Homology model of 1α,25-dihydroxyvitamin D3 24-hydroxylase cytochrome P450 24A1 (CYP24A1): Active site architecture and ligand binding

Journal of Steroid Biochemistry and Molecular Biology

Volumn 104, Issue 1-2, 2007, Pages 53-60

  Gomaa, Mohamed Sayed ^a   Simons, Claire ^a   Brancale, Andrea ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

1,25 Dihydroxyvitamin D3; CYP24; Docking studies; Homology model; Inhibitor interactions; MOE

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 24A1; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; N (2 (1H IMIDAZOL 1 YL) 2 PHENYLETHYL) 4' CHLOROBIPHENYL 4 CARBOXAMIDE; UNCLASSIFIED DRUG; CALCITRIOL; CYP2C8 PROTEIN, HUMAN; CYP2C9 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; LIGAND; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE; VITAMIN D 24 HYDROXYLASE; VITAMIN D 24-HYDROXYLASE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; LIGAND BINDING; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CALCITRIOL; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STEROID HYDROXYLASES;

EID: 33947157164     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.09.041     Document Type: Article

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