Inhibition of PrPSc formation by synthetic O-sulfated glycopyranosides and their polymers

Biochemical and Biophysical Research Communications

Volumn 349, Issue 2, 2006, Pages 485-491

  Yamaguchi, Satoko ^a   Nishida, Yoshihiro ^b   Sasaki, Kenji ^b   Kambara, Mikie ^b   Kim, Chan Lan ^d   Ishiguro, Naotaka ^a   Nagatsuka, Takehiro ^c   Uzawa, Hirotaka ^c   Horiuchi, Motohiro ^d  

^a OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Glycosaminoglycan; Prion; Sulfated glycosides; Transmissible spongiform encephalopathy

Indexed keywords

4 SULFO N ACETYLGLUCOSAMINE; 6 SULFO N ACETYLGLUCOSAMINE; DEXTRAN SULFATE; GLYCOPYRANOSIDE; GLYCOPYRANOSIDE DERIVATIVE; GLYCOSAMINOGLYCAN POLYSULFATE; HEPARAN SULFATE; HEPARIN; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE DERIVATIVE; POLYMER; PRION PROTEIN; UNCLASSIFIED DRUG; CARBOHYDRATE; SULFUR;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SULFATION; ANIMAL; CELL PROLIFERATION; CHEMICAL MODEL; CHEMISTRY; METABOLISM; PRION; TUMOR CELL LINE;

ANIMALIA;

ACETYLGLUCOSAMINE; ANIMALS; CARBOHYDRATES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MODELS, CHEMICAL; POLYMERS; PRION DISEASES; PRIONS; PRPSC PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR;

EID: 33748423208     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.072     Document Type: Article

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