ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

Mitochondrion

Volumn 17, Issue , 2014, Pages 132-140

  Wang, Kent Z Q ^a   Zhu, Jianhui ^a   Dagda, Ruben K ^a,c   Uechi, Guy ^b   Cherra, Salvatore J ^a,d   Gusdon, Aaron M ^a,e   Balasubramani, Manimalha ^b   Chu, Charleen T ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

MAP kinases; Mitochondrial biogenesis; MtDNA; Parkinson disease; Phosphorylation

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; DNA BINDING PROTEIN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TFAM PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA CONTENT; DNA TRANSCRIPTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETIC TRANSFECTION; HEK293 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TRANSCRIPTION; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; PHOSPHORYLATION;

DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; MASS SPECTROMETRY; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84907439897     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2014.04.008     Document Type: Article

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