Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability

European Journal of Pharmaceutical Sciences

Volumn 63, Issue , 2014, Pages 178-186

  Stappaerts, Jef ^a   Wuyts, Benjamin ^a   Tack, Jan ^b   Annaert, Pieter ^a   Augustijns, Patrick ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Food effect; In situ intestinal perfusion; Permeability; Solubility; Blockers

Indexed keywords

ATENOLOL; BILE SALT; CARVEDILOL; METOPROLOL; MULTIDRUG RESISTANCE PROTEIN; PROPRANOLOL; TAUROCHOLIC ACID; CARBAZOLE DERIVATIVE; PROPANOLAMINE DERIVATIVE; SOLVENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DIALYSIS; DIALYSIS MEMBRANE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG PENETRATION; DRUG SOLUBILITY; FOOD; FOOD PROCESSING; HUMAN; HUMAN EXPERIMENT; INTESTINAL PERMEABILITY; INTESTINAL SOLUBILITY; INTESTINE ABSORPTION; INTESTINE FLUID; INTESTINE PERFUSION; LIPID DEGRADATION; LIPOPHILICITY; MALE; MICELLE; MICROCLIMATE; NONHUMAN; NORMAL HUMAN; PH; POSTPRANDIAL STATE; PRIORITY JOURNAL; RAT; SMALL INTESTINE; SOLUBILITY; STUDY; ANIMAL; BODY FLUID; CHEMISTRY; INTESTINAL SECRETIONS; METABOLISM; PERMEABILITY; SPRAGUE DAWLEY RAT;

ANIMALS; ATENOLOL; BODY FLUIDS; CARBAZOLES; HUMANS; INTESTINAL SECRETIONS; MALE; METOPROLOL; PERMEABILITY; PROPANOLAMINES; PROPRANOLOL; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS;

EID: 84907331060     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.07.009     Document Type: Article

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