Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Yamasaki, Takeshi ^a   Suzuki, Akio ^a   Hasebe, Rie ^a   Horiuchi, Motohiro ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; CHLORPROMAZINE; MONOCLONAL ANTIBODY 44B1; PENTOSAN POLYSULFATE; PRION PROTEIN; PRION PROTEIN ANTIBODY; UNCLASSIFIED DRUG; 3-BETA-(2-(DIETHYLAMINO)ETHOXY)ANDROST-5-EN-17-ONE; ANDROSTANE DERIVATIVE; MONOCLONAL ANTIBODY; PRION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; IMMUNOFLUORESCENCE TEST; LYSOSOME; MIGRATION INHIBITION; MOLECULAR DYNAMICS; MOUSE; NEUROBLASTOMA CELL LINE; NONHUMAN; PRION DISEASE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL FRACTIONATION; COMPARATIVE STUDY; DRUG EFFECTS; ENDOSOME; IMMUNOLOGY; METABOLISM; PRION; PRION DISEASES; PROTEIN TRANSPORT; TUMOR CELL LINE;

ANDROSTENES; ANIMALS; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CELL LINE, TUMOR; CHLORPROMAZINE; ENDOSOMES; LYSOSOMES; MICE; PENTOSAN SULFURIC POLYESTER; PRION DISEASES; PRIONS; PROTEIN TRANSPORT; PROTEOLYSIS; PRPC PROTEINS; PRPSC PROTEINS; SUBCELLULAR FRACTIONS;

EID: 84907452151     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0106516     Document Type: Article

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