
    • Patsopoulos NA, de Bakker PI. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 2011; 70:897-912.
    • (2011) Ann Neurol , vol.70 , pp. 897-912
    • Patsopoulos, N.A.1    De Bakker, P.I.2
  • 25
    • 77955052903 scopus 로고    scopus 로고
    • Common genetic determinants of vitamin D insufficiency: A genome-wide association study
    • Wang TJ, Zhang F, Richards JB, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010; 376:180-188.
    • (2010) Lancet , vol.376 , pp. 180-188
    • Wang, T.J.1    Zhang, F.2    Richards, J.B.3
  • 26
    • 77952313673 scopus 로고    scopus 로고
    • Genome-wide association study of circulating vitamin D levels
    • Ahn J, Stolzenberg-Solomon R, Simon K, et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 2010; 19:2739-2745.
    • (2010) Hum Mol Genet , vol.19 , pp. 2739-2745
    • Ahn, J.1    Stolzenberg-Solomon, R.2    Simon, K.3
  • 27
    • 79955680247 scopus 로고    scopus 로고
    • Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians
    • Orton SM, Ramagopalan SV, Para AE, et al. Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians. J Neurol Sci 2011; 305:116-120.
    • (2011) J Neurol Sci , vol.305 , pp. 116-120
    • Orton, S.M.1    Ramagopalan, S.V.2    Para, A.E.3
  • 28
    • 80054725615 scopus 로고    scopus 로고
    • Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Simon KC, Munger KL, Kraft P, et al. Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis. J Neurol 2011; 258:1676-1682.
    • (2011) J Neurol , vol.258 , pp. 1676-1682
    • Simon, K.C.1    Munger, K.L.2    Kraft, P.3
  • 29
    • 84859926176 scopus 로고    scopus 로고
    • ANKRD55 and DHCR7 are novel multiple sclerosis risk loci
    • doi:10.1038/gene.2011.81. [Epub ahead of print]
    • Alloza I, Otaegui D, de Lapuente AL, et al. ANKRD55 and DHCR7 are novel multiple sclerosis risk loci. Genes Immun 2011. doi:10.1038/gene.2011.81. [Epub ahead of print]
    • (2011) Genes Immun
    • Alloza, I.1    Otaegui, D.2    De Lapuente, A.L.3
  • 30
    • 79958822945 scopus 로고    scopus 로고
    • Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    • Cooper JD, Smyth DJ, Walker NM, et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes 2011; 60:1624-1631.
    • (2011) Diabetes , vol.60 , pp. 1624-1631
    • Cooper, J.D.1    Smyth, D.J.2    Walker, N.M.3
  • 31
    • 84255175933 scopus 로고    scopus 로고
    • Rare variants in the CYP27B1 gene are associated with multiple sclerosis
    • Ramagopalan SV, Dyment DA, Cader MZ, et al. Rare variants in the CYP27B1 gene are associated with multiple sclerosis. Ann Neurol 2011; 70:881-886.
    • (2011) Ann Neurol , vol.70 , pp. 881-886
    • Ramagopalan, S.V.1    Dyment, D.A.2    Cader, M.Z.3
  • 32
    • 80051535245 scopus 로고    scopus 로고
    • Current and past Epstein-Barr virus infection in risk of initial CNS demyelination
    • Lucas RM, Ponsonby AL, Dear K, et al. Current and past Epstein-Barr virus infection in risk of initial CNS demyelination. Neurology 2011; 77:371-379.
    • (2011) Neurology , vol.77 , pp. 371-379
    • Lucas, R.M.1    Ponsonby, A.L.2    Dear, K.3
  • 33
    • 80053608697 scopus 로고    scopus 로고
    • Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: A prospective study among United States military personnel
    • Munger KL, Levin LI, O'Reilly EJ, et al. Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel. Mult Scler 2011; 17:1185-1193.
    • (2011) Mult Scler , vol.17 , pp. 1185-1193
    • Munger, K.L.1    Levin, L.I.2    O'Reilly, E.J.3
  • 34
    • 79951782445 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
    • Mayne CG, Spanier JA, Relland LM, et al. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol 2011; 41:822-832.
    • (2011) Eur J Immunol , vol.41 , pp. 822-832
    • Mayne, C.G.1    Spanier, J.A.2    Relland, L.M.3
  • 35
    • 0036919768 scopus 로고    scopus 로고
    • The vitamin D receptor is necessary for 1alpha 25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice
    • Meehan TF, DeLuca HF. The vitamin D receptor is necessary for 1alpha, 25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice. Arch Biochem Biophys 2002; 408:200-204.
    • (2002) Arch Biochem Biophys , vol.408 , pp. 200-204
    • Meehan, T.F.1    Deluca, H.F.2
  • 36
    • 84855836920 scopus 로고    scopus 로고
    • A nonsecosteroidal vitamin D receptor modulator ameliorates experimental autoimmune encephalomyelitis without causing hypercalcemia
    • doi:10.4061/2011/132958. [Epub ahead of print]
    • Na S, Ma Y, Zhao J, et al. A nonsecosteroidal vitamin D receptor modulator ameliorates experimental autoimmune encephalomyelitis without causing hypercalcemia. Autoimmune Dis 2011; 2011. doi:10.4061/2011/132958. [Epub ahead of print]
    • (2011) Autoimmune Dis 2011
    • Na, S.1    Ma, Y.2    Zhao, J.3
  • 37
    • 79956287488 scopus 로고    scopus 로고
    • Predominance of Th2 polarization by vitaminDthrough aSTAT6- dependentmechanism
    • Sloka S, Silva C, Wang J, Yong VW. Predominance of Th2 polarization by vitaminDthrough aSTAT6-dependentmechanism. JNeuroinflamm2011; 8:56.
    • (2011) Jneuroinflamm , vol.8 , pp. 56
    • Sloka, S.1    Silva, C.2    Wang, J.3    Yong, V.W.4
  • 38
    • 24744443699 scopus 로고    scopus 로고
    • Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice
    • Spach KM, Hayes CE. Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice. J Immunol 2005; 175:4119-4126.
    • (2005) J Immunol , vol.175 , pp. 4119-4126
    • Spach, K.M.1    Hayes, C.E.2
  • 39
    • 80051798820 scopus 로고    scopus 로고
    • Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis
    • Deluca HF, Plum LA. Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis. Arch Biochem Biophys 2011; 513:140-143.
    • (2011) Arch Biochem Biophys , vol.513 , pp. 140-143
    • Deluca, H.F.1    Plum, L.A.2
  • 40
    • 78650790685 scopus 로고    scopus 로고
    • Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    • Smolders J, Peelen E, Thewissen M, et al. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One 2010; 5:e15235.
    • (2010) PLoS One , vol.5
    • Smolders, J.1    Peelen, E.2    Thewissen, M.3
  • 41
    • 80052528871 scopus 로고    scopus 로고
    • Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis
    • Kimball S, Vieth R, Dosch HM, et al. Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis. J Clin Endocrinol Metab 2011; 96:2826-2834.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2826-2834
    • Kimball, S.1    Vieth, R.2    Dosch, H.M.3
  • 42
    • 34247590137 scopus 로고    scopus 로고
    • Environmental risk factors for multiple sclerosis Part I: The role of infection
    • Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis. Part I: The role of infection. Ann Neurol 2007; 61:288-299.
    • (2007) Ann Neurol , vol.61 , pp. 288-299
    • Ascherio, A.1    Munger, K.L.2
  • 43
    • 36448929119 scopus 로고    scopus 로고
    • Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis
    • Holmoy T. Vitamin D status modulates the immune response to Epstein Barr virus: synergistic effect of risk factors in multiple sclerosis. Med Hypotheses 2007; 70:66-69.
    • (2007) Med Hypotheses , vol.70 , pp. 66-69
    • Holmoy, T.1
  • 44
    • 43949135788 scopus 로고    scopus 로고
    • A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10
    • Hayes CE, Donald Acheson E. A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10. Med Hypotheses 2008; 71:85-90.
    • (2008) Med Hypotheses , vol.71 , pp. 85-90
    • Hayes, C.E.1    Donald Acheson, E.2
  • 45
    • 79953324326 scopus 로고    scopus 로고
    • Vitamin D has a direct immunomodulatory effect on CD8 + T cells of patients with early multiple sclerosis and healthy control subjects
    • Lysandropoulos AP, Jaquiery E, Jilek S, et al. Vitamin D has a direct immunomodulatory effect on CD8 + T cells of patients with early multiple sclerosis and healthy control subjects. J Neuroimmunol 2011; 233:240-244.
    • (2011) J Neuroimmunol , vol.233 , pp. 240-244
    • Lysandropoulos, A.P.1    Jaquiery, E.2    Jilek, S.3
  • 46
    • 83555179164 scopus 로고    scopus 로고
    • Vitamin D sensitive EBNA-1 specific T cells in the cerebrospinal fluid of patients with multiple sclerosis
    • Lossius A, Vartdal F, Holmoy T. Vitamin D sensitive EBNA-1 specific T cells in the cerebrospinal fluid of patients with multiple sclerosis. J Neuroimmunol 2011; 240-241:87-96.
    • (2011) J Neuroimmunol , vol.240-241 , pp. 87-96
    • Lossius, A.1    Vartdal, F.2    Holmoy, T.3
  • 47
    • 66549129834 scopus 로고    scopus 로고
    • Immunomodulatory effects of Vitamin D in multiple sclerosis
    • Correale J, Ysrraelit MC, Gaitan MI. Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain 2009; 132:1146-1160.
    • (2009) Brain , vol.132 , pp. 1146-1160
    • Correale, J.1    Ysrraelit, M.C.2    Gaitan, M.I.3
  • 48
    • 0024516871 scopus 로고
    • 1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes
    • Provvedini DM, Manolagas SC. 1 Alpha,25-dihydroxyvitamin D3 receptor distribution and effects in subpopulations of normal human T lymphocytes. J Clin Endocrinol Metab 1989; 68:774-779.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 774-779
    • Provvedini, D.M.1    Manolagas, S.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.